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Stroke breakthrough? drug may clear residual clots after standard treatment

NCT ID NCT05499832

Completed Disease control Sponsor: Insel Gruppe AG, University Hospital Bern Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tested whether giving a clot-dissolving drug called tenecteplase directly into the brain artery can improve blood flow in stroke patients who still have blockages after standard mechanical clot removal. 156 adults with acute ischemic stroke were randomly assigned to receive either the drug or best medical care. The study aims to see if this extra step leads to better reperfusion and less disability at 90 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Tenecteplase (a clot-busting drug given directly into the brain artery)

What this could lead to

If it works, this could offer a way to restore more blood flow in stroke patients who still have blockages after standard clot removal, potentially reducing disability.

What could go wrong

This is a relatively small, early-stage proof-of-concept trial, so results may not be definitive. The drug also carries a risk of bleeding in the brain.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

ischemic stroke large artery stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ISCHEMIC STROKE

Contacts and locations

Locations

  • AZ Sint Jan Brugge AV

    Bruges, 8000, Belgium

  • Amsterdam UMC

    Amsterdam, 1100, Netherlands

  • Asklepios Klinik Altona

    Hamburg, 22763, Germany

  • Centre Hospitalier Universitaire Vaudois

    Lausanne, 1011, Switzerland

  • Centre Hospitalier Universitaire Vaudois (CHUV)

    Lausanne, 1011, Switzerland

  • Christian-Doppler-Klinik Salzburg

    Salzburg, 5020, Austria

  • Clinique CHC MontLégia

    Liège, 4000, Belgium

  • Cliniques universitaires Saint-Luc

    Brussels, 1200, Belgium

  • Helios Klinikum Erfurt

    Erfurt, 99089, Germany

  • Hospital Eagas Moniz

    Lisbon, 1349-019, Portugal

  • Hospital Nelio Mendonca Funchal

    Funchal, 9000-177, Portugal

  • Hospital Santo Antonio

    Porto, 4099-001, Portugal

  • Hospital de Braga

    Braga, 4710-243, Portugal

  • Hôpital universitaires de Bruxelles

    Anderlecht, 1070, Belgium

  • Hôpitaux universitaires de Genève

    Geneva, 1211, Switzerland

  • Johannes Wesling Klinikum Minden

    Minden, 32429, Germany

  • Kantonsspital Aarau

    Aarau, 5001, Switzerland

  • Kantonsspital Aarau

    Aarau, Switzerland

  • Kantonsspital Aarau AG

    Aarau, 5001, Switzerland

  • Kantonsspital Luzern

    Lucerne, 6000, Switzerland

  • Kantonsspital St.Gallen

    Sankt Gallen, 9007, Switzerland

  • Kepler Universitätsklinikum GmbH

    Linz, 4020, Austria

  • Klinikum Bremen-Mitte

    Bremen, 28205, Germany

  • Klinikum der Universität München

    München, 81377, Germany

  • Klinikum rechts der Isar der Technischen Universität München

    München, 81675, Germany

  • LKH-Universitätsklinikum Graz

    Graz, 8036, Austria

  • Leiden UMC

    Leiden, 2300, Netherlands

  • Lisbon Central University Hospital

    Lisbon, 1150-199, Portugal

  • Medizinische Universität Innsbruck

    Innsbruck, 6020, Austria

  • Ospedale Regionale di Lugano

    Lugano, 6900, Switzerland

  • Städtisches Klinikum Sollingen

    Solingen, 42653, Germany

  • UZ Brussel

    Brussels, 1050, Belgium

  • UZ Gasthuisberg Leuven

    Leuven, 3000, Belgium

  • Universitair Ziekenhuis Gent

    Ghent, 9000, Belgium

  • University Hospital Helsinki

    Helsinki, 00029, Finland

  • University Hospital of Lausanne

    Lausanne, Switzerland

  • Universitätsklinikum Augsburg

    Augsburg, 86156, Germany

  • Universitätsklinikum Bonn

    Bonn, 53127, Germany

  • Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden

    Dresden, 01307, Germany

  • Universitätsklinikum Frankfurt

    Frankfurt, 60528, Germany

  • Universitätsklinikum Freiburg

    Freiburg im Breisgau, 79106, Germany

  • Universitätsklinikum Halle (Saale)

    Halle, 06120, Germany

  • Universitätsklinikum Hamburg-Eppendorf

    Hamburg, 20246, Germany

  • Universitätsklinikum Magdeburg A. ö. R.

    Magdeburg, 39120, Germany

  • Universitätsklinikum Münster

    Münster, 48149, Germany

  • Universitätsklinikum Schleswig-Holstein Campus Kiel

    Kiel, 24105, Germany

  • Universitätsklinikum Tübingen

    Tübingen, 72076, Germany

  • Universitätsmedizin Göttingen

    Göttingen, 37075, Germany

  • Universitätsmedizin Mannheim

    Mannheim, 68167, Germany

  • Universitätsspital Basel

    Basel, Switzerland

  • Universitätsspital Bern

    Bern, 3010, Switzerland

  • Universitätsspital Zürich

    Zurich, 8091, Switzerland