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New injection shows promise for dangerous high fat levels

NCT ID NCT04720534

Completed Disease control Sponsor: Arrowhead Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 28 times

Summary

This study tested an experimental drug called ARO-APOC3 in 229 adults with severely high triglycerides (a type of blood fat). Participants received two injections of the drug or a placebo. The main goal was to see if the drug safely lowers triglyceride levels after 24 weeks, with follow-up through 48 weeks.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Research Site 10

    Miami, Florida, 33144, United States

  • Research Site 11

    Miami, Florida, 33155, United States

  • Research Site 12

    Miami Springs, Florida, 33166, United States

  • Research Site 14

    Port Orange, Florida, 32127, United States

  • Research Site 16

    Dunwoody, Georgia, 30338, United States

  • Research Site 17

    Arlington Heights, Illinois, 60005, United States

  • Research Site 18

    Lexington, Kentucky, 40503, United States

  • Research Site 2

    Beverly Hills, California, 90211, United States

  • Research Site 20

    Minneapolis, Minnesota, 55455, United States

  • Research Site 21

    Tupelo, Mississippi, 38801, United States

  • Research Site 22

    Kalispell, Montana, 59901, United States

  • Research Site 23

    Omaha, Nebraska, 68114, United States

  • Research Site 24

    Las Vegas, Nevada, 89121, United States

  • Research Site 25

    Long Island City, New York, 11106, United States

  • Research Site 26

    New Windsor, New York, 12553, United States

  • Research Site 27

    New York, New York, 10029, United States

  • Research Site 29

    Morehead City, North Carolina, 28557, United States

  • Research Site 30

    Fargo, North Dakota, 58104, United States

  • Research Site 31

    Dayton, Ohio, 45419, United States

  • Research Site 32

    Franklin, Ohio, 45005, United States

  • Research Site 33

    Maumee, Ohio, 43537, United States

  • Research Site 34

    Oklahoma City, Oklahoma, 73135, United States

  • Research Site 35

    Greenville, South Carolina, 29607, United States

  • Research Site 36

    Chattanooga, Tennessee, 37421, United States

  • Research Site 38

    Houston, Texas, 77030, United States

  • Research Site 39

    Houston, Texas, 77099, United States

  • Research Site 4

    Palm Springs, California, 92292, United States

  • Research Site 40

    San Antonio, Texas, 78249, United States

  • Research Site 41

    Manassas, Virginia, 20110, United States

  • Research Site 42

    Camperdown, New South Wales, 2050, Australia

  • Research Site 43

    Perth, Nedlands, 6009, Australia

  • Research Site 44

    Brisbane, Queensland, 4064, Australia

  • Research Site 45

    Sippy Downs, Queensland, 4556, Australia

  • Research Site 46

    Adelaide, South Australia, 5000, Australia

  • Research Site 47

    Clayton, Victoria, 3168, Australia

  • Research Site 49

    Concord, Ontario, L4K 4M2, Canada

  • Research Site 5

    Boca Raton, Florida, 33434, United States

  • Research Site 50

    London, Ontario, N6A 5A5, Canada

  • Research Site 51

    Toronto, Ontario, M4G 3E8, Canada

  • Research Site 52

    Chicoutimi, Quebec, G7H5H6, Canada

  • Research Site 53

    Greenfield, Quebec, J4V2G8, Canada

  • Research Site 54

    Montreal, Quebec, H2W2T2, Canada

  • Research Site 55

    Aachen, 52074, Germany

  • Research Site 56

    Leipzig, 0 4103, Germany

  • Research Site 57

    Baja, 6500, Hungary

  • Research Site 58

    Baja, 6500, Hungary

  • Research Site 59

    Balatonföldvár, H-8230, Hungary

  • Research Site 6

    Fort Lauderdale, Florida, 33308, United States

  • Research Site 60

    Békéscsaba, 5600, Hungary

  • Research Site 61

    Debrecen, 4032, Hungary

  • Research Site 62

    Gyöngyös, 3200, Hungary

  • Research Site 63

    Komárom, 2921, Hungary

  • Research Site 64

    Nyíregyháza, 4405, Hungary

  • Research Site 65

    Nyíregyháza, 4400, Hungary

  • Research Site 66

    Amsterdam, 1105 AZ, Netherlands

  • Research Site 67

    Dordrecht, 3318 AT, Netherlands

  • Research Site 68

    Sneek, 08601, Netherlands

  • Research Site 69

    Christchurch, 8011, New Zealand

  • Research Site 70

    Hamilton, 3200, New Zealand

  • Research Site 71

    Papatoetoe, 2025, New Zealand

  • Research Site 72

    Rotorua, 3010, New Zealand

  • Research Site 73

    Grafton, Auckland, 1010, New Zealand

  • Research Site 74

    Bydgoszcz, 85-605, Poland

  • Research Site 75

    Elblag, 82-300, Poland

  • Research Site 76

    Gdynia, 81-157, Poland

  • Research Site 77

    Łęczyca, 99-100, Poland

  • Research Site 78

    Oświęcim, 32-600, Poland

  • Research Site 79

    Poznan, 61-655, Poland

  • Research Site 8

    Miami, Florida, 33173, United States

  • Research Site 80

    Puławy, 24-100, Poland

  • Research Site 81

    Rzeszów, 35-055, Poland

  • Research Site 82

    Wołomin, 05-200, Poland

  • Research Site 83

    Lodz, 94-048, Poland

  • Research Site 9

    Miami, Florida, 33144, United States

Conditions

Explore the condition pages connected to this study.

SEVERE HYPERTRIGLYCERIDEMIA