STROKE

This study tests whether stroke survivors can safely use a robot called ReHandyBot to exercise their hand at home without a therapist present. Participants first learn how to use the device at a clinic, then take it home to train on their own. The goal is to see if unsupervised h…

This study tests whether combining a gentle electrical brain stimulation (called FNS) with sling-based exercises can help people who have paralysis on one side after a stroke. The trial will enroll 54 adults aged 18-70 who had a stroke within the last 6 months. Participants will …

This trial tests whether giving blood pressure medication inside a mobile stroke unit—a special ambulance with a CT scanner—can improve outcomes for people having a brain bleed. About 706 adults with high blood pressure and a recent stroke will be randomly assigned to either the …

This study tests whether a single daily polypill (combining blood pressure, cholesterol, and anti-clotting drugs) can help recent stroke survivors in Ghana avoid future strokes or heart attacks. About 500 participants will take the polypill or receive usual care for 24 months. Th…

This study tests whether adding 20 minutes of moderate-to-high intensity aerobic exercise before constraint-induced movement therapy helps stroke survivors walk better. Fifty adults who had a stroke at least 6 months ago will take part in a 4-week intensive program, followed by a…

This study tests whether patients with a heart pump (LVAD) can safely stop taking aspirin while continuing warfarin. The goal is to reduce bleeding problems without increasing dangerous clots. About 370 participants will be randomly assigned to receive either aspirin or a placebo…

This pilot study tests whether an active smartwatch that gives real-time feedback, combined with regular nurse coaching, can help people who had a minor stroke or TIA walk more each day. Fifty participants will be randomly assigned to either an active smartwatch or a passive one …

This study tests whether a care model led by rural doctors and supported by telemedicine can reduce strokes, heart failure, and heart-related deaths in adults aged 65 and older who are at high risk of stroke in rural China. About 2,500 participants from 39 village clinics will be…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can improve balance and body control in people who have had a stroke. Twenty-two participants will receive either the stimulation plus balance training or balance training alone. The goal is …

This study tests whether giving a clot-busting drug called tenecteplase before a mechanical clot removal procedure helps people with large ischemic strokes recover better than the procedure alone. About 486 adults with large-vessel occlusion strokes will be randomly assigned to o…

This pilot study will test whether a virtual reality (VR) rehab program done at home can help people recover movement and thinking skills after a stroke or with Parkinson's disease. Sixty participants will either use a VR headset for daily exercises or receive standard rehab. The…

This study tests a program called Moxie that sends weekly mail and a mobile app to help people with chronic heart, kidney, or diabetes conditions manage their health after a hospital stay. The goal is to see if it reduces the chance of going back to the hospital. About 9000 adult…

This study tests a new, drug-free treatment for people having an ischemic stroke (a clot blocking blood flow to the brain). The treatment uses blood pressure cuffs on the arms and inflatable leg sleeves to temporarily reduce blood flow in the limbs, which may trigger the body to …

This study tests whether a virtual reality (VR) home exercise program can help stroke survivors improve arm and hand function. Forty-eight adults who had a stroke at least 3 months ago will either use a VR headset to practice daily activities at home or receive standard therapy. …

This study tests whether cooling the brain with cold saline during clot-removal surgery helps people recover from severe strokes. About 322 adults with large strokes will be randomly assigned to get standard care or standard care plus local brain cooling. The main goal is to see …

This study tests whether cooling the head (using a special cap) during emergency stroke treatment can reduce the amount of brain tissue that dies. About 182 adults having a major stroke and undergoing a clot-removal procedure will be randomly assigned to receive either standard c…

This study tests whether the anti-inflammatory drug ulinastatin can prevent strokes in people having brain tumor removal. About 1,370 patients will receive either ulinastatin or a placebo before and after surgery. The goal is to see if the drug lowers the chance of having a strok…

This study looks at whether using a continuous glucose monitor (CGM) can help manage high blood sugar better than standard finger-prick tests in people with type 2 diabetes who have had a stroke. High blood sugar after a stroke can lead to worse outcomes. The study will involve 8…

This early study tests whether a drug called RK-4 can be safely injected through the skull into the brain of people having a severe stroke. Only 6 participants will receive the injection once a day for 3 days, using a special device. The main goal is to see if the procedure is fe…

This study compares two medical devices used to close a small hole in the heart called a PFO, which can cause strokes. About 1,260 adults who have had a stroke or mini-stroke in the past year will be randomly assigned to receive either the Cocoon PFO Occluder or the Amplatzer PFO…

This study tests a wireless brain-computer interface implanted in the skull to help people who had a stroke regain arm movement. Ten participants will undergo intensive rehabilitation with and without the device. The main goal is to check safety, but researchers will also measure…

This study tests whether a clot-dissolving drug called tenecteplase works better than standard antiplatelet pills for people who have a mild but disabling stroke caused by a large blocked artery. About 864 adults who arrive at the hospital 4.5 to 24 hours after symptoms start wil…

This study will test a combined procedure in 150 people with atrial fibrillation (AFib) who are at risk for stroke. Doctors will use pulse field ablation to correct the heart's rhythm and then close off a small pouch in the heart (the left atrial appendage) to prevent blood clots…

This study tests whether giving a clot-busting drug called tenecteplase directly into the brain artery can help stroke patients who still have blocked blood flow after a standard clot removal procedure. About 344 adults with a major stroke will be randomly assigned to receive eit…

This study compares two blood thinners—apixaban (Eliquis) and warfarin (Coumadin)—in 460 people with advanced heart failure who have a HeartMate 3 heart pump. The goal is to see which drug better prevents strokes, pump clots, and serious bleeding. Participants must have had their…

This study tests whether a low-dose anti-inflammatory drug called colchicine can help people who have had a brain hemorrhage (a type of stroke) recover better and avoid future heart attacks or strokes. About 1,125 adults with signs of artery disease will take either colchicine or…

This study tests a new device called SSMD, which uses non-invasive stimulation to help people with movement problems after stroke, traumatic brain injury, spinal cord injury, or peripheral nerve damage. 120 adults aged 18-80 with moderate to severe arm impairment will receive eit…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This early-stage trial tests whether relaxin, a natural hormone given as a daily injection, can reduce the burden of atrial fibrillation (AF) in 208 veterans who have not responded to standard medications and are scheduled for catheter ablation. The study aims to see if relaxin c…

This pilot study tests whether a rehabilitation program using virtual reality, treadmills, and other technology can help people recover mobility after a stroke. 62 participants will receive the tech-based program, and their progress will be compared to similar patients who had us…

This trial tests a new device called Supernova that removes blood clots from large brain arteries in people having a stroke. The goal is to restore blood flow within 24 hours of symptoms starting. The study will include 3,000 participants and measure how well the device works and…

This study tests whether adding scalp acupuncture to repetitive transcranial magnetic stimulation (rTMS) improves arm movement in stroke survivors. Researchers will compare two groups: one getting rTMS plus standard rehab, and another getting rTMS plus scalp acupuncture and stand…

This study tests a procedure called submaximal balloon angioplasty to improve blood flow in narrowed brain arteries and prevent stroke. It involves 159 people who recently had a mild stroke due to severe artery narrowing (70-99%). The procedure uses a small balloon inflated to a …

This study tests whether adding WhatsApp-based education and counseling to standard care helps stroke patients with type 2 diabetes improve their lifestyle, blood sugar control, and disease knowledge. 84 participants will be split into two groups: one gets routine education, the …

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized lifestyle advice, and long-term support. Researchers will …

This study will test a portable, low-field MRI machine to see how well it detects brain injuries from lack of oxygen or blood flow in children. About 200 kids in intensive care will get both a portable and a standard MRI. The goal is to find out if the portable version is accurat…

This study tests an artificial intelligence system designed to automatically score disability after a stroke using the Modified Rankin Scale. Researchers will compare the AI's scores to those from trained clinicians in 490 stroke patients. The goal is to see if the AI can provide…

This study tests whether using artificial intelligence (AI) along with a smartwatch and a heart monitor patch can find a hidden heart rhythm problem called atrial fibrillation (AF) in people who have had a stroke. AF can cause strokes, but it often comes and goes without symptoms…

This study will check if an artificial intelligence (AI) system can accurately score stroke severity as well as a trained doctor. About 297 adults with a recent stroke will have their speech and facial movements recorded. The AI will analyze these recordings to produce a G-FAST s…

This study aims to see if two new web-based tests (star cancellation and line bisection) can accurately detect visuospatial neglect—a condition where stroke survivors ignore one side of space. About 105 adults who had a stroke will take both digital and traditional paper versions…

This study will check if an artificial intelligence (AI) tool can help less experienced doctors read MRI scans of stroke patients as accurately as a brain scan specialist. About 500 adults who are being evaluated for a stroke will have their MRI results compared. The goal is to s…

This study tests whether the drug cilostazol can prevent recurrent strokes and heart problems in 1100 recent stroke survivors in Ghana. Participants take either cilostazol or a placebo twice daily for 24 months. The goal is to see if this affordable drug, already used in Asia, ca…

This study compares two ways of feeding patients with severe ischemic stroke who have trouble swallowing. The goal is to see if feeding through a tube placed past the stomach (post-pyloric) reduces the chance of developing pneumonia compared to standard stomach feeding. About 174…

This study tests whether an electronic alert in doctors' computers can increase the use of blood thinners to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 2,500 high-risk patients who are not currently on blood thinners will take part. The goa…

This study tests whether a gentle electrical brain stimulation technique called tDCS, given alongside standard rehab, can prevent the development of chronic neuropathic pain after a stroke. Sixty adults who recently had a stroke will receive either real or sham tDCS for 10 sessio…

This study compares apixaban alone versus apixaban plus clopidogrel for 30 days in people who have had a stroke and have both atrial fibrillation and atherosclerosis. About 586 participants will be randomly assigned to one of the two treatments. The goal is to see if the combinat…

This study tests a mobile app called Maya that teaches cognitive behavioral therapy skills to adults who recently had a stroke and feel depressed or anxious. Ten participants will use the app for a few weeks to see if it is easy to use and helps improve their mood. The goal is to…

This study tests whether special attention exercises can improve focus and quality of life in people who have had a stroke. 46 participants will do either attention training or standard rehab for 4 weeks. Researchers will measure changes in attention and daily functioning.

This study tests whether a new, fully immersive virtual reality walking program can help people with traumatic brain injury (TBI) improve their mobility and quality of life. Thirty participants will try two types of VR therapy: one on a treadmill with screens, and another using a…

This study compares three different walking training programs for people recovering from a stroke. Twenty participants will be randomly assigned to moderate-intensity walking, high-intensity walking, or high step-count walking during their inpatient rehab. The goal is to see whic…

This study tests a new type of physical therapy called NICE rehabilitation for people who have had a stroke and have weakness on one side. The therapy uses a computer to show patients how to activate specific muscles, helping them regain arm movement. Researchers will measure cha…

This study tests whether a quick, gentle push on the lower back (called lumbar spinal manipulation) can improve balance and lower fall risk in people who have had a chronic stroke. Fifty-two participants will receive both the real manipulation and a placebo version at different t…

This study looks at whether combining Frenkel exercises (repetitive movements to retrain the brain) with electrical muscle stimulation can improve balance, coordination, and body awareness in people who have had a stroke. About 38 adults aged 50-65 who can walk independently will…

This study will test a comfortable, soft elbow brace that helps bend and straighten the arm, along with a vibrating forearm bracelet that gives touch cues. About 45 people with stroke or Parkinson's disease will try these devices during arm exercises. The goal is to see if the de…

This study tests a robotic device designed to help people with stroke, Parkinson's disease, ALS, or mild cognitive impairment improve their arm and hand function. Thirty adults will receive standard rehabilitation, and half will also use the robot for up to 30 minutes per session…

This study tests a 6-week program where stroke survivors do balance exercises while also performing mental tasks, like naming words or reacting to sounds. The goal is to see if this dual-task training improves stability and mobility better than standard balance exercises alone. 2…

This study tests whether combining augmented reality (AR) balance exercises with a gentle brain stimulation technique (tDCS) can improve balance and movement in people who have had a stroke. About 28 chronic stroke survivors with balance issues will be split into two groups: one …

This study tests if a non-invasive device that stimulates the vagus nerve can improve blood flow in the brain and thinking skills in people who had a stroke 6-12 months ago. Forty participants aged 50-60 with mild cognitive issues will receive the stimulation. Researchers will me…

This study tests whether combining neuromuscular electrical stimulation with upper limb nerve exercises can improve hand grip strength and range of motion in people who have had a stroke. The trial will include 44 adults who had an ischemic stroke at least 3 months ago and have s…

This early study tests a robotic leg brace with smart software that senses how a person walks and adjusts its help in real time. Researchers want to see if this adaptive system improves walking speed and balance in stroke survivors compared to a standard brace. About 20 people, i…

This study looks at whether a gait training program delivered partly at home using a sensor and exercises is feasible and acceptable for people who have had a stroke. Twelve participants in Saudi Arabia will first train in a clinic, then continue at home for four weeks. The goal …

This study looks at whether clenching your jaw can immediately improve walking and movement in people who had a stroke at least six months ago. Thirty participants will either clench their teeth on cotton rolls or keep their jaw relaxed, then take walking and balance tests. The g…

This study tests whether a gentle electrical current applied to the brain (tDCS) combined with hand exercises can improve hand function in people who had a stroke. Fifty-six participants will receive either real or sham tDCS for 20 sessions over four weeks. Researchers will use M…

This study tests a type of physical therapy called PNF (proprioceptive neuromuscular facilitation) for people who have had a stroke. The therapy uses specific leg exercises to improve balance, walking, and daily function. Sixty adults aged 40-80 who can walk with or without help …

This study tests a new way to improve vision loss caused by a stroke. It combines low-intensity focused ultrasound (LIFUS) with virtual reality therapy to stimulate the brain's vision areas. The study will enroll 28 adults who had a stroke 6 to 24 months ago and now have partial …

This study tests whether a virtual home rehabilitation program helps stroke survivors in underserved Texas communities recover better than standard care alone. About 80 adults who recently had a stroke and are returning home will take part. The program uses video sessions to guid…

This study tests a stepped-care model to support relatives of people with acquired brain injury or malignant brain tumor. The model offers basic support to all, with extra help for those who need it, based on screening. Researchers will measure changes in caregiver burden and wel…

This study tests whether a trained volunteer visiting a stroke survivor at home for 8 weeks can improve their ability to cope after hospital discharge. About 840 people who had a stroke and are returning home will either get this extra support or just their usual care. Researcher…

This study tests whether a personalized robotic telerehabilitation program can help people recover arm movement after a stroke. Seventy participants will use a wearable robotic device with virtual reality exercises at home for 4 weeks, supervised remotely. The goal is to see if t…

This early-phase trial aims to see if taking a combination of three common drugs (Telmisartan, Metformin, and Cilostazol) can help chronic stroke survivors gain more movement in their arms and hands during robot-assisted therapy. Fifty adults who had an ischemic stroke at least s…

This study tests a new robot-based therapy designed to improve arm movement and sensation in people who had a stroke more than six months ago. The therapy focuses on helping the brain better process sensory information from the arm. The trial will include 109 participants and com…

This study tests if using augmented reality (AR) games can make rehabilitation therapy more engaging for people with acquired brain injury (like from a stroke or trauma). The goal is to see if this fun approach helps patients stick with their therapy, which could lead to better r…

This study tests whether combining two types of non-invasive brain stimulation (tDCS and TMS) can improve memory, thinking, and movement in people who have had a stroke. Twenty-four participants will receive either real or fake (sham) stimulation daily for one week. Researchers w…

This study compares standard hand-arm training with a version that also includes thinking tasks, like memory or attention exercises, for people recovering from a stroke. Twenty adults aged 40-70 with mild to moderate arm weakness will take part. The goal is to see if combining ph…

This study tests whether corrective exercises paired with rhythmic auditory stimulation (like music or beats) can improve balance, walking, and quality of life in people who have had a stroke. Thirty-two adults aged 40-60 with subacute ischemic stroke will participate. They will …

This study tests whether a gentle, non-invasive electrical brain stimulation (tACS) can improve working memory in people who have memory problems after a stroke. 24 participants will receive either real or fake stimulation for 40 minutes a day for 5 days, alongside cognitive ther…

This study tests a new, non-invasive brain stimulation technique called kTMP to help improve arm and hand function in people who have had a stroke. One hundred adults with chronic stroke-related arm weakness will receive either active or sham stimulation over 18 weeks. The goal i…

This study tests whether intensive music therapy can improve thinking skills like memory, attention, and decision-making in people recovering from a stroke. It will include 36 adults in Malaysia who had a stroke within the last 3 months and have mild to moderate cognitive problem…

This study tests whether a robotic arm exoskeleton, combined with standard physical therapy, can improve arm function in people who had a stroke at least six months ago. Sixty participants will do 15 sessions of robotic training plus 20 minutes of standard rehab. Researchers will…

This study tests whether applying gentle vibration to the bottom of the foot can improve walking speed and balance in people who have had a stroke. Fifty-eight participants will be randomly assigned to receive either real vibration or a placebo (no vibration) for 30 minutes a day…

This study explores whether a non-invasive brain stimulation technique called tDCS can be practically used during routine speech therapy for people who have had a stroke and now have aphasia (trouble speaking or understanding language). Researchers will enroll 30 stroke survivors…

This study tests whether adding immersive virtual reality to stationary cycling, alongside standard physical therapy, can improve walking and balance in people who have had a stroke. Twenty-five adults who are at least six months post-stroke will take part. Researchers will compa…

This study tests if a treatment called extracorporeal shock wave therapy (ESWT) can reduce leg muscle stiffness and improve walking in people who have had a stroke. About 85 adults who had a stroke at least 3 months ago will get either real ESWT or a fake (sham) version, plus sta…

This study looks at whether low-volume high-intensity interval training (HIIT) on a recumbent stepper is safe and doable for people recovering from a stroke in a hospital rehab setting. Fifteen participants will try a 10-minute HIIT session, and researchers will track any side ef…

This study tests a new augmented reality system called MirrARm that uses a camera and screen to create a virtual mirror of a stroke survivor's unaffected arm, making it look like their affected arm is moving. The goal is to see if this high-tech approach improves arm and hand fun…

This study tests whether a home-based music program can improve attention and thinking speed in people who have had a stroke. About 36 Malaysian stroke survivors with mild to moderate cognitive issues will take part. They will use music exercises at home, with help from a caregiv…

This study tests whether a single session of a mental practice technique called PETTLEP-based Action Observation and Motor Imagery (AOMI) can immediately improve arm movement in stroke survivors. Participants will either watch and mentally rehearse a reach-to-grasp task or do a c…

This study tests whether virtual reality exercises can help people who had a stroke within the last three months improve arm and hand function and promote brain healing. Forty adults aged 50-65 will use a VR system alongside standard therapy. The goal is to see if VR can boost re…

This study will test a special moving platform combined with virtual reality to help people with neurological disorders like Parkinson's disease, stroke, ALS, or mild cognitive impairment improve their balance and movement. The platform moves in three directions and adapts exerci…

This study tests whether adding functional electrical stimulation (FES) to task-oriented training helps stroke survivors with arm spasticity regain more movement than training alone. All participants receive Botox for spasticity first. The trial will enroll 40 adults who have had…

This study tests whether a non-invasive treatment called focal vibration therapy can reduce shoulder pain in people who have had a stroke. Sixty chronic stroke survivors with shoulder pain will receive either real vibration or a sham procedure, plus standard rehab. The goal is to…

This study tests whether a robotic arm trainer called BurtVision, which uses augmented reality games, can help chronic stroke survivors improve arm function. Thirty-eight participants will do 18 sessions of either one-arm tasks or a mix of one-arm and two-arm tasks. The goal is t…

This study tests whether a device that sends specific electromagnetic fields can help people who had a stroke more than 6 months ago improve arm function. 25 adults aged 18-80 with moderate arm weakness will use the device in clinic and at home for 3 months. The main goal is to s…

This study tests whether special balance exercises that target the inner ear (vestibular system) can help people who have had a stroke walk better and lower their risk of falling. About 40 adults who had a stroke at least 6 months ago will be assigned to either vestibular trainin…

This study tests whether a special augmented reality training program (AR-FIT) can improve balance and mobility in people who have had a stroke. Researchers will compare AR-FIT to standard therapy in 78 adults aged 40-70 who are at least 3 months post-stroke. The training involve…

This study compares two types of exercise—wobble board and Swiss ball—to see which better improves balance and stability in stroke survivors. About 38 people aged 40-60 who had a stroke more than 6 months ago will participate. The goal is to find a simple, effective way to reduce…

This study tests whether a special suit that delivers mild electrical pulses can quickly reduce muscle stiffness and improve movement in people who have had a stroke. Twenty-six participants will wear the suit for one hour and be compared to a control group receiving minimal stim…

This study looks at whether yoga is a practical and helpful activity for adults who have had a stroke at least three months ago. Forty participants in Nova Scotia will try both virtual and in-person yoga classes twice a week for 90 minutes, plus one recorded session. Researchers …

This study tests whether adding a mild brain stimulation technique (tDCS) to a standard arm therapy (constraint-induced therapy) helps people who had a stroke more than therapy alone. Forty adults with chronic stroke and mild-to-moderate arm weakness will be randomly assigned to …

This study tests a new robotic walking trainer called Rise&Walk InHome that stroke survivors can use at home. Twenty adults who had a stroke 3 months to 5 years ago will either use the device for 30 minutes, 4 times a week plus usual care, or just usual care. The goal is to see i…

This study compares two types of robotic hand therapy for people with chronic stroke and hand weakness. One group uses a robot that moves when the patient's brain waves show they are imagining the movement, while the other group uses a robot that moves automatically. The goal is …

This study tests whether combining two therapies—blood flow restriction training (using a cuff to partially restrict blood flow during exercise) and brain stimulation (rTMS)—can improve arm and hand function in people who have weakness on one side after a stroke. 69 adults will b…

This study tests whether adding an AI-driven virtual reality (VR) program to standard rehabilitation can improve arm movement in people who recently had a stroke. Fifty hospitalized adults with arm weakness will be randomly assigned to either standard rehab alone or standard reha…

This study tests a web-based program that combines physical exercises with brain games for people who had a stroke at least 6 months ago. Researchers want to see if it improves walking, balance, memory, and attention better than usual care. About 52 adults will be randomly assign…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can help people over 70 recover swallowing after a stroke. Twenty participants will receive either active or sham stimulation alongside standard speech therapy for three weeks. Researchers wi…

This study tests whether watching moving bars on a screen through virtual reality glasses can help stroke patients who have spatial neglect — a condition where they ignore one side of their world. Thirty patients aged 50-65 will receive five 4-minute sessions of this visual stimu…

This study compares two therapies—neuromuscular electrical stimulation (NMES) and EMG biofeedback—for treating shoulder subluxation in stroke survivors. Thirty-six participants will receive one of the therapies plus standard physiotherapy for three weeks. The goal is to see which…

This study tests whether augmented reality (AR) can help people who have had a stroke walk with more balanced steps. Twenty adults who had a stroke within the past 6 months will try two types of visual feedback—an avatar and simple bars—while walking in a long hallway. The goal i…

This study tests whether doing simple mental arithmetic before walking can improve gait speed and balance in people who have had a stroke. Seventeen participants will either solve math problems or watch a blank screen before walking. The goal is to see if this 'cognitive priming'…

This study looks at whether raising the head of the bed 30 degrees and playing murottal (Quran recitation) can help stroke patients feel better. Researchers will check blood pressure, pulse, breathing, pain, and vomiting in 112 stroke patients over 3 days. The goal is to find a s…

This study looks at whether custom-made shoes can improve walking quality in people who have had a stroke and still have trouble walking due to muscle tightness and foot dragging. About 58 adults who had a stroke at least 6 months ago will wear adapted shoes and be tested on how …

This study will test whether using an intermittent pneumatic compression device on the leg can improve ankle joint awareness (proprioception) and balance in people who have had a stroke. Fifty-six participants aged 50-65 with moderate balance problems will receive the treatment. …

This study looks at whether adding robotic-assisted walking training to regular physical therapy can improve quality of life, depression, anxiety, and fatigue in people who have had a stroke. Thirty-six adults who had a stroke at least three months ago will receive either robotic…

This study tests whether allowing the pelvis to move freely during robot-assisted walking training helps stroke survivors walk better, improve balance, and reduce fear of falling. About 36 adults who had a stroke at least 6 months ago will receive either pelvic-free or pelvic-res…

This study tests whether adding neuromuscular electrical stimulation (NMES) to standard TENS therapy provides extra relief for shoulder pain after a stroke. Forty adults with hemiplegic shoulder pain will receive either TENS alone or TENS plus NMES, alongside their usual rehab. T…

This study tests whether applying vibration to a specific muscle or the whole arm can reduce spasticity (stiffness) and improve arm control in people who had a stroke 3 to 6 months ago. Fifty-four participants will receive either focal muscle vibration or whole upper limb vibrati…

This study tests whether a chatbot on the Doubao app can reduce depression in people who have had a stroke. Researchers will enroll 240 participants and use the chatbot to provide positive psychological counseling. The main goal is to see if depression scores improve, with qualit…

This study looks at whether adding posture-oriented kinesio taping to standard rehab helps stroke patients improve their balance, coordination, and daily activities. Sixty adults who had a stroke at least one month ago will be randomly assigned to get either the tape plus rehab o…

This study looks at how common vision loss is after a stroke and tests a new rehab method. 300 stroke patients will either get standard rehab or standard rehab plus audio-visual stimulation training using a special device. The goal is to see if this extra training helps improve t…

This study tests a special light therapy (850 nm) on 66 adults who had a stroke within the past year and now have trouble speaking or understanding language (aphasia). The goal is to see if shining this light on the head can improve brain activity and language skills. Participant…

This study tests whether special training of the soleus muscle (a calf muscle) can improve walking and muscle activity in people who have had a stroke. Researchers will measure walking speed, balance, and muscle signals in 40 adults aged 45 to 60. The goal is to see if this targe…

This study compares early task-oriented rehabilitation (practicing daily-life activities) to traditional physiotherapy in 158 adults who had a stroke within the past 48 hours. The goal is to see which approach leads to better motor function and quality of life after 3 months. Par…

This study tests whether Fresnel prism glasses, a low-cost non-invasive tool, can improve visual perception, balance, walking, and daily independence in people recovering from a stroke. Fifty adults who had a stroke on the right side of the brain and have left-side neglect will e…

This study tests whether using a brain-mapping system (neuronavigation) to guide magnetic stimulation (rTMS) helps stroke patients with arm weakness recover better than standard positioning. Thirty adults who had a stroke 2 weeks to 6 months ago will receive 10 sessions over 2 we…

This study tests robotic leg braces (exoskeletons) to help stroke survivors walk more easily. Twenty people who had a stroke at least 6 months ago will try these devices indoors and outdoors. The goal is to see if personalized hip and ankle assistance can improve walking speed, e…

This study compares 3D-printed dynamic splints to traditional ones for improving arm function in people who have had a stroke. One hundred adults with chronic stroke and mild to moderate arm weakness will receive 20 sessions of task-oriented therapy over four weeks, using either …

This study tests a home-based virtual reality system (MUVITY) to help people who had a stroke 3-12 months ago improve their movement and quality of life. 322 participants will either use the VR system with remote therapist guidance or receive standard exercise instructions. The g…

This study tests a personalized self-rehabilitation program designed to help people with chronic stroke improve their ability to perform daily living activities. Researchers will enroll 158 participants who had a stroke more than 6 months ago. The program involves following a tai…

This study tests whether combining robot-assisted walking training with mild electrical stimulation of the spinal cord can help people who have had a stroke and cannot walk. Twenty chronic stroke survivors will receive 24 sessions of this combined therapy. The goal is to see if t…

This study will test a new device that combines a brain-sensing headband with Apple's Vision Pro goggles to help people with ALS, brain injury, or spinal cord injury communicate. Up to 10 participants will use the system for 3-4 months to see how well they can type and control a …

This study tests whether taking probiotics can improve quality of life, daily activities, and anxiety in people who have had a moderate stroke. Researchers will enroll 110 adults aged 18 to 80 who had a stroke within the past 3 months. Participants will take probiotics and be mon…

This study tests whether playing specially designed, AI-powered games can improve thinking skills and arm/hand function in people who have had a stroke. Forty adults aged 45-60 with mild memory or thinking problems after a stroke will use a smartphone app and motion-sensing games…

This study tests whether a structured strength training program (called FaStEx) can reduce fatigue in people who have had a stroke. Sixteen participants will either do strength training twice a week plus home exercise, or just home exercise alone, for eight weeks. The main goal i…

This study tests whether an artificial intelligence system can help therapists set better rehab exercises for a robotic arm trainer used by stroke patients. One hundred adults who had a stroke within the last six months will receive either AI-guided or therapist-guided robotic th…

This study looks at whether combining aromatherapy (using scents) with a gentle brain stimulation technique called transcranial magnetic stimulation can improve sleep in people who have had a stroke and now have trouble sleeping. Six adults aged 24 to 65 who have had a stroke and…

This study tests whether listening to music for 30 minutes a day for 8 weeks can improve attention, language, and quality of life in people with aphasia after a stroke. Researchers will compare music listening to audiobook listening and a control group. The trial involves 45 adul…

This study tests whether a virtual reality device called H'Ability Home can help stroke survivors improve their independence and walking speed better than a standard paper exercise booklet. Forty-four people who have had a first stroke and are about to leave rehab will use the VR…

This study tests whether adding occupation-based bilateral arm training (OBBT) to standard therapy helps stroke survivors improve arm movement and daily activities. 150 participants in inpatient rehab will either get OBBT plus standard care or standard care alone for 6 weeks. The…

This study tests whether shining a low-level laser on the wrist can reduce muscle tightness and improve hand function in 40 stroke survivors aged 45 to 60. Participants will receive either laser therapy plus standard physical therapy or just physical therapy. The goal is to see i…

This study will test whether using smart technologies like brain-computer interfaces and robotic hand therapy can improve recovery in people who recently had a stroke. 200 participants will be split into four groups: three using different high-tech devices and one receiving stand…

This study will use ultrasound to measure the thickness and movement of breathing muscles between the ribs in 65 stroke patients. Researchers will compare the affected and unaffected sides and see how these measurements relate to breathing strength, movement, balance, and quality…

This trial tests an AI tool called MIDI that quickly spots problems in brain MRI scans. The goal is to see if it helps doctors report urgent scans faster, so patients get treatment sooner. Over 100,000 adults will take part across multiple NHS sites in the UK.

This study tests whether having a neurologist consult via video during ambulance transport helps decide the best hospital for suspected stroke patients. About 484 adults with stroke symptoms will be randomly assigned to standard care or standard care plus a telemedicine consultat…

This study will test a device that delivers gentle waist pulls during treadmill walking to improve balance in people who have had a stroke and in older adults with mild balance issues. Fifty participants will undergo nine training sessions over three weeks. The goal is to see if …

This study looks at how stroke survivors with weakness on one side (hemiplegia) perceive internal body signals, like heartbeat, and whether that relates to their balance, touch sensation, and joint position sense. Researchers will assess 60 participants in a single session using …

This study investigates why some chronic stroke survivors with slow walking speed improve after high-intensity interval training (HIIT) while others do not. Participants will undergo 12 weeks of supervised cycling sessions, along with MRI brain scans and walking tests before and …

This study collects a wide range of information from stroke survivors and healthy volunteers, including genetic data, brain scans, electrical brain activity, and thinking and memory tests. The goal is to build a model that can predict which stroke survivors are most likely to dev…

This study tests whether a 6-week program that combines a pedometer with phone or video coaching is practical for people who had a stroke at least 6 months ago. 24 participants will track their steps and set goals with an occupational therapist. The main goal is to see if people …

This study will compare how young adults, older adults, and stroke survivors sense small electrical pulses on their skin. Researchers will measure the smallest changes in pulse frequency, strength, and timing that people can detect. The goal is to gather basic information to impr…

This study tests a simple screening tool to help doctors find muscle stiffness (spasticity) sooner after a stroke. Researchers will track how quickly spasticity is detected and whether the tool helps doctors make faster treatment decisions. About 80 adults who recently had a stro…

This study looks at whether having physical therapy (PT) and occupational therapy (OT) together in one session works as well as having them separately for stroke patients in the hospital. About 567 adults admitted for acute stroke will be randomly assigned to either co-treatment …

This study tests whether a one-week educational campaign called SURA'A can improve how adults recognize stroke symptoms and their intention to seek emergency help. Researchers will enroll 350 adults at primary health centers in Diwaniyah. Participants will receive targeted consul…

This study explores why stroke survivors often feel extreme muscle fatigue. Researchers will use a gentle, non-invasive brain stimulation technique called tACS to temporarily change brain activity in 120 stroke survivors. Participants will do leg exercises until tired while their…

This study looks at how the Achilles tendon behaves during walking in people with spastic paresis, a condition causing muscle stiffness after stroke or spinal cord injury. Researchers will measure tendon stiffness, length, and volume using ultrasound and motion analysis. The goal…

This study looks at whether a treadmill that moves each leg at a different speed can help people who had a stroke walk more evenly and faster. About 30 people who had a stroke within the last 9 months will take part. A physiotherapist will guide them through walking exercises on …

This study will test a new tool called the Stroke Mimics Score (SMS) in 1000 adults who come to the emergency room with stroke-like symptoms. The goal is to see if the SMS can accurately tell the difference between a real stroke and a condition that looks like a stroke but isn't …

This study looks at how well people who have had a stroke can imagine movements (motor imagery) and how that relates to their neglect, arm function, daily activities, and quality of life. Researchers will assess 50 participants using tests and questionnaires. The goal is to bette…

This observational study aims to understand how neuromuscular fatigue develops in stroke survivors compared to healthy individuals. Researchers will measure brain activity (EEG) and muscle activity (EMG) in 120 participants while they perform repeated leg exercises until fatigue.…

This study looks at whether people who had a stroke more than six months ago and cannot move their fingers can regain that ability. Researchers will use brain stimulation and nerve tests to understand who might benefit. Participants will receive electrical muscle stimulation and …

This study tests whether a gentle magnetic pulse called cTBS can improve attention in people who, after a stroke, ignore one side of their surroundings. Sixty adults with right-brain stroke and left-sided neglect will receive real or fake stimulation to the cerebellum or brain's …

This study tests a new way to recruit women into stroke research using easy-to-understand materials like brochures and videos. Researchers will compare this approach to usual recruitment methods with 1,600 participants. The goal is to make stroke studies more inclusive so treatme…

This study will follow up to 12,750 stroke patients in Germany to learn how care is given from the moment symptoms start through hospital treatment, rehab, and long-term recovery. It includes both adults and children with ischemic stroke or brain bleeding. The goal is to collect …

This study tests a driving simulator designed to help people with neurological conditions like stroke, Parkinson's, ALS, or mild cognitive impairment improve their motor and thinking skills. About 60 participants (including healthy volunteers) will use the simulator to see if it …

This study looks at whether a clot-dissolving medicine called tenecteplase is safe and effective for people having a stroke when given more than 4.5 hours after symptoms began. Researchers will follow 3000 patients in China to see how many recover with little or no disability aft…

This study will track 3,000 stroke patients in China who received clot-busting medication more than 4.5 hours after their symptoms began. Researchers want to see if this later treatment is still safe and helps reduce disability. The study is observational, meaning it simply watch…

This study tests whether a one-on-one nursing education session just before a stroke patient goes home can improve how well they follow their medication and care plan. Researchers will enroll 300 stroke survivors who are returning home and randomly assign half to receive the extr…

This study tests whether a program called PEER-HOMEcare is practical and helpful for people recovering from stroke at home. The program involves therapists and family members working together to adapt the home environment and use wearable sensors to track movement. Researchers wi…

This study looks at how well stroke patients can move and how that affects the anxiety, depression, and burden of their caregivers. Researchers will assess 64 stroke patients and their family caregivers using mobility tests and mental health questionnaires. The goal is to underst…

This study will follow 30 adults who have had a stroke and have arm weakness. Researchers will use functional MRI scans at several time points over six months to see how the brain reorganizes itself. The goal is to link different patterns of brain activity to different levels of …

This study looks at how a device called the L300, which uses mild electrical pulses to lift the foot during walking, affects people with stroke, traumatic brain injury, or multiple sclerosis. Researchers will measure walking speed, step length, and balance in 90 adults to see if …

This study will check if certain walking and balance tests are reliable for people who had a stroke at least six months ago. Researchers will use a walking questionnaire, a 400-meter walk test, a falls confidence scale, and a vision test. The goal is to see if these tools can bet…

This study tests whether a smartphone app using AI can help personalize rehabilitation for adults who have had a stroke. Thirty participants will use the app daily for six weeks and keep a diary of their exercises. Researchers want to see if people can use the app and if it adapt…

This study tests a 5-week support program for stroke survivors after they leave the hospital. The goal is to see if the program helps them feel more confident and independent in managing their daily health. Researchers will compare participants who get the program plus usual care…

This study checks if a tool called the Hypertonia Assessment Tool (HAT) can correctly identify different types of muscle tightness in adults who have had a stroke. The tool was already tested in children with cerebral palsy, but not in adults after stroke. Researchers will test 6…

This study looks at how feeling supported by family and friends affects life satisfaction and social activities in adults who have had a stroke. Researchers will compare stroke survivors to healthy adults using surveys. The goal is to understand the role of social support, not to…

This study looks at whether lying flat (0 degrees) or with the head raised (30 degrees or more) after a stroke clot removal procedure helps people recover better. About 2240 adults who had a stroke from a large blood vessel blockage will be randomly assigned to one of the two hea…

This study looks at spit and mouth samples from 120 adults (some who had a stroke, some healthy) to find markers linked to stroke. No treatment is given—just observation. The goal is to learn how oral health and brain health may be connected.

This study looks at how the body's immune and inflammatory systems change in people having a stroke who receive clot-busting drugs or mechanical clot removal. Researchers will take blood samples at several time points over a year to measure inflammation markers. The goal is to se…

This study looks at how the sense of touch and vibration influence hand movement recovery after a stroke. Researchers will test 90 people with recent stroke and some healthy volunteers using hand dexterity tasks with vibrating rings and brain MRI scans. The goal is to see if addi…

This study will compare how well an AI program (Blings) measures speech clarity in 40 adults with speech disorders from stroke or other neurological conditions. Two speech therapists will also rate the same speech samples. The goal is to see if the AI can reliably replace or assi…

This study will look at 2000 adults in the Middle East who have had a stroke to understand how common risk factors like high blood pressure, diabetes, high cholesterol, and smoking are in this group. Researchers want to compare these patterns with what is known from Western count…

This observational study will follow 100 medically fragile adults with conditions like stroke, multiple sclerosis, Parkinson's disease, or certain fractures. The goal is to see if remote check-ins via video calls can reliably spot declines in mobility and thinking, compared to in…

This study reviews past medical records of 462 people who had a stroke caused by branch atheromatous disease (BAD), a blockage in a small, deep brain artery. Researchers want to see if clot-busting drugs (intravenous thrombolysis) work better than antiplatelet medicines (like asp…

This study looks at 150 adults having emergency clot removal for a stroke. Researchers will measure substances in the blood that show blood vessel damage and inflammation. The goal is to learn how these changes relate to recovery, not to test a new treatment.

This study will test a new robotic and virtual reality system called NeglectARm 3D in 15 people who have spatial neglect after a stroke. The system uses a robot arm and VR headset to measure how well patients notice objects in 3D space. Researchers want to see if the device is ea…

This study examines whether two types of blood pressure medications, ACEIs and ARBs, can reduce the chance of developing pneumonia after a stroke. Researchers will analyze medical records from over 13,600 patients with both stroke and high blood pressure. The goal is to see if th…

This study uses robots and eye-tracking to measure how vision and body awareness (proprioception) affect arm movement after a stroke. Researchers will follow 425 stroke survivors for six months to understand how these senses recover and how brain damage relates to recovery. The g…

This study adapts a questionnaire that measures how stroke patients manage their treatment and daily life at home. Researchers will translate the scale into Turkish and test it with 170 adults who have had a stroke. The goal is to make sure the scale is accurate and reliable for …

This study looks at how a caregiver's mood and sleep problems relate to the burden they feel when caring for a stroke patient. It will include 100 stroke patients and their primary caregivers. Caregivers will fill out questionnaires about their sleep, anxiety, depression, and how…

This pilot study tests whether automated, personalized coping messages can help stroke survivors increase their physical activity. Researchers will enroll 50 adults who had a stroke 3 months to 3 years ago and can walk without help. The main goal is to see if the program is pract…

This study tests whether inspiratory (breathing) exercises can increase the thickness of the diaphragm and intercostal muscles in people who have had a stroke. Thirty-five participants will do breathing exercises for 4 weeks, with muscle thickness measured by ultrasound at 2 week…

This study looks at whether waiting until day 3 after a stroke to start physical therapy is better for patients with a persistent blocked artery. Researchers will test if this delayed approach is feasible and if it helps prevent further brain damage. The study involves 50 adults …

This study will look at the genes of 1,000 people in Brazil—half who had a stroke and half who did not—to find genetic differences that may increase stroke risk. Researchers will use whole genome sequencing to analyze DNA and compare it with international data. The goal is to bet…

This study looks at 70 children aged 1 month to 18 years who have neurological disorders like epilepsy, migraine, or stroke. Researchers will use echocardiograms and ECGs to check for hidden heart problems. The goal is to understand if heart issues are common in these children an…

This study looks at whether a non-invasive ultrasound test, done within 24 hours of a stroke, can predict how well patients recover. Researchers will measure blood flow in the brain and compare it to neurological improvement over 72 hours. The study involves 50 adults with acute …

This study looks at how tightness in the ankle muscles (spasticity) after a stroke affects a person's balance, risk of falling, and ability to move around. Researchers will study 68 people who had a stroke at least six months ago, comparing those with mild versus moderate-to-seve…

This study will follow 50 people with brain hemorrhage to see if a feature called the 'spot sign' on CT scans can predict who is at higher risk of death or disability. Researchers will compare these scan findings with standard risk scores. The goal is to improve early identificat…

This study will look at how well 30 stroke survivors can walk backward and how that relates to their leg function, sense of joint position, trunk control, and balance. Participants must be able to walk 10 meters without help and be between 3 days and 24 months post-stroke. Resear…

This study tests a new way to use magnetic stimulation (TMS) to help stroke survivors recover thinking and memory. Instead of a one-size-fits-all approach, researchers will use brain scans to find the exact spot to stimulate for each person. The study will include 10 healthy peop…