Hypertriglyceridemia

This study tested whether the drug RDX-002 can lower high blood fat levels in people who recently stopped taking weight-loss medications like semaglutide or tirzepatide. Sixty-eight adults who had lost at least 10% of their body weight on those drugs took either RDX-002 or a plac…

This study tested a drug called pegozafermin in 369 adults with severe hypertriglyceridemia, a condition where blood fat levels are dangerously high. Participants received either the drug or a placebo for 26 weeks. The main goal was to see if the drug could safely lower triglycer…

This study tested a drug called olezarsen in 154 adults with high triglycerides (a type of blood fat) and either heart disease or very high triglycerides. Participants received injections of the drug or a placebo for up to 12 months. The main goal was to see if the drug could low…

This study tested an experimental drug called ARO-APOC3 in 229 adults with severely high triglycerides (a type of blood fat). Participants received two injections of the drug or a placebo. The goal was to see if the drug could safely lower triglyceride levels. Results showed sign…

This Phase 3 study tested a drug called olezarsen in 1,478 people with very high triglycerides (a type of blood fat) and either heart disease or a high risk for it. Participants received either olezarsen or a placebo as a shot under the skin. The main goal was to see if olezarsen…

This Phase 3 trial tested a drug called olezarsen in 617 people with severe hypertriglyceridemia (very high blood fats). Participants received either the drug or a placebo as a shot under the skin. The main goal was to see if olezarsen could lower triglyceride levels more than pl…

This study tested whether drinking rosemary infusion daily for 6 weeks could help people with mild high blood pressure and high triglycerides. 47 adults took part, and researchers measured blood pressure and blood fats before and after. The goal was to see if this simple herbal d…

This study tested a new drug called DR10624 in 79 adults with severely high triglycerides, a type of blood fat that raises the risk of heart problems. Participants received injections under the skin for 12 weeks. The main goal was to see if the drug safely lowers triglyceride lev…

This early-stage study tested a new medicine called ARO-ANG3 in 93 people, including healthy volunteers and patients with high cholesterol or high triglycerides. The main goal was to check if the drug is safe and how the body processes it. This research helps determine if the dru…

This early-stage study tested a new medicine called ARO-APOC3 in healthy volunteers and people with severely high triglycerides or a rare genetic condition called familial chylomicronemia syndrome. The main goal was to check safety and how the drug moves through the body. The stu…

This Phase 3 trial tested a new combination drug called Cipros 10 against the standard statin Crestor in 146 adults with dyslipidemia (high cholesterol and triglycerides). The goal was to see if Cipros 10 could lower triglyceride levels more effectively. Participants took one pil…

This study tested a new medicine, MAR001, in 55 adults with high triglycerides (a type of fat in the blood) and metabolic problems. The main goal was to see if the drug is safe and tolerable. Researchers also checked if it could lower triglyceride levels. The study was completed …

This study tested a new medicine called olezarsen in 446 people with very high levels of blood fats (triglycerides). The goal was to see if it could lower these fats more than a placebo. Participants received shots under the skin and followed a healthy diet.

This study tested whether low-dose omega-3 supplements (250 mg EPA per day) can improve cholesterol and inflammation in overweight or obese adults with high triglycerides. Forty participants in Chile took omega-3 or a placebo for six weeks each in a crossover design. The goal was…

This study looked at whether taking fish oil and doing high-intensity interval training (HIIT) could lower inflammation in people who are overweight or obese. Researchers measured changes in blood markers of inflammation and metabolism over 10 weeks. The goal was to see if the co…

This early-phase study tested a single dose of VSA003 in 36 healthy Chinese adults to see if it is safe and how the body handles it. The drug aims to help control high cholesterol and triglycerides. Participants received either VSA003 or a placebo, and researchers monitored for s…

This study aimed to find new gene changes that cause rare lipid disorders. Researchers used advanced genetic testing to look at many genes at once in 140 people and their relatives. The goal was to discover causes that older methods missed.

This study looked at whether replacing non-dairy foods with two servings a day of full-fat or low-fat fermented dairy (like yogurt and cheese) could improve insulin sensitivity and other heart health markers. 110 overweight adults with high triglycerides took part. The goal was t…

This completed study looked at how a low-calorie diet changes the activity of certain genes in white blood cells and affects heart health markers in 60 people with high triglycerides and overweight. Researchers compared those who lost more weight to those who lost less, to unders…

This study looked at how the body processes cortisol in people with a rare genetic condition called familial partial lipodystrophy type 2 (FPL2). The goal was to see if increased activity of a certain enzyme (11β-HSD1) contributes to the severe metabolic problems seen in this dis…

This study looked at how many girls and young women aged 11 to 20 with chronic diseases (like diabetes or immune conditions) got the HPV vaccine, compared to those without chronic illness. Researchers reviewed records of 223 participants from a hospital in France. The goal was to…