New hope for kids with resistant cancers: drug combo shows promise
NCT ID NCT04238819
First seen Nov 01, 2025 · Last updated Apr 25, 2026 · Updated 24 times
Summary
This study tested the safety and effectiveness of adding the drug abemaciclib to standard chemotherapy for children and young adults (up to age 18) whose solid tumors, including neuroblastoma, had stopped responding to treatment or had grown. The goal was to find the best dose and see if the combination could shrink tumors. The study lasted up to 2 years per participant and involved 47 people.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for REFRACTORY SOLID TUMOR are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Atrium Health - Carolinas Medical Center
Charlotte, North Carolina, 28203, United States
-
Centre Leon Berard
Lyon, Rhône, 69373 CEDEX 08, France
-
Charité Campus Virchow-Klinikum
Berlin, 13353, Germany
-
Children's Hospital of Philadelphia (CHOP)
Philadelphia, Pennsylvania, 19104, United States
-
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
-
Cohen Children's Medical Center
New Hyde Park, New York, 11040, United States
-
Fondazione Policlinico Universitario Agostino Gemelli
Rome, Lazio, 168, Italy
-
Gustave Roussy
Villejuif, Val-de-Marne, 94800, France
-
Hospital Infantil Universitario Niño Jesús
Madrid, Madrid, Comunidad de, 28009, Spain
-
Hospital Universitari Vall d'Hebron
Barcelona, Barcelona [Barcelona], 8035, Spain
-
Hospital Universitari i Politecnic La Fe
Valencia, 46026, Spain
-
Institut Curie
Paris, 75248, France
-
Kaiser Permanente Oakland
Oakland, California, 94611, United States
-
Kaiser Permanente Roseville
Roseville, California, 95661, United States
-
Kaiser Permanente Santa Clara
Santa Clara, California, 95051, United States
-
Lifespan Cancer Institute
Providence, Rhode Island, 02906, United States
-
National Cancer Center Hospital
Chuo Ku, Tokyo, 104-0045, Japan
-
Perth Children's Hospital
Perth, Western Australia, 6009, Australia
-
Phoenix Children's Hospital
Phoenix, Arizona, 85016, United States
-
Riley Hospital for Children at Indiana University Health
Indianapolis, Indiana, 46202, United States
-
Spectrum Health
Grand Rapids, Michigan, 49503, United States
-
The Regents of the University of California - Los Angeles (UCLA Pediatrics)
Los Angeles, California, 90095-1752, United States
-
UZ Gent
Ghent, Oost-Vlaanderen, 9000, Belgium
-
Universitaetsklinikum Essen
Essen, North Rhine-Westphalia, 45122, Germany
-
Universitaetsklinikum Heidelberg
Heidelberg, Baden-Wurttemberg, 69120, Germany
Conditions
Explore the condition pages connected to this study.