Can breathing pure oxygen boost stroke recovery?

NCT ID NCT06666764

Recruiting now Disease control Sponsor: Capital Medical University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving patients 100% oxygen (normobaric hyperoxia) before a clot-removal procedure can improve their recovery three months after a severe stroke. About 1,500 adults with acute ischemic stroke will be randomly assigned to receive either the extra oxygen or standard care alone. The goal is to see if this simple, low-cost approach reduces long-term disability.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 100% oxygen (normobaric hyperoxia)
What this could lead to: If it works, this could provide a simple, low-cost way to improve functional recovery after a severe stroke.
What could go wrong: This is a large Phase 3 trial, but the intervention is an add-on to standard care, so any benefit may be modest. Oxygen therapy also carries risks like lung irritation or worsened brain injury in some cases.

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Conditions

The condition(s) this trial relates to.

ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ISCHEMIC STROKE

Contacts and locations

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Locations

Anyi County People's Hospital
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Nanchang, Jiangxi, China
Baoji High-Tech Hospital
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Baoji, Shaanxi, China
Binchuan County People's Hospital
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Dali, Yunnan, China
Binchuan County Traditional Chinese Medicine Hospital
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Dali, Yunnan, China
Caijiapo Hospital
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Baoji, Shaanxi, China
Cangzhou Central Hospital
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Cangzhou, Hebei, China
Chenggong District People's Hospital
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Kunming, Yunnan, China
Dali Prefecture People's Hospital
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Dali, Yunnan, China
Daming County Traditional Chinese Medicine Hospital
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Handan, Hebei, China
Danchuan Central Hospital
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Zhoukou, Hennan, China
Danchuan County Traditional Chinese Medicine Hospital
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Zhoukou, Henan, China
Dean County People's Hospital
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Jiujiang, Jiangxi, China
Dean County Traditional Chinese Medicine Hospital
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Jiujiang, Jiangxi, China
Dexing People's Hospital
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Dexing, Jiangxi, China
Dongguang County People's Hospital
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Cangzhou, Hebei, China
Dongshan County Hospital
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Zhangzhou, Fujian, China
Feicheng Hospital of Shandong Yiyang Health Group
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Tai’an, Shandong, China
Fengxin County People's Hospital
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Yichun, Jiangxi, China
Fuchuan Yao Autonomous County Ethnic Medicine Hospital
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Hezhou, Guangxi, China
Fujian Medical University First Affiliated Hospital
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Fuzhou, Fujian, China
Fujian Medical University Union Hospital
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Fuzhou, Fujian, China
Fujian Minhou County Hospital
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Fuzhou, Fujian, China
Fuqing Hospital
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Fuzhou, Fujian, China
Fuqing Second Hospital
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Fuzhou, Fujian, China
Fuyuan County People's Hospital
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Qujing, Yunnan, China
Fuzhou Changle District People's Hospital
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Fuzhou, Fujian, China
Fuzhou Traditional Chinese Medicine Hospital
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Fuzhou, Fujian, China
Guangchang County People's Hospital
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Fuzhou, Jiangxi, China
Guangzhou Development District Hospital
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Guangzhou, Guangdong, China
Guangzhou He Xian Memorial Hospital
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Guangzhou, Guangdong, China
Gutian County Hospital
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Ningde, Fujian, China
Handan Central Hospital (East Campus)
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Handan, Hebei, China
Handan Fourth Hospital
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Handan, Hebei, China

Contact Email: •••••@•••••
Heqing County People's Hospital
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Dali, Yunnan, China
Hezhou Traditional Chinese Medicine Hospital
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Hezhou, Guangxi, China
Huangmei County People's Hospital
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Huanggang, Hubei, China
Hubei Minzu University Affiliated Minzu Hospital
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Enshi, Hubei, China
Hukou County People's Hospital
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Jiujiang, Jiangxi, China
Jianchuan County People's Hospital
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Dali, Yunnan, China
Jiangxi Provincial People's Hospital
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Nanchang, Jiangxi, China
Jinan University First Affiliated Hospital
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Guangzhou, Guangdong, China
Jincheng First People's Hospital
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Jinzhong, Shanxi, China
Jinning District People's Hospital
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Kunming, Yunnan, China
Jinxi County People's Hospital
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Fuzhou, Jiangxi, China
Jiujiang First People's Hospital
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Jiujiang, Jiangxi, China
Kunming Medical University Yan'an Hospital
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Kunming, Yunnan, China
Lianjiang County General Hospital
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Fuzhou, Fujian, China
Liaocheng People's Hospital
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Liaocheng, Shandong, China
Lichuan Traditional Chinese Medicine Hospital
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Lichuan, Hubei, China
Linkou County People's Hospital
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Mudanjiang, Heilongjiang, China
Linzhang County People's Hospital
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Handan, Hebei, China
Longxian People's Hospital
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Baoji, Shaanxi, China
Luoyang Central Hospital
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Luoyang, Henan, China

Contact Email: •••••@•••••
Luoyuan County Hospital
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Fuzhou, Fujian, China
Lushan People's Hospital
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Lushancun, Jiangxi, China
Luyi Zhenyuan Hospital
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Zhoukou, Henan, China
Meixian Traditional Chinese Medicine Hospital
NOT_YET_RECRUITING

Baoji, Shaanxi, China
Midu County People's Hospital
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Dali, Yunnan, China
Minqing County General Hospital
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Fuzhou, Fujian, China
Mudanjiang Second People's Hospital
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Mudanjiang, Heilongjiang, China
Nanjian Yi Autonomous County People's Hospital
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Dali, Yunnan, China
Nanjing County Hospital
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Zhangzhou, Fujian, China
Pengze County People's Hospital
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Jiujiang, Jiangxi, China
Pinghe County Hospital
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Zhangzhou, Fujian, China
Poyang County People's Hospital
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Shangrao, Jiangxi, China
Putian Hanjiang District Hospital
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Putian, Fujian, China
Quzhou County Hospital
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Handan, Hebei, China
Shanggao County People's Hospital
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Yichun, Jiangxi, China
Shanxi Provincial People's Hospital
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Taiyuan, Shanxi, China
Shenqiu County People's Hospital
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Zhoukou, Henan, China
Shizong County People's Hospital
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Qujing, Yunnan, China
Song County People's Hospital
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Luoyang, Henan, China
Songming County People's Hospital
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Kunming, Yunnan, China
The First People's Hospital of Qujing
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Qujing, Yunnan, 655000, China
Wannian County People's Hospital
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Shangrao, Jiangxi, China
Wenshui County People's Hospital
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Lüliang, Shanxi, China
Xiage Health Center
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Zhangzhou, Fujian, China
Xiajiang County People's Hospital
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Ji’an, Jiangxi, China
Xianxian Traditional Chinese Medicine Hospital
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Cangzhou, Hebei, China
Xin'an County People's Hospital
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Luoyang, Henan, China
Xingan County People's Hospital
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Ji’an, Jiangxi, China
Xinjian District People's Hospital
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Nanchang, Jiangxi, China
Xiyang County People's Hospital
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Jinzhong, Shanxi, China
Xuanwei First People's Hospital
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Xuanwei, Yunnan, China
Xuanwu Hospital, Capital Medical University
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Beijing, Beijing Municipality, 100053, China
Yangbi County People's Hospital
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Dali, Yunnan, China
Yichuan County People's Hospital
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Luoyang, Henan, China
Yifeng County People's Hospital
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Guangzhou, Guangdong, China
Yiliang First People's Hospital
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Kunming, Yunnan, China
Yima People's Hospital
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Yima, Henan, China
Yimei General Hospital
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Yima, Henan, China
Yongfeng County Traditional Chinese Medicine Hospital
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Ji’an, Jiangxi, China
Yongping County People's Hospital
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Dali, Yunnan, China
Yongtai County Hospital
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Fuzhou, Fujian, China
Yujiang District People's Hospital
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Yingtan, Jiangxi, China
Yunnan Provincial First People's Hospital
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Kunming, Yunnan, China
Yunxiao County Hospital
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Zhangzhou, Fujian, China
Yunxiao County Traditional Chinese Medicine Hospital
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Zhangzhou, Fujian, China
Yuxi Zhongshan Hospital
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Yuxi, Yunnan, China
Zhangpu County Hospital
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Zhangzhou, Fujian, China
Zhangpu County Traditional Chinese Medicine Hospital
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Zhangzhou, Fujian, China
Zhangshu People's Hospital
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Zhangshu, Jiangxi, China
Zhangzhou Changtai District Hospital
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Zhangzhou, Fujian, China
Zhangzhou Fifth Hospital
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Zhangzhou, Fujian, China
Zhangzhou Gulei Port Economic Development Zone First Hospital
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Zhangzhou, Fujian, China
Zhangzhou Hospital
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Zhangzhou, Fujian, China
Zhangzhou Hospital Headquarters (High-Tech Campus)
RECRUITING

Zhangzhou, Fujian, China
Zhangzhou Second Hospital
RECRUITING

Zhangzhou, Fujian, China
Zhao'an County Hospital
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Zhangzhou, Fujian, China
Zhaoping County People's Hospital
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Hezhou, Guangxi, China
Zhoukou Central Hospital
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Zhoukou, Henan, China
Zixi County People's Hospital
RECRUITING

Fuzhou, Jiangxi, China

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