New pill shows promise for regrowing hair in severe alopecia

NCT ID NCT03899259

Completed Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested the drug baricitinib in 606 adults with severe or very severe alopecia areata, a condition causing significant hair loss. Participants took either baricitinib or a placebo pill daily for up to 36 weeks. The main goal was to see if baricitinib could regrow enough scalp hair to reach a SALT score of 20 or less (meaning 80% or more hair coverage). Results showed that baricitinib helped many people regrow hair compared to placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Baricitinib (a pill that targets inflammation)
What this could lead to: If successful, this could offer a new treatment option for people with severe alopecia areata, helping regrow scalp hair.
What could go wrong: This is a completed Phase 3 trial, but baricitinib may not work for everyone and has potential side effects like infections or blood clots. Long-term safety data are still limited.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alopecia areata

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALOPECIA AREATA

Contacts and locations

Locations

Affiliated Hospital of Jiangsu University

Zhenjiang, Jiangsu, 212000, China
Ajou University Hospital

Suwon, Gyeonggi-do, 16499, South Korea
Associated Skin Care Specialists

New Brighton, Minnesota, 55112, United States
Beijing Chao-Yang Hospital, Capital Medical University

Beijing, Beijing Municipality, 100020, China
Beijing Friendship Hospital Affiliate of Capital University

Beijing, Beijing Municipality, 100050, China
Bexley Dermatology Research

Bexley, Ohio, 43209, United States
Boramae Medical Center

Dongjak-gu, Seoul-teukbyeolsi [Seoul], 07061, South Korea
Buenos Aires Skin

Buenos Aires, Buenos Aires F.D., 1055, Argentina
Center For Dermatology Clinical Research, Inc.

Fremont, California, 94538, United States
Centro de Investigaciones Metabólicas (CINME)

Ciudad Autónoma de Buenos Aires, Buenos Aires, 1027, Argentina
Centro de Investigaciones Médicas Tucuman

SAN M. de Tucuman, Tucumán Province, T4000AXL, Argentina
Centro de Pesquisa Sao Lucas

Campinas, São Paulo, 13034-685, Brazil
Chang Gung Medical Foundation-Linkou Branch

Taoyuan, 333, Taiwan
Chinese PLA General Hospital

Beijing, Beijing Municipality, 100853, China
Chung Shan Medical University Hospital

Taichung, Taichung, 402, Taiwan
Clinical Research Institute of Michigan, LLC

Chesterfield, Michigan, 48047, United States
Clinical Research Puerto Rico

San Juan, 00909, Puerto Rico
Clinical Trials SA Pty Ltd

Campbelltown, South Australia, 5073, Australia
Dankook University Hospital

Cheonan, Chungcheongnam-do, 31116, South Korea
Dawes Fretzin Clinical Research Group, LLC

Indianapolis, Indiana, 46250, United States
Dermatologists of Southwest Ohio

Mason, Ohio, 45040, United States
Dermatology Specialists of Charlotte

Charlotte, North Carolina, 28211, United States
Dermatology and Skin Cancer Specialists

Rockville, Maryland, 20850, United States
Emek Medical Center

Afula, Northern District, 1834111, Israel
Faculdade de Medicina do ABC

Santo André, São Paulo, 09060-870, Brazil
First Affiliated Hospital of Shanxi Medical University

Taiyuan, Shanxi, 30001, China
Florida Academic Centers Research and Education, LLC

Coral Gables, Florida, 33134, United States
ForCare Clinical Research

Tampa, Florida, 33613-1244, United States
Fremantle Dermatology

Fremantle, Western Australia, 6160, Australia
Fundacion Respirar

Buenos Aires, Ciudad Autonoma Buenos Aires, C1426ABO, Argentina
Great Lakes Research Group, Inc.

Bay City, Michigan, 48706, United States
Guangdong Province Dermatology Hospital

Guangzhou, Guangdong, 510018, China
Hadassah Medical Center

Jerusalem, Jerusalem, 9112001, Israel
Hamamatsu University Hospital

Hamamatsu, Shizuoka, 431-3192, Japan
Hamzavi Dermatology

Fort Gratiot, Michigan, 48059, United States
Hospital de Clínicas Da Universidade Estadual de Campinas

Campinas, São Paulo, 13083-888, Brazil
HuaShan Hospital Affiliated To Fudan University

Shanghai, Shanghai Municipality, 200040, China
IBPClin - Instituto Brasil de Pesquisa Clínica

Rio de Janeiro, 22241-180, Brazil
IDERJ - Instituto de Dermatologia e Estética do Brasil

Rio de Janeiro, Rio de Janeiro, 22470-220, Brazil
IPITEC

São Paulo, 01223-001, Brazil
Instituto de Neumonología y Dermatología

Capital Federal, Buenos Aires, 1425, Argentina
Investigate MD

Scottsdale, Arizona, 85255, United States
Irmandade da Santa Casa de Misericordia de Porto Alegre

Porto Alegre, Rio Grande do Sul, 90050-170, Brazil
Jiangsu Province Hospital

Nanjing, Jiangsu, 210029, China
Joseph J. Schwartz, M.D.

Troy, New York, 12180, United States
Juntendo Tokyo Koto Geriatric Medical Center

Koto-ku, Tokyo, 136-0075, Japan
Juntendo University Hospital

Bunkyo-ku, Tokyo, 113-8431, Japan
Kaiser Permanente Hospital

San Francisco, California, 94118, United States
Kyorin University Hospital

Mitaka, Tokyo, 181-8611, Japan
Kyunghee University Hospital at Gangdong

Seoul, Seoul-teukbyeolsi [Seoul], 134-090, South Korea
M3-Emerging Medical Research

Raleigh, North Carolina, 27612, United States
MediSearch Clinical Trials

Saint Joseph, Missouri, 64506, United States
National Cheng Kung University Hospital

Tainan, 704, Taiwan
National Taiwan University Hospital

Taipei, 10002, Taiwan
New England Research Associates

Bridgeport, Connecticut, 06606, United States
New Horizon Research Center

Miami, Florida, 33165, United States
Northwest Dermatology Institute

Portland, Oregon, 97210, United States
Oregon Dermatology and Research Center

Portland, Oregon, 97210, United States
Osaka City University Hospital

Osaka, 545-8586, Japan
Parra Dermatología

Mendoza, 5500, Argentina
Peking University Third Hospital

Beijing, Beijing Municipality, 100191, China
Progressive Clinical Research

San Antonio, Texas, 78213, United States
Qualmedica Research, LLC

Owensboro, Kentucky, 42303, United States
Quest Dermatology Research

Northridge, California, 91324, United States
Rabin Medical Center

Petah Tikva, Central District, 4941492, Israel
Rambam Medical Center

Haifa, Northern District, 3109601, Israel
Servidor Público Estadual - IAMSPE - centro de estudos urológicos

São Paulo, 04039-901, Brazil
Severance Hospital, Yonsei University Health System

Seoul, 03722, South Korea
Shanghai Skin Disease Hospital

Shanghai, Shanghai Municipality, 200071, China
Sheba Medical Center

Ramat Gan, Central District, 5262100, Israel
Sinclair Dermatology

Melbourne, Victoria, 3002, Australia
Skin & Cancer Foundation Australia

Westmead, New South Wales, 2045, Australia
Skin Health Institute Inc.

Carlton, Victoria, 3053, Australia
Soonchunhyang University Bucheon Hospital

Bucheon-si, Gyeonggi-do, 14584, South Korea
Soroka Medical Center

Beersheba, Southern District, 8410101, Israel
Sourasky Medical Center

Tel Aviv, Tell Abīb, 6423906, Israel
Stat Research

CABA, Buenos Aires, C1023AAB, Argentina
Suzanne Bruce and Associates, PA

Houston, Texas, 77056, United States
The Second Affiliated Hospital of Xi'an Jiaotong University

Xi'an, Shaanxi, 710004, China
The Second Affiliated Hospital of Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310052, China
The South Bend Clinic Center for Research

South Bend, Indiana, 46617, United States
The University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27516, United States
Tianjin Medical University General Hospital

Tianjin, Tianjin Municipality, 300052, China
Tokyo Medical Univ. Hospital

Shinjuku-ku, Tokyo, 160-0023, Japan
Total Skin and Beauty Dermatology Center, PC

Birmingham, Alabama, 35205, United States
Tufts Medical Center

Boston, Massachusetts, 02111, United States
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
Velocity Clinical Research, Providence

East Greenwich, Rhode Island, 02818, United States
Veracity Clinical Research Pty Ltd

Woolloongabba, Queensland, 4102, Australia
Virginia Clinical Research, Inc.

Norfolk, Virginia, 23502, United States
Vital Prospects Clinical Research Institute, P.C.

Tulsa, Oklahoma, 74136, United States
Woden Dermatology

Phillip, Australian Capital Territory, 2606, Australia
Xiangya Hospital Central South University

Changsha, Hunan, 410008, China
Yamaguchi University Hospital

Ube, Yamaguchi, 755-8505, Japan
Yokohama Rosai Hospital

Yokohama, Kanagawa, 222-0036, Japan
Zhejiang Provincial People's Hospital

Hangzhou, Zhejiang, 310014, China

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