New drug takes aim at Hard-to-Treat blood cancers
NCT ID NCT07101328
First seen Jun 25, 2026 · Last updated Jul 10, 2026 · Updated 2 times
Summary
This early-stage trial tests a new drug called LY4152199 in about 215 adults with certain types of blood cancer (like follicular lymphoma or diffuse large B-cell lymphoma) that have already been treated. The drug is designed to help the body's immune cells attack the cancer. The main goals are to find a safe dose and to see if the drug can shrink tumors. Participants may continue treatment as long as they benefit.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- LY4152199 (a drug that helps immune cells attack cancer cells)
- What this could lead to
- If it works, this could point toward a new treatment option for people with certain types of blood cancer that have not responded to other therapies.
- What could go wrong
- This is a very early (Phase 1) trial, so the main goal is safety, not proof of effectiveness. The drug may not work or could cause serious side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for B CELL LYMPHOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
AIDPORT Sp. z o.o.
NOT_YET_RECRUITINGSkorzewo, 60-185, Poland
-
AP-HP Hopital Saint-Louis
NOT_YET_RECRUITINGParis, 75010, France
-
Aarhus University Hospital
NOT_YET_RECRUITINGAarhus, N 8200, Denmark
-
Asan Medical Center
NOT_YET_RECRUITINGSeoul, 05505, South Korea
-
BC Cancer - Vancouver
NOT_YET_RECRUITINGVancouver, V5Z 1L3, Canada
-
CHU de Lille - Hopital Claude Huriez
NOT_YET_RECRUITINGLille, 59037, France
-
Center for Cancer and Organ Diseases - Rigshospitalet
NOT_YET_RECRUITINGCopenhagen, 2100, Denmark
-
Charite Universitaetsmedizin Berlin
NOT_YET_RECRUITINGBerlin, 10117, Germany
-
City of Hope
RECRUITINGDuarte, California, 91010, United States
-
Cleveland Clinic
NOT_YET_RECRUITINGCleveland, Ohio, 44195, United States
-
Colorado Blood Cancer Institute
RECRUITINGDenver, Colorado, 80218, United States
-
Dana-Farber Cancer Institute
NOT_YET_RECRUITINGBoston, Massachusetts, 02215, United States
-
David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
-
Froedtert Hospital and the Medical College of Wisconsin
NOT_YET_RECRUITINGMilwaukee, Wisconsin, 53226, United States
-
Hospital Universitario Vall d'Hebron
NOT_YET_RECRUITINGBarcelona, 08035, Spain
-
IRCCS Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant Orsola
NOT_YET_RECRUITINGBologna, 40138, Italy
-
Institut Catala d'Oncologia - L'Hospitalet
NOT_YET_RECRUITINGBarcelona, 08908, Spain
-
Intermountain Healthcare
NOT_YET_RECRUITINGSalt Lake City, Utah, 84111, United States
-
Istituto Clinico Humanitas
NOT_YET_RECRUITINGRozzano, 20089, Italy
-
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale
NOT_YET_RECRUITINGNaples, 80131, Italy
-
LMU Klinikum Muenchen-Campus Grosshadern
NOT_YET_RECRUITINGMünchen, 80336, Germany
-
Lady Davis Institute for Medical Research Jewish General Hospital
NOT_YET_RECRUITINGMontreal, H3T 1E2, Canada
-
Leeds Teaching Hospitals NHS Trust
NOT_YET_RECRUITINGLeeds, LS9 7TF, United Kingdom
-
Linear Clinical Research
NOT_YET_RECRUITINGNedlands, 6009, Australia
-
MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
-
Massachusetts General Hospital
NOT_YET_RECRUITINGBoston, Massachusetts, 02114, United States
-
Mayo Clinic - Rochester
RECRUITINGRochester, Minnesota, 55905, United States
-
National Cancer Center Hospital East
NOT_YET_RECRUITINGChiba, 277-8577, Japan
-
New York University (NYU) Clinical Cancer Center
RECRUITINGNew York, New York, 10016, United States
-
Okayama University Hospital
NOT_YET_RECRUITINGOkayama, 700-8558,, Japan
-
Oxford University Hospitals NHS Foundation Trust
NOT_YET_RECRUITINGOxford, OX3 9DU, United Kingdom
-
Pratia MCM Krakow
NOT_YET_RECRUITINGKrakow, 30-727, Poland
-
Rutgers Cancer Institute of New Jersey
NOT_YET_RECRUITINGNew Brunswick, New Jersey, 08903, United States
-
SCRI Oncology Partners
RECRUITINGNashville, Tennessee, 37203, United States
-
Seoul National University Hospital
NOT_YET_RECRUITINGSeoul, 03080, South Korea
-
South Texas Accelerated Research Therapeutics (START) Madrid - Hospital Fundacion Jimenez Diaz
NOT_YET_RECRUITINGMadrid, 28040, Spain
-
Swedish Cancer Institute (SCI)
NOT_YET_RECRUITINGSeattle, Washington, 98104, United States
-
The Alfred Hospital
NOT_YET_RECRUITINGMelbourne, VIC, 3004, Australia
-
The Cancer Institute Hospital of JFCR
NOT_YET_RECRUITINGTokyo, 135-8550, Japan
-
The University of Chicago Medical Center (UCMC)
RECRUITINGChicago, Illinois, 60637, United States
-
Universitaetsklinikum Muenster
NOT_YET_RECRUITINGMünster, 48149, Germany
-
University Health Network (UHN) - Princess Margaret Cancer Centre
NOT_YET_RECRUITINGToronto, M5G 1Z5, Canada
-
University of Colorado Denver - School of Medicine - Anschutz Medical Campus
RECRUITINGAurora, Colorado, 80045-2559, United States
-
University of Iowa
RECRUITINGIowa City, Iowa, 52242, United States
-
University of Kansas Cancer Center
NOT_YET_RECRUITINGKansas City, Kansas, 66160, United States
-
University of Michigan Comprehensive Cancer Center
NOT_YET_RECRUITINGAnn Arbor, Michigan, 48109, United States
-
University of Pennsylvania Abramson Cancer Center
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
-
University of Texas Southwestern
NOT_YET_RECRUITINGDallas, Texas, 75244, United States
-
Weill Cornell Medicine
RECRUITINGNew York, New York, 10021, United States
-
Yale University School of Medicine - Yale Cancer Center
RECRUITINGNew Haven, Connecticut, 06520-8028, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a radioactive drug outperform standard therapy in waldenstrom macroglobulinemia?
- Engineered immune cells take aim at Hard-to-Treat lymphomas
- Can antibody infusions outperform antibiotics in shielding CAR-T patients from infections?
- Can a single shot build a cancer army inside the body?
- Rare childhood bone lymphoma: can past cases guide future care?
- Smartwatches track hidden heart risk in blood cancer patients