Hypertriglyceridemia

This phase 3 trial tests an investigational injectable drug called DR10624 in adults with severe hypertriglyceridemia (very high blood fats) that remains high despite standard treatment. Participants continue their usual omega-3 therapy and receive weekly injections of DR10624 or…

This early study tests a new gene-editing treatment called CS-121 in 15 adults with severe high triglycerides (a type of fat in the blood) that hasn't been controlled by standard treatments. The therapy uses tiny fat particles to deliver a gene editor that targets the APOC3 gene …

This early-stage study tests a new medicine called ISH0688, given as a shot under the skin, for people with high triglycerides (a type of blood fat). The study will involve 104 healthy volunteers and people with high triglycerides to check the drug's safety and how the body proce…

This study tests whether semaglutide (Ozempic/Wegovy) can prevent repeat episodes of acute pancreatitis caused by very high triglycerides. About 396 adults who recently had such an attack will receive either semaglutide injections or a placebo for 18 months, alongside standard ca…

This 10-year observational study will follow 10,000 adults with diabetes, metabolic disorders, and related conditions like high blood pressure and fatty liver disease. Researchers will collect routine medical data to identify markers of disease severity and activity. The goal is …