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New hope for kids with resistant cancers? drug combo shows promise in early trial

NCT ID NCT04238819

Completed Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested the safety and effectiveness of the drug abemaciclib combined with other cancer medicines in 47 children and young adults whose solid tumors (including neuroblastoma) had stopped responding to standard treatments. The goal was to find the best dose and see if the combination could shrink tumors. The study lasted up to 2 years per participant and focused on managing the disease rather than providing a cure.

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Conditions

The condition(s) this trial relates to.

brain cancer diffuse intrinsic pontine glioma ependymoma Ewing sarcoma glioblastoma glioma medulloblastoma neuroblastoma osteosarcoma refractory malignant neoplasm rhabdoid tumor rhabdomyosarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

REFRACTORY SOLID TUMOR RELAPSED SOLID TUMOR

Contacts and locations

Locations

  • Atrium Health - Carolinas Medical Center

    Charlotte, North Carolina, 28203, United States

  • Centre Leon Berard

    Lyon, Rhône, 69373 CEDEX 08, France

  • Charité Campus Virchow-Klinikum

    Berlin, 13353, Germany

  • Children's Hospital of Philadelphia (CHOP)

    Philadelphia, Pennsylvania, 19104, United States

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio, 45229, United States

  • Cohen Children's Medical Center

    New Hyde Park, New York, 11040, United States

  • Fondazione Policlinico Universitario Agostino Gemelli

    Rome, Lazio, 168, Italy

  • Gustave Roussy

    Villejuif, Val-de-Marne, 94800, France

  • Hospital Infantil Universitario Niño Jesús

    Madrid, Madrid, Comunidad de, 28009, Spain

  • Hospital Universitari Vall d'Hebron

    Barcelona, Barcelona [Barcelona], 8035, Spain

  • Hospital Universitari i Politecnic La Fe

    Valencia, 46026, Spain

  • Institut Curie

    Paris, 75248, France

  • Kaiser Permanente Oakland

    Oakland, California, 94611, United States

  • Kaiser Permanente Roseville

    Roseville, California, 95661, United States

  • Kaiser Permanente Santa Clara

    Santa Clara, California, 95051, United States

  • Lifespan Cancer Institute

    Providence, Rhode Island, 02906, United States

  • National Cancer Center Hospital

    Chuo Ku, Tokyo, 104-0045, Japan

  • Perth Children's Hospital

    Perth, Western Australia, 6009, Australia

  • Phoenix Children's Hospital

    Phoenix, Arizona, 85016, United States

  • Riley Hospital for Children at Indiana University Health

    Indianapolis, Indiana, 46202, United States

  • Spectrum Health

    Grand Rapids, Michigan, 49503, United States

  • The Regents of the University of California - Los Angeles (UCLA Pediatrics)

    Los Angeles, California, 90095-1752, United States

  • UZ Gent

    Ghent, Oost-Vlaanderen, 9000, Belgium

  • Universitaetsklinikum Essen

    Essen, North Rhine-Westphalia, 45122, Germany

  • Universitaetsklinikum Heidelberg

    Heidelberg, Baden-Wurttemberg, 69120, Germany

More trials for these conditions

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