Could a drug stop Alzheimer's before symptoms start?

NCT ID NCT02008357

Completed Prevention Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This trial tests whether solanezumab, an antibody that targets amyloid plaques in the brain, can slow the progression of memory problems in people who have no symptoms but show early signs of Alzheimer's-related brain changes. Participants are older adults with normal thinking and memory but with a PET scan showing amyloid buildup. The study compares solanezumab to a placebo to see if the drug can preserve cognitive function over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: solanezumab (an investigational antibody that targets amyloid plaques in the brain)
What this could lead to: If successful, this could lead to a treatment that delays or prevents memory loss in people at risk for Alzheimer's disease.
What could go wrong: This is an early-stage test in people without symptoms, and it may not slow memory decline. The drug also carries risks like brain swelling or bleeding, which the trial monitors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognition Disorders cognitive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COGNITION DISORDERS

Contacts and locations

Locations

Banner Health Research Institute

Phoenix, Arizona, 85006, United States
Banner Sun Health Research Institute

Sun City, Arizona, 85351, United States
Barrow Neurological Institute

Phoenix, Arizona, 85013, United States
Baylor College of Medicine

Houston, Texas, 77030, United States
Boston University Medical Center

Boston, Massachusetts, 02118, United States
Brain Matters Research

Delray Beach, Florida, 33445, United States
Brigham and Womens Hospital

Boston, Massachusetts, 02115, United States
Butler Hospital

Providence, Rhode Island, 02906, United States
Case Western Reserve University

Beachwood, Ohio, 44122, United States
Cleveland Clinic of Las Vegas

Las Vegas, Nevada, 89106, United States
Columbia University Medical Center

New York, New York, 10032, United States
Compass Research - Orlando

Orlando, Florida, 32806, United States
Compass Research -The Villages

The Villages, Florida, 32162, United States
Dent Neurological Institute

Amherst, New York, 14226, United States
Drexel University College of Medicine at EPPI

Philadelphia, Pennsylvania, 19102, United States
Emory University

Atlanta, Georgia, 30322, United States
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.

Parkville, Victoria, 3010, Australia
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.

Bunkyō City, 113-8655, Japan
For additional information regarding investigative sites for this trial, contact 1-888-545-5972 Mon - Fri, 9 AM to 4 PM or 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri, 9 AM to 5 PM Eastern Time or speak with your personal physician.

London, N6C 0A7, Canada
For additional information regarding investigative sites for this trial, contact 1-888-545-5972 Mon - Fri, 9 AM to 4 PM or 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri, 9 AM to 5 PM Eastern Time or speak with your personal physician.

Toronto, M3B2S7, Canada
For additional information regarding investigative sites for this trial, contact 1-888-545-5972 Mon - Fri, 9 AM to 4 PM or 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri, 9 AM to 5 PM Eastern Time or speak with your personal physician.

Vancouver, V6T 2B5, Canada
Georgetown University Hospital

Washington D.C., District of Columbia, 20057, United States
Great Lakes Clinical Trials

Chicago, Illinois, 60640, United States
Houston Methodist

Houston, Texas, 77030, United States
Howard University Hospital

Washington D.C., District of Columbia, 20060, United States
Indiana University School of Medicine

Indianapolis, Indiana, 46202, United States
Institute for Memory Impairment & Neurological Disorders

Irvine, California, 92697, United States
Johns Hopkins University School of Medicine

Baltimore, Maryland, 21093, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Mayo Clinic-Jacksonville

Jacksonville, Florida, 32224, United States
Mount Sinai School of Medicine

New York, New York, 10029, United States
New York University Medical Center

New York, New York, 10016, United States
Northwestern University

Chicago, Illinois, 60611, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Pennington Biomedical Research Center

Baton Rouge, Louisiana, 70808-4124, United States
Premiere Research Institute at Palm Beach Neurology

West Palm Beach, Florida, 33407, United States
Rhode Island Hospital

Providence, Rhode Island, 02906, United States
Roper Hospital

Charleston, South Carolina, 29401, United States
Rush Alzheimer's Disease Center

Chicago, Illinois, 60612, United States
Sunnybrook Health Sciences Centre

Toronto, M4N 3M5, Canada
Sutter Medical Group

Sacramento, California, 95816, United States
Syrentis Clinical Research

Santa Ana, California, 92705, United States
Tulsa Clinical Research LLC

Tulsa, Oklahoma, 74104, United States
Univ of California Irvine College of Medicine

Orange, California, 92868, United States
Univ of California San Francisco

San Francisco, California, 94158, United States
Univ of Nebraska Med Center

Omaha, Nebraska, 68198, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States
University of California - Los Angeles

Los Angeles, California, 90095, United States
University of California - San Diego

La Jolla, California, 92037, United States
University of California, Davis - Health Systems

Walnut Creek, California, 94598, United States
University of Iowa

Iowa City, Iowa, 52242, United States
University of Kansas Hospital

Fairway, Kansas, 66205, United States
University of Kentucky

Lexington, Kentucky, 40504, United States
University of Michigan

Ann Arbor, Michigan, 48105, United States
University of Pennsylvania Hospital

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15213, United States
University of Rochester

Rochester, New York, 14620, United States
University of South Florida

Tampa, Florida, 33613, United States
University of Southern California School of Medicine

Los Angeles, California, 90033, United States
University of Texas Southwestern Medical Center at Dallas

Dallas, Texas, 75235, United States
University of Washington School of Medicine

Seattle, Washington, 98108, United States
University of Wisconsin-Madison Hospital and Health Clinic

Madison, Wisconsin, 53705, United States
Veterans Affairs Medical Center Palo Alto

Palo Alto, California, 94304, United States
Wake Forest University School of Medicine

Winston-Salem, North Carolina, 27157, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Weill Cornell Medical College

New York, New York, 10021, United States
Wien Center for Clinical Research

Miami Beach, Florida, 33140, United States
Yale University School of Medicine

New Haven, Connecticut, 06510, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.