Gene-Editing shot aims to slash dangerous fat levels in blood
NCT ID NCT07657780
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early study tests a new gene-editing treatment called CS-121 in 15 adults with severe high triglycerides (a type of fat in the blood) that hasn't been controlled by standard treatments. The therapy uses tiny fat particles to deliver a gene editor that targets the APOC3 gene in the liver, aiming to lower fat levels. The main goal is to check safety and side effects, while also seeing if it reduces triglycerides and related proteins.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CS-121 (a gene-editing therapy delivered by lipid nanoparticles to edit the APOC3 gene)
What this could lead to
If it works, this could point toward a one-time treatment that controls severe high triglycerides by editing a gene, potentially reducing the need for daily medication.
What could go wrong
This is a very early, small trial (15 people) focused on safety, not yet on effectiveness. The therapy is new and may not work as hoped, and there are unknown risks from gene editing.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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The First Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China
Contact Phone: •••-•••-•••• Email: •••••@•••••