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New combo shows promise for lung cancer patients

NCT ID NCT01897480

Completed Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding a new drug (LY2875358) to the standard treatment erlotinib helps people with advanced non-small cell lung cancer that has a specific gene mutation. All 168 participants first took erlotinib alone for 8 weeks. Those whose cancer did not worsen were then randomly assigned to continue erlotinib alone or add the new drug. The goal was to see if the combination delayed cancer growth longer than erlotinib alone.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA, NON-SMALL-CELL LUNG

Contacts and locations

Locations

  • Asan Medical Center

    Seoul, Seoul-teukbyeolsi [Seoul], 05505, South Korea

  • Azienda Ospedaliera Universitaria Careggi

    Florence, Florence, 50134, Italy

  • Azienda Sanitaria Ospedaliera S Luigi Gonzaga

    Orbassano, Torino, 10043, Italy

  • CHU De Grenoble Hopital Albert Michallon

    Grenoble, 38043, France

  • CHU de Caen Hopital Cote de Nacre

    Caen, 14033, France

  • CHU la Miletrie

    Poitiers, 86021, France

  • Charing Cross Hospital

    Chelsea, London, W6 8RF, United Kingdom

  • China Medical University Hospital

    Taichung, 40447, Taiwan

  • Chu Gabriel Montpied

    Clermont-Ferrand, 63000, France

  • Chungbuk National University Hospital

    Cheongju-si, Chungcheongbuk-do [Chungbuk], 28644, South Korea

  • Churchill Hospital

    Oxford, OX3 7LJ, United Kingdom

  • Clinica Universitaria De Navarra

    Pamplona, Navarre, 31008, Spain

  • Corporacion Sanitaria Parc Tauli

    Sabadell, Barcelona, 08208, Spain

  • Gachon University Gil Medical Center

    Namdong-gu, Incheon-gwangyeoksi [Incheon], 21565, South Korea

  • Gartnavel General Hospital

    Glasgow, Glasgow City, G12OYN, United Kingdom

  • HCL-Hôpital Louis Pradel

    Lyon (Bron) Cedex, 69677, France

  • Helios Klinikum Emil von Behring Berlin-Zehlendorf

    Berlin, 14165, Germany

  • Herlev and Gentofte Hospital

    Herlev, Capital Region, 2730, Denmark

  • Hospital Puerta De Hierro

    Majadahonda, Madrid, 28222, Spain

  • Hospital Universitario Quironsalud Madrid

    Pozuelo de Alarcón, Madrid, 28223, Spain

  • Hospital del Mar

    Barcelona, 08003, Spain

  • Hôpital Arnaud de Villeneuve - CHU Montpellier

    Montpellier, 34295, France

  • Istituti Ospedalieri di Cremona

    Cremona, 26100, Italy

  • Istituto Oncologico Veneto IRCCS

    Padova, Veneto, 35128, Italy

  • Istituto Tumori ""Giovanni Paolo II

    Bari, 70124, Italy

  • Jeroen Bosch Hospital

    's-Hertogenbosch, North Brabant, 5223 GZ, Netherlands

  • Klinik Schillerhöhe

    Gerlingen, Baden-Wurttemberg, 70839, Germany

  • Klinikum Köln-Merheim

    Cologne, North Rhine-Westphalia, 51109, Germany

  • National Taiwan University Hospital

    Taipei, 10002, Taiwan

  • New Cross Hospital

    Wolverhampton, West Midlands, WV10 0QP, United Kingdom

  • Odense Universitetshospital

    Odense C, Syd, 5000, Denmark

  • Rigshospitalet

    Copenhagen, Copenhagen, 2100, Denmark

  • Samsung Medical Center

    Seoul, Seoul-teukbyeolsi [Seoul], 06351, South Korea

  • Seoul National University Bundang Hospital

    Seongnam, Kyǒnggi-do, 13620, South Korea

  • Severance Hospital, Yonsei University Health System

    Seoul, Korea, 03722, South Korea

  • St. Antonius Ziekenhuis, locatie Nieuwegein

    Nieuwegein, 3435 CM, Netherlands

  • Taichung Veterans General Hospital

    Taichung, 40705, Taiwan

  • Taipei Veterans General Hospital

    Taipei, 11217, Taiwan

  • Thoraxklinik-Heidelberg gGmbH

    Heidelberg, Baden-Wurttemberg, 69126, Germany

  • Ulsan University Hospital

    Ulsan, Ulsan-Kwangyǒkshi, 44033, South Korea

  • Universitätsklinikum Schleswig-Holstein

    Lübeck, Schleswig-Holstein, 23538, Germany

  • Universitätsklinikum Ulm

    Ulm, Baden-Wurttemberg, 89075, Germany

  • Wythenshawe Hospital

    Wythenshawe, Manchester, M23 9LT, United Kingdom

  • Ziekenhuis Rijnstate

    Arnhem, 6815 AD, Netherlands

  • Ziekenhuis St. Jansdal

    Harderwijk, 3844 DG, Netherlands

More trials for these conditions

Other studies related to the condition(s) this trial covers.