Hypertriglyceridemia

This Phase 3 study tests plozasiran, an injectable drug, in 1456 adults with high triglycerides. Participants receive 4 doses over 12 months. The goal is to see if the drug safely lowers blood fat levels compared to a placebo.

This study gives the drug metreleptin to 29 people with partial lipodystrophy, a rare condition that causes high blood fats and diabetes. Participants have already shown improvement from the drug in earlier studies. The goal is to keep providing the treatment and check its long-t…

This study gives the drug metreleptin to people with generalized lipodystrophy, a rare condition that causes severe fat loss and leads to high blood fats and diabetes. Participants, aged 6 months and older, have already received metreleptin in past NIH studies but cannot get it i…

This study tests an injected drug called DR10624 in 40 adults with high triglycerides and fatty buildup in their neck arteries. Participants receive either the drug or a placebo for 24 weeks, with doses gradually increased. The main goal is to see if the drug reduces artery wall …

This study looks at whether taking omega-3 fatty acid supplements can help lower very high triglyceride levels in pregnant women. High triglycerides during pregnancy can increase the chance of having a large baby. The study involves 40 pregnant women with elevated triglycerides a…

This Phase 2b study tests whether the experimental drug MAR001 can lower high triglycerides and remnant cholesterol in adults. About 216 participants will receive either MAR001 or a placebo by injection. The main goal is to see if MAR001 reduces triglyceride levels more than plac…

This study tests whether whole-body electromyostimulation (WB-EMS), a technology that stimulates muscles with mild electrical pulses, can lower resting blood pressure and improve other heart risk factors in overweight adults aged 50+ with mild hypertension. Over 12 weeks, 28 part…

This study tests whether a probiotic called Limosilactobacillus fermentum CRL 1446 can improve health in 80 adults with heart disease risk factors like obesity, high blood pressure, and high cholesterol. Participants take either the probiotic or a placebo daily, and researchers m…

This study tests the safety of switching from the current drug metreleptin to a new experimental drug called mibavademab in people with generalized lipodystrophy, a rare condition where the body cannot properly store fat. Nine participants who have been stable on metreleptin will…

This early-stage study tests a new drug called Kylo-12 in 50 healthy volunteers to see if it is safe and how the body processes it. The drug aims to lower high triglycerides, a type of fat in the blood linked to heart problems. Participants receive either a single shot of Kylo-12…

This phase 2 trial tests an oral drug called MN-001 (tipelukast) in 40 adults with non-alcoholic fatty liver disease, type 2 diabetes, and high triglycerides. Participants take either the drug or a placebo daily for 24 weeks. The study measures changes in liver fat and blood fat …

This study tests a single dose of a new drug called RN0361 in 108 adults. It includes healthy volunteers and people with very high triglycerides, a type of fat in the blood that can cause serious health problems. The goal is to see if the drug is safe and lowers fat levels. This …

This study looks at whether a protein supplement called carnitine can reduce hardening of the arteries in teenagers at high risk for future heart disease. About 90 teens aged 11-21 with high triglycerides will take carnitine or a placebo. Researchers will measure artery stiffness…

This study tests the long-term safety of a drug called olezarsen in people with severely high triglycerides, a condition that raises the risk of pancreatitis and heart disease. About 885 participants who completed earlier studies will receive olezarsen injections for up to three …

This program provides evinacumab to children with homozygous familial hypercholesterolemia (HoFH) or severe high triglycerides when standard treatments don't work. The drug helps lower dangerous fat levels in the blood, but patients must keep taking it long-term to control their …

This Phase 3 trial tests plozasiran, an injectable drug, in 446 adults with severe hypertriglyceridemia (very high blood fats). Participants receive four doses over 12 months, and researchers measure how much triglyceride levels drop compared to placebo. The goal is to see if plo…

This Phase 3 study tests a drug called plozasiran in 311 adults with severe hypertriglyceridemia, a condition where blood fat levels are very high and raise the risk of pancreatitis. Participants receive four injections over a year, either the drug or a placebo. The main goal is …