Could a diabetes drug curb alcohol cravings? new trial investigates

NCT ID NCT06817356

Completed Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 17, 2026 · Updated 4 times

Summary

This phase 2 trial tests whether mazdutide, a drug given as a shot, can help people with alcohol use disorder drink less. About 308 participants will receive either mazdutide or a placebo for up to 36 weeks. The study measures changes in drinking behaviors using a standard questionnaire.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mazdutide (a drug given as a shot)
What this could lead to: If it works, this could point toward a new medication to help people with alcohol use disorder drink less.
What could go wrong: This is an early proof-of-concept study, so it may not show a clear benefit. The drug might also have side effects or not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alcohol abuse

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALCOHOL USE DISORDER

Contacts and locations

Locations

Adams Clinical

Watertown, Massachusetts, 02472, United States
Ark Clinical Research - Fountain Valley

Fountain Valley, California, 92708, United States
CenExel iResearch, LLC (CenExel iRA)

Decatur, Georgia, 30030, United States
Clinical Neuroscience Solutions Inc

Orlando, Florida, 32801, United States
Clinical Neuroscience Solutions Inc

Memphis, Tennessee, 38119, United States
Clinical Neuroscience Solutions, Inc.

Orlando, Florida, 32801, United States
Dallas Clinical Research Center/Pillar Research

Richardson, Texas, 75080, United States
Davis Clinical

The Bronx, New York, 10461, United States
DelRicht Research

Mandeville, Louisiana, 70471, United States
FutureSearch Trials of Dallas

Dallas, Texas, 75251, United States
Headlands Research - Scottsdale

Scottsdale, Arizona, 85260, United States
Headlands Research-Artemis San Diego

San Diego, California, 92123, United States
Ichor Research

Syracuse, New York, 13210, United States
K2 Medical Research

Maitland, Florida, 32751, United States
K2 Medical Research - Maitland

Maitland, Florida, 32751, United States
K2 Medical Research - Tampa

Tampa, Florida, 33634, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Redbird Research LLC

Las Vegas, Nevada, 89119, United States
Research Centers of America ( Hollywood )

Hollywood, Florida, 33024, United States
Rhode Island Mood & Memory Research Institute

East Providence, Rhode Island, 02914, United States
Richmond Behavioral Associates

Staten Island, New York, 10314, United States
Summit Headlands

Portland, Oregon, 97210, United States
Synergy San Diego

Lemon Grove, California, 91945, United States
Vitalix Clinical

Worcester, Massachusetts, 01608, United States
Woodland Resarch Northwest/ERG

Rogers, Arkansas, 72758, United States

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