STROKE

This study tests a program called Moxie that sends weekly health tips by mail and offers a mobile app to help people manage chronic conditions like heart disease, diabetes, and kidney disease. The goal is to see if it reduces the number of times people are readmitted to the hospi…

This study tests doing two heart procedures at the same time in people with atrial fibrillation (an irregular heartbeat). The first uses energy pulses to fix the heart's electrical signals. The second closes a small pouch in the heart to lower stroke risk and reduce the need for …

This study tests whether a brain implant can help people who had a stroke regain movement in their arm. Ten participants will first do standard rehab, then get the implant and use it to control devices during rehab for six months. The goal is to see if the implant is safe and hel…

This trial tests if cooling the brain with a catheter, combined with reopening blocked arteries, helps people recover from a severe stroke. About 322 adults with a large stroke will be randomly assigned to get the cooling treatment plus standard care, or standard care alone. The …

This study compares two blood thinners—apixaban and warfarin—in people with advanced heart failure who have a HeartMate 3 heart pump. The goal is to see which drug better prevents serious problems like stroke, blood clots, and major bleeding. About 460 adults who have had the pum…

This study tests if a new device (Cocoon PFO Occluder) is as safe and effective as the standard device (Amplatzer) for closing a small hole in the heart called a PFO. The hole can let blood clots travel to the brain, causing strokes. About 1,260 adults who had a stroke or mini-st…

This study tests whether adding a WhatsApp-based education and counseling program to standard care helps stroke patients with type 2 diabetes improve their healthy habits, blood sugar control, and diabetes knowledge. About 84 participants will be split into two groups: one gets r…

This early study tests if a new injection method can safely deliver a drug called RK-4 directly to the brain in people with severe stroke. The drug is given through a small hole in the skull, bypassing the blood-brain barrier. Only 6 people will take part, and the main goal is to…

This study tests whether adding a drug called GM1 to standard clot-removal treatment helps people recover better after a major stroke. About 868 adults with a blocked artery in the front part of the brain will receive either GM1 or a placebo. The goal is to see if more patients c…

This study tests a gentle balloon angioplasty to open narrowed brain arteries in people who recently had a stroke. The goal is to see if the procedure is safe and keeps blood flow improved over time. About 159 participants will be followed for one year to check for stroke or deat…

This study tests whether giving a clot-dissolving drug called tenecteplase directly into the brain artery can help people who still have a blocked vessel after a standard mechanical clot removal for a major stroke. About 344 adults who had a stroke within the last 24 hours will b…

This study tests whether cooling the head, starting as early as possible and continuing until one hour after blood flow is restored, can reduce the amount of brain tissue damaged by a stroke. About 182 adults with a severe type of stroke will be randomly assigned to receive eithe…

This study tests whether a single daily polypill (combining blood pressure, cholesterol, and anti-clotting medications) can reduce the risk of another stroke or heart attack in 680 recent stroke patients in Ghana. Participants will take the polypill or receive usual care for 24 m…

This study tests whether a drug called ulinastatin can lower the risk of stroke after brain tumor removal. About 1,370 people having brain tumor surgery will receive either the drug or a placebo before and after their operation. The goal is to see if the drug's anti-inflammatory …

This study tests whether a low-dose anti-inflammatory drug called colchicine can help people recover better and avoid future heart attacks or strokes after a bleeding stroke (intracerebral hemorrhage). About 1,125 adults with signs of artery disease will receive either colchicine…

This study tests a new care package for adults aged 65 and older who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized guidance, and ongoing support. Researchers will compare this approach to usu…

This study tests a medical device called SSMD that uses gentle stimulation to help people with movement problems caused by stroke, traumatic brain injury, spinal cord injury, or nerve damage. About 120 adults aged 18 to 80 will use the device for 3 weeks to see if it improves arm…

This study tests whether a new MRI-based method (IMPROVE) can better identify which patients with narrowed carotid arteries need surgery or stenting to prevent a future stroke. About 613 adults who recently had a minor stroke or TIA will be randomly assigned to the new method or …

This study tests a community-based exercise program for adults aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, or arthritis. The goal is to see if personalized exercise can improve heart and muscle fitness, mobility, and overall well-b…

This study tests whether adding Relaxin, a natural hormone, to standard care can lower the amount of atrial fibrillation (AF) in 208 Veterans who still have symptoms despite medication and are scheduled for a heart ablation procedure. The goal is to see if Relaxin reduces oxidati…

This study tests whether a clot-busting drug called tenecteplase works better than standard antiplatelet pills for people who have a mild but disabling stroke caused by a large blocked artery. Participants must be treated between 4.5 and 24 hours after symptoms start. The goal is…

This study tests two devices, Supernova and Neutron, that are threaded through blood vessels to remove clots in people having a severe stroke. The goal is to restore blood flow to the brain within 24 hours of symptoms starting. About 3,000 participants will be followed for 90 day…

This study compares two treatments for elderly frail patients with atrial fibrillation (AFib) who are at high risk for both stroke and bleeding. One group gets a heart procedure (catheter ablation) plus a device to close off a part of the heart (left atrial appendage occlusion), …

This study looks at whether a continuous glucose monitor (CGM) can help manage high blood sugar better than standard finger-prick tests in people with type 2 diabetes who have had a stroke. High blood sugar after a stroke can lead to worse outcomes. The trial will involve 82 adul…

This study will check if an AI tool can help resident doctors read stroke MRIs as accurately as expert neuroradiologists. About 500 adults with stroke symptoms will have their MRI scans read by both an AI-assisted resident and a specialist. The goal is to see if AI can speed up a…

This study will see if a small, portable MRI machine can accurately detect brain injuries in children. Researchers will scan 200 children in intensive care and compare the results to standard MRI scans. The goal is to find a faster, easier way to diagnose brain injuries at the be…

This study checks if an artificial intelligence (AI) system can accurately score the G-FAST test, which helps identify strokes. About 297 adults with confirmed stroke will have their G-FAST scores calculated by both the AI and trained doctors. The goal is to see if the AI can pro…

This study looks at whether new web-based tests on a tablet can accurately detect visuospatial neglect—a condition where stroke survivors ignore one side of space. About 105 stroke patients will take both digital and traditional paper-and-pencil tests. The goal is to see if the d…

This study tests whether a gentle brain stimulation technique called tDCS, combined with standard rehabilitation, can prevent the development of chronic pain after a stroke. Researchers will enroll 60 stroke survivors who are at high risk for pain and give half of them real stimu…

This study tests a special therapy and education program for stroke patients in the hospital to help them avoid falls after discharge. About 134 participants will receive either the extra fall-prevention training or standard care. Researchers will track falls for 90 days after le…

This study tests whether the drug cilostazol can prevent another stroke or heart attack in 1,100 stroke survivors in Ghana. Participants take cilostazol or a placebo twice a day for two years. The goal is to find an affordable, effective treatment for stroke prevention in low-res…

This study compares two treatments to prevent another stroke in people who have both atrial fibrillation (an irregular heartbeat) and hardened brain arteries. About 586 participants will receive either the blood thinner apixaban alone or apixaban plus clopidogrel for 30 days. The…

This study tests whether electronic alerts in doctors' computers can increase the use of blood thinners to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 2,500 high-risk patients who are not currently on blood thinners will take part. The goal …

This study tests whether adding a special tape (kinesio taping) to standard rehab helps stroke survivors improve their balance, coordination, and daily activities. Sixty adults who had a stroke at least a month ago will be split into two groups: one gets rehab plus the tape, the …

This study tests whether a treatment called extracorporeal shock wave therapy (ESWT) can reduce leg muscle stiffness and improve walking in people who have had a stroke. About 85 adults who have had a stroke at least 3 months ago and have stiff leg muscles will be randomly assign…

This study looks at whether adding rhythmic music to corrective exercises can improve balance, walking, and quality of life in people who have had a stroke. The researchers will work with 32 adults aged 40 to 60 who have weakness on one side and trouble walking. Participants will…

This study tests a special training program for the soleus muscle (a calf muscle) to see if it can improve walking and muscle activity in people who have had a stroke. The study will include 40 adults aged 45-60 who can walk at least 10 meters with some help. Researchers will mea…

This study explores whether adding a non-invasive brain stimulation technique called tDCS to regular speech therapy is practical and helpful for people who have trouble speaking or understanding language after a recent stroke. Researchers will enroll 30 stroke survivors with apha…

This study tests whether a structured strength training program (FaStEx) can reduce fatigue in people who have had a stroke. Sixteen participants will either do strength training twice a week at a health center plus home activity, or just home activity alone, for eight weeks. The…

This study compares 3D-printed dynamic splints to traditional ones for improving arm function in people who have had a stroke. One hundred adults with chronic stroke and mild to moderate arm weakness will receive 20 sessions of task-oriented therapy over four weeks while wearing …

This study tests whether gentle vibration applied to specific arm muscles or the whole arm can reduce muscle stiffness and improve movement in people who had a stroke. About 54 adults aged 45-60, who had a stroke 3-6 months ago, will receive one of two vibration treatments. The g…

This study tests a new type of training that uses augmented reality (AR) to help stroke survivors improve their balance and ability to move around. Researchers will compare AR training to standard therapy in 78 adults aged 40-70 who had a stroke at least 3 months ago. The goal is…

This study tests whether a home-based music rehabilitation program can improve attention and processing speed in stroke survivors. About 36 adults who had a stroke within the past year and have mild to moderate thinking problems will take part. They will use music exercises at ho…

This study tests a home-based virtual reality system to help people who had a stroke 3 to 12 months ago improve their movement and quality of life. About 322 participants will either get usual rehab instructions or use a special computer program that guides exercises and tracks p…

This study tests a rehabilitation program that uses multiple technologies to help people recover mobility after a stroke. About 62 participants will use the program, and their progress will be compared to similar patients receiving standard care. The goal is to see if the tech-ba…

This study tests a new training method called MINT that uses a muscle-computer interface to help people who have had a stroke walk better. Researchers will enroll 72 adults with leg weakness from a stroke that happened at least 6 months ago. Participants will practice using the d…

This study tests whether adding blood flow restriction training (using a cuff to lightly limit blood flow during exercise) and brain stimulation (rTMS) to standard rehab can help stroke patients with paralysis on one side move better. 69 adults who had a stroke will be split into…

This study tests whether adding scalp acupuncture to standard rehabilitation and brain stimulation (rTMS) can improve arm movement in people who had a stroke. Researchers will use brain imaging to see how the treatments work. The trial plans to enroll 44 adults aged 18-70 who had…

This study tests whether a virtual reality system called VALOR can help stroke survivors improve arm and hand function by doing therapy exercises at home. About 48 adults who had a stroke at least 3 months ago will either use the VR program or receive standard care. The goal is t…

This study tests whether a gentle, non-invasive electrical stimulation to the brain can improve working memory in people who have memory problems after a stroke. Twenty-four participants will receive either real or fake (sham) stimulation for 40 minutes a day for 5 days. Research…

This study tests whether combining Frenkel exercises (repetitive balance and coordination movements) with electrical muscle stimulation can improve balance, coordination, and body awareness in stroke survivors. About 38 adults aged 50-65 who had a stroke and can walk for 10 minut…

This study tests whether a specific type of leg exercise program (called PNF) can improve balance, walking, and daily life in people who have had a stroke. Forty adults who can walk with or without help will be randomly assigned to either the PNF program or standard physical ther…

This study will test a new augmented reality-based mirror therapy system (MirrARm) to help stroke patients recover arm movement and daily function. Thirty adults who had a first stroke 3 to 12 months ago will use the system or standard mirror therapy three times a week for eight …

This study tests a gentle, non-invasive ear stimulation device to help people over 70 improve swallowing after a stroke. Twenty participants will receive either the active device or a sham (inactive) device alongside standard speech therapy for three weeks. Researchers will measu…

This study tests whether a moving visual pattern (optokinetic stimulation) can help stroke patients who have spatial neglect—a condition where they ignore one side of space. Researchers will measure changes in balance, weight shifting, and neglect severity in 30 adults aged 50-65…

This study tests whether adding a gentle brain stimulation technique (tDCS) to a specific arm therapy (Constraint-Induced Therapy) helps people who had a stroke more than the therapy alone. Forty adults who had a stroke at least six months ago and have mild to moderate arm weakne…

This study tests if gentle vibration on the bottom of the foot can improve walking speed and balance in people who have had a stroke. Researchers will measure changes using simple walking tests. The goal is to see if this easy, non-invasive method can help stroke survivors move m…

This study tests a stepped-care program to support relatives of people with serious brain injuries or tumors. The program offers information, screening, and extra help based on each caregiver's needs. 160 relatives will either receive this support or usual care. The goal is to re…

This study tests a new approach to improve vision loss caused by a stroke. It combines low-intensity focused ultrasound (LIFUS) to stimulate brain areas responsible for sight with immersive virtual reality therapy. The study will enroll 28 adults who had a stroke 6 to 24 months a…

This study tests a new virtual reality (VR) walking program for people with traumatic brain injury (TBI) or stroke. Participants will use a VR headset to practice walking in real-world-like settings, while researchers track their steps, distance, and heart rate. The goal is to se…

This study tests whether a device that delivers frequency-tuned electromagnetic fields can safely help improve arm function in people who had a stroke 6 months to 5 years ago. 25 adults aged 18-80 with moderate arm weakness will use the device in clinic and at home for 3 months. …

This study aims to create and test a self-rehabilitation program for people who had a stroke more than 6 months ago. The program is based on everyday activities like dressing or cooking, designed with input from patients. Researchers will see if using this program helps improve m…

This study tests whether allowing the hips to move freely during robot-assisted walking training helps stroke survivors walk better and feel less afraid of falling. About 36 people who had a stroke at least 6 months ago will receive either free-hip or restricted-hip robotic train…

This study looks at whether doing everyday tasks with both arms, like cooking or dressing, can help stroke survivors regain arm movement and participate more in daily life. About 150 adults who had a stroke within the last 6 months will either get standard therapy or standard the…

This study tests whether adding immersive virtual reality to stationary cycling, alongside standard physical therapy, helps people who have had a stroke walk better. Researchers will compare this combined approach to physical therapy alone in 25 adults who are at least 6 months p…

This study tests whether an artificial intelligence system can help therapists create personalized robotic rehab programs for people who had a stroke within the last six months. One hundred participants will either get AI-guided robotic therapy or standard therapist-guided roboti…

This study looks at whether special breathing exercises can make the diaphragm and chest muscles stronger in people who have had a stroke. About 35 adults aged 18–65 will do these exercises for 4 weeks. Researchers will use ultrasound to measure muscle thickness and also check ba…

This study looks at whether a chatbot on Doubao software can help people who feel depressed after a stroke. About 240 participants will use the chatbot to get positive psychological support. The goal is to see if it reduces depression symptoms and improves quality of life. This i…

This study tests whether a virtual reality (VR) rehab program done at home can help people with stroke or Parkinson's disease improve their movement and thinking skills. Sixty adults will either use a VR headset for guided exercises or receive standard rehab. The goal is to see i…

This study looks at whether yoga is a practical and helpful activity for adults who have had a stroke at least three months ago. Researchers will test both online and in-person yoga classes to see if they improve balance, walking, mood, and overall well-being. The study involves …

This study tests whether a non-invasive treatment called focal vibration therapy can reduce shoulder pain in people who have had a stroke. The therapy delivers gentle vibrations to muscles and tendons. Researchers will compare real vibration plus standard rehab to a sham (fake) v…

This study tests whether a 12-week web-based program that combines physical exercises with cognitive training can improve walking, balance, strength, and thinking skills in adults who had a stroke at least 6 months ago. About 52 participants will be randomly assigned to either th…

This study looks at whether raising the head of the bed 30 degrees and playing murottal (Quran recitation) can help stroke patients. It will measure changes in blood pressure, pulse, breathing, pain, and vomiting over 3 days. The study includes 112 Muslim stroke patients with hig…

This study tests a new robot-based therapy designed to improve arm movement and sensation in people who had a stroke more than six months ago. The therapy focuses on helping the brain better process sensory information. About 109 adults with chronic stroke will participate, and t…

This study tests whether a robotic arm training program can help people who had a stroke more than 6 months ago improve their arm movement. Sixty right-handed participants with mild to moderate arm weakness will receive 15 robotic therapy sessions over three weeks, plus standard …

This study tests whether adding thinking tasks to arm and hand exercises helps stroke survivors recover better than standard therapy alone. Twenty adults aged 40-70 with mild to moderate arm weakness will be split into two groups and trained for eight weeks. Researchers will meas…

This study tests a new treatment that uses blood pressure cuffs on the arms and inflatable leg sleeves to improve blood flow to the brain in people having a stroke. The goal is to see if this approach is practical and comfortable for patients while they are being transferred to a…

This study tests whether wobble board or Swiss ball exercises are better at improving balance and stability in people who have had a stroke. About 38 adults aged 40 to 60 who had a stroke more than 6 months ago will participate. The goal is to see which exercise method helps redu…

This study tests whether specially adapted shoes can improve walking quality in people who have had a stroke. It includes 58 adults who have leg stiffness and a tip-toeing walk due to stroke. Participants will wear the adapted shoes for 30 days, and researchers will measure chang…

This study compares early task-oriented rehabilitation (practicing meaningful daily activities) with traditional physiotherapy in 158 adults who had a stroke within the past 48 hours. The goal is to see which approach leads to better motor function and quality of life after 3 mon…

This study tests two types of electrical stimulation to relieve shoulder pain in people who have had a stroke. One group gets standard TENS therapy, while the other gets TENS plus an extra muscle-stimulating current (NMES). The goal is to see which approach better reduces pain, i…

This study tests whether using a GPS-like system (neuronavigation) to guide brain stimulation (rTMS) helps people with arm weakness after a stroke recover better than the standard method. Thirty adults who had a stroke within the last 2 weeks to 6 months will receive 10 sessions …

This study tests a system called BurtVision that combines a robotic arm support with augmented reality games to help people who had a stroke at least 6 months ago. The goal is to see if doing one-arm tasks or both-arm tasks during training leads to better arm use in daily life. A…

This study looks at whether adding robotic leg training to standard physical therapy can help stroke survivors feel better emotionally and physically. About 36 adults who had a stroke at least 3 months ago will take part. They will receive either robot-assisted walking training o…

This study tests whether special balance exercises that target the inner ear (vestibular system) can help people who had a stroke walk better and lower their risk of falling. About 40 adults who had a stroke at least 6 months ago will take part. The goal is to see if these exerci…

This study tests whether shining a low-level laser on the wrist can reduce muscle tightness and improve hand function in people who have had a stroke. Forty stroke patients aged 45 to 60 with mild to moderate wrist stiffness will receive the laser treatment. Researchers will meas…

This study tests whether doing simple mental math (like addition or subtraction) just before walking can help stroke survivors move faster and keep their balance better. Seventeen participants will be asked to walk and perform balance tests after either doing math problems or res…

This study tests whether using a virtual reality headset for home exercises helps stroke survivors become more independent. 44 participants will use the headset for 6 weeks, then compare results to 6 weeks of paper-based exercises. The goal is to see if the headset improves daily…

This study tests whether using an intermittent pneumatic compression device on the leg can improve ankle joint awareness (proprioception) and balance in people who have had a stroke. Fifty-six participants aged 50-65 with moderate balance problems will be measured on how accurate…

This study will test if using smart technologies like interactive rehab tools can improve thinking, daily function, and quality of life for people who recently had a stroke. About 200 participants will be split into four groups: three will use different smart devices, and one wil…

This study tests a wearable electrical stimulation suit (EXOPULSE Mollii) to see if it can quickly reduce muscle stiffness (spasticity) and improve arm, leg, and walking function in people who have had a stroke. 26 participants will wear the suit for one hour and be compared to a…

This study compares three different high-intensity walking training programs to see which one best helps people recovering from a stroke improve their balance, walking speed, and endurance. About 20 adults in inpatient rehabilitation will be randomly assigned to one of the progra…

This study tests whether taking probiotics can improve quality of life, daily activities, and anxiety in people who have had a moderate stroke. Researchers will enroll 110 adults aged 18 to 80 who had a stroke within the last 3 months. Participants will take probiotics and be mon…

This study tests a new virtual reality therapy that combines mirror therapy with focused attention on objects to help stroke survivors improve arm movement. About 54 adults who had a stroke more than six months ago will try one session of this therapy. Researchers will measure ch…

This study tests whether augmented reality (AR) can help people who have had a stroke walk with more balanced steps. Twenty adults who had a stroke within the past 6 months will try two types of visual feedback (an avatar or bars) while walking in an AR environment. The goal is t…

This study tests a new, non-invasive brain stimulation technique called kTMP (kilohertz transcutaneous magnetic perturbations) to help people who have had a stroke and still have arm or hand weakness. Researchers will enroll 100 adults aged 18-80 who have had a stroke causing wea…

This study will test a wearable grasping neuroprosthesis—a device that uses mild electrical stimulation to help open the hand—in two stroke survivors who have trouble extending their fingers. Participants will use the device at home for one year, with regular check-ins to see if …

This study compares two physical therapy approaches—pelvic proprioceptive neuromuscular facilitation and multiplanar trunk training—to see which better improves balance and functional mobility in people who have had a stroke. The trial will involve 48 adults who had a stroke at l…

This study tests whether adding artificial intelligence-driven virtual reality (VR) therapy to standard rehabilitation helps stroke patients regain arm movement better than standard therapy alone. Fifty adults hospitalized after a recent stroke will be randomly assigned to receiv…

This study tests whether adding gentle electrical stimulation to arm exercises helps stroke survivors with muscle tightness regain better use of their affected arm. About 40 adults who have had a stroke and received Botox for arm spasticity will be randomly assigned to either sta…

This study looks at whether a single session of a mental practice technique (watching and imagining a reaching motion) can immediately improve arm movement smoothness in stroke survivors. About 28 adults aged 40-80 who have had a stroke and have some arm movement will participate…

This study compares two treatments—neuromuscular electrical stimulation (NMES) and EMG biofeedback—for shoulder subluxation (partial dislocation) in people who have had a stroke. About 36 adults who had a stroke more than 3 months ago will receive one of the two therapies. The go…

This study looks at whether lying flat (0 degrees) or sitting up (30 degrees or more) after a clot-removal procedure helps stroke survivors recover better. About 2240 adults who had a stroke from a large blocked artery will be randomly assigned to one of two head positions. The g…

This study tests robotic leg braces (exoskeletons) to help stroke survivors walk more easily. About 20 people who had a stroke at least 6 months ago will try these devices indoors and outdoors. The goal is to see if personalized hip and ankle assistance improves walking speed, en…

This study tests whether virtual reality (VR) exercises can help people who had a stroke within the last three months improve arm and hand function and promote brain healing. Forty adults aged 50–65 will use a VR system to practice arm movements. Researchers will measure changes …

This small study will test whether combining aromatherapy with transcranial magnetic stimulation (a non-invasive brain stimulation technique) can improve sleep in stroke patients who have insomnia. Six participants will receive the treatment and have their sleep monitored. The go…

This study tests whether listening to music for 30 minutes each day can improve attention, language, and quality of life in people with aphasia after a stroke. 45 adults who had a stroke at least 6 months ago will be assigned to listen to music, an audiobook, or no intervention f…

This study tests whether combining robot-assisted walking training with a mild spinal cord stimulation can help people who had a stroke and still cannot walk. Twenty adults who had a stroke at least six months ago will try this therapy for 24 sessions. The goal is to see if it is…

This study tests whether combining mirror therapy with a soft robotic glove can improve hand function in people who have had a stroke and have weakness on one side. About 104 adults aged 18-70 with moderate hand impairment will be randomly assigned to different therapy groups. Th…

This study tests whether a home-based stroke rehabilitation program called PEER-HOMEcare is practical and helpful for adults recovering from a stroke. The program involves therapists and family members creating a stimulating home environment to support recovery. About 45 particip…

This study looks at whether a short, intense workout on a special stepper machine is safe and doable for people recovering from a stroke in the hospital. Researchers will check for side effects, how many people can finish the 10-minute session, and if participants enjoy it. The g…

This study tests whether Fresnel prism glasses, a low-cost non-invasive tool, can improve vision, balance, walking, and daily living skills in people recovering from a stroke. Fifty adults who had a stroke on the right side of the brain and have left-sided neglect will either get…

This study tests whether using augmented reality (AR) games can make rehabilitation therapy more engaging for people with acquired brain injury (from stroke or trauma). The goal is to see if this approach improves how often patients practice their exercises and their overall reco…

This study tests a new, low-cost robotic walking device that stroke survivors can use at home. Twenty adults who had a stroke 3 months to 5 years ago will either use the device plus usual care or just usual care for 12 weeks. The goal is to see if the device is safe, easy to use,…

This study looks at two ways to help stroke patients who have a breathing tube in their neck (tracheostomy) get it removed safely. One method uses a special valve, and the other caps the tube. The goal is to see which method works better and faster. About 120 stroke patients will…

This study is testing whether a special training program using artificial intelligence and video games can help people recover thinking skills and arm function after a stroke. Researchers will enroll 40 adults who had a stroke at least 6 months ago and have mild thinking difficul…

This study will test a new device that combines a brain-computer interface with Apple Vision Pro to help people with ALS, traumatic brain injury, spinal cord injury, or stroke communicate. Up to 10 participants will use the system for 3-4 months to see how well it works and how e…

This study looks at 150 adults who have had a severe stroke and are undergoing a procedure to remove a blood clot from their brain. Researchers will measure specific substances in the blood that show how the inner lining of blood vessels is damaged and how the body's immune syste…

This study will follow 500 adults who recently had a stroke to see if handedness affects how well they regain arm movement. Researchers will measure arm function shortly after the stroke and again at 6 months. The goal is to understand if left-handed people recover better due to …

This study looks at a specific type of stroke called Branch Atheromatous Disease (BAD), where a small artery deep in the brain gets blocked. Researchers will compare three treatments: a clot-busting drug (IV thrombolysis), one antiplatelet drug, or two antiplatelet drugs. They wi…

This study looks at how tightness in the ankle muscles (plantar flexor spasticity) affects balance, the risk of falling, and daily movement in people who have had a stroke. Researchers will measure spasticity, balance, and mobility in 68 adults aged 45-60 who had a stroke at leas…

This study tests whether a robotic hand that moves when you imagine moving it (using brain signals) works better than a robot that moves automatically. Twenty adults with chronic stroke and hand weakness will try one of the two therapies. The goal is to see which approach helps t…

This study tests whether a smartphone app can help adults who have had a stroke with their rehabilitation. The app uses AI to create personalized exercises. Researchers want to see if people can use the app and if it adapts to their needs. 30 participants will use the app daily f…

This study looks at how the immune system and inflammation change in people having a stroke who receive clot-busting treatment or mechanical clot removal. Researchers will measure inflammatory markers in the blood at several time points over a year. The goal is to see if these ma…

This study checks if a tool called the Hypertonia Assessment Tool (HAT) works well for adults who have had a stroke. The HAT helps doctors tell apart different types of muscle tightness, like spasticity and rigidity. Researchers will test 60 stroke survivors to see if the tool gi…

This study checks if an artificial intelligence (AI) system can accurately score how well stroke patients recover, compared to the standard method done by trained doctors. About 490 stroke patients will have their recovery scored by both the AI and a human expert to see if the AI…

This study follows 30 adults who had a stroke causing severe arm weakness. Researchers will use brain scans (fMRI) to see how the brain changes and rewires over time. The goal is to better understand why some people recover more movement than others, which could help design bette…

This study tests a new way to improve thinking problems after a stroke. Researchers will use brain scans to find the exact spot to stimulate with magnetic pulses for each person. 25 people (10 healthy, 15 stroke survivors with memory or attention issues) will receive both real an…

This study uses robots and eye-tracking to measure how vision and body awareness (proprioception) affect arm movement after a stroke. Researchers will follow 425 stroke survivors for six months to see how these senses recover and how they relate to brain changes seen on MRI. The …

This study looks at whether a special ultrasound of the brain, called transcranial Doppler, can help predict how well people will recover after a stroke. Researchers will measure blood flow in the brain within 24 hours of a stroke and then check patients' recovery 72 hours later.…

This study looks at whether certain walking and balance tests are reliable for people who have had a stroke at least six months ago. Researchers will test 30 participants using a walking questionnaire, a 400-meter walk, a falls confidence scale, and a vision test. The goal is to …

This study is testing a community-based program designed to reduce loneliness and social isolation in adults aged 60 and older living in rural Ecuador. The program includes group activities, peer support, and home coaching over 12 months. Researchers will measure changes in socia…

This study tests a support program to help stroke survivors better manage their health after leaving the hospital. About 140 adults who have had a stroke will take part. Half will get usual care, and the other half will also attend 5 weekly sessions to learn self-management skill…

This study looks at how the mood and sleep problems of caregivers for stroke patients relate to the burden they feel. Researchers will ask 100 caregivers and their patients (ages 18-80) to fill out questionnaires about sleep, anxiety, depression, and caregiving strain. The goal i…

This study tests whether a one-week educational campaign at primary health centers can help adults recognize stroke symptoms and call for emergency help faster. Researchers will enroll 350 adults without prior stroke history to measure changes in awareness and intended actions. T…

This study will test a new robotic and virtual reality system called NeglectARm 3D in 15 people who have had a stroke and experience spatial neglect (difficulty paying attention to one side of space). The goal is to see if the system is easy to use and reliable compared to standa…

This study tests whether a gentle, non-invasive brain stimulation method called cTBS can improve attention in adults who have trouble noticing things on one side after a stroke. Sixty participants will receive either real or fake stimulation while researchers track their eye move…

This study tests whether an artificial intelligence (AI) system can help doctors find hidden atrial fibrillation (an irregular heartbeat) in people who have had a stroke. About 400 participants will be randomly assigned to either AI-guided monitoring with wearable devices or stan…

This study will follow about 12,750 adults and children who have had a stroke (either from a clot or bleeding in the brain). Researchers will collect information on their care from the moment they arrive at the hospital through recovery and long-term follow-up. The goal is to lea…

This study looks at two common ways to help people recover after a stroke: working with one therapist at a time, or with two therapists together. About 567 stroke patients will be randomly assigned to one approach. The goal is to see which method leads to better movement and dail…

This study tests a new way to recruit women into stroke research. Women often have worse outcomes after a stroke but are left out of studies. The ORDER toolkit uses easy-to-understand materials made with patients. Researchers will compare this approach to usual recruitment and tr…

This study will follow 90 people who recently had a stroke and have hand weakness. Researchers will test hand movement and sensation, including how vibration affects dexterity, and use MRI scans to look at brain structure. The goal is to see if adding vibration tests can better p…

This study aims to translate and test a questionnaire that measures how stroke patients experience their treatment and manage their own care. Researchers will enroll 170 adults aged 18-80 who have had a stroke and been home for at least one month. The goal is to ensure the Turkis…

This study looks at how well stroke survivors can imagine movements (motor imagery) and how that relates to their arm function, daily living skills, and quality of life. Researchers will assess 50 people who had a stroke in the right side of the brain within the past 1 to 6 month…

This study will look at 2,000 adults in the Middle East who have had a stroke to find out how common risk factors like high blood pressure, diabetes, high cholesterol, and smoking are. Researchers want to understand these risks better so they can help prevent strokes in the futur…

This pilot study tests whether an automated system that gives personalized coping tips can help stroke survivors become more physically active. Fifty adults who had a stroke 3 months to 3 years ago will use the system for 3 months. The main goal is to see if the approach is feasi…

This study looks at how well people who have had a stroke can walk backward and how that connects to their leg function, sense of joint position, trunk control, and balance. About 30 adults aged 30-85 who had a stroke within the last 3 days to 24 months will be tested using simpl…

This study looks at whether a special nurse consultation before stroke patients go home helps them follow their medication and care plan. About 300 adults who had a mild stroke and are returning home will take part. Half will get the nurse talk, and the other half will get usual …

This study looks at how a device that sends small electrical signals to leg muscles affects walking in people with stroke, traumatic brain injury, or multiple sclerosis. Researchers will measure walking speed, step length, and balance in 90 adults who have trouble lifting their f…

This study looks at how much social support stroke survivors feel they have and whether that affects their life satisfaction and ability to take part in social activities. Researchers will compare 81 adults who had a stroke at least 3 months ago with healthy volunteers. The goal …

This study will observe 3,000 stroke patients in China who receive clot-busting medication more than 4.5 hours after their symptoms began. The goal is to see if this late treatment is safe and helps reduce disability. Participants will be followed for 90 days to measure their rec…

This study will check if certain substances in saliva and the mouth are linked to stroke. Researchers will compare 120 adults who had a stroke with healthy volunteers. No treatments or drugs are given—the goal is simply to learn more about possible connections between oral health…

This study looks at how genes might influence stroke risk in Brazil's mixed-heritage population. Researchers will compare the DNA of 1000 people—some who had a stroke and some who didn't—to find genetic differences. The goal is to better understand stroke and pave the way for per…

This study looks at how the Achilles tendon behaves during walking in people with spastic paresis (muscle stiffness) caused by stroke or spinal cord injury. Researchers will measure tendon stiffness, length, and volume, as well as calf muscle strength, using ultrasound and force …

This study aims to understand if specific markers on brain scans can better predict which patients with brain hemorrhage face higher risks of death or disability. Researchers will compare scan findings with existing prediction methods in 50 participants. The goal is to improve ri…

This study looks at whether waiting until day 3 after a stroke to start physical therapy is better for patients with persistent artery blockages. Researchers will test if delayed mobilization is safe and helps reduce brain damage and improve recovery. The study involves 50 adults…

This study looks at how well stroke survivors can move around and how that impacts the mental health of the people caring for them. Researchers will measure the patient's mobility and the caregiver's anxiety, depression, and overall burden. The goal is to understand this connecti…

This study looks at whether giving the clot-busting drug tenecteplase more than 4.5 hours after a stroke starts is safe and helpful. Researchers will follow 3,000 adults in China who receive this late treatment in regular hospital care. The goal is to see if patients have less di…

The purpose of this study is to explore whether intensive music therapy can help improve cognitive functions like memory, attention, and decision-making skills in stroke patients who are undergoing rehabilitation. This is a feasibility study, meaning it's also designed to see ho…