STROKE

This study aims to see if an intensive, therapist-led rehabilitation program delivered at home is as effective for recovery as traditional inpatient rehab after a stroke. Researchers will observe about 500 patients who choose either the home-based program or a rehab facility, com…

This study is testing if a small device implanted in the heart (called WATCHMAN FLX) is a safe and effective alternative to taking daily blood-thinning pills for people with atrial fibrillation (AFib). The goal is to prevent strokes without the long-term risk of serious bleeding …

This study is testing a year-long healthy lifestyle program specifically designed for people who have had a stroke. The program focuses on better eating and increased physical activity to help participants lose weight. Researchers want to see if this approach improves weight, fit…

This early-phase study aimed to test whether donated umbilical cord blood could help adults recover from stroke or spinal cord injury. The cord blood contains cells and healing factors that might repair damaged brain and nerve tissue. The trial was withdrawn before any participan…

This study is testing a telehealth program to help people control their blood pressure after a stroke. The program includes video check-ups with a care team and home blood pressure monitoring. Researchers want to see if this approach improves health and reduces racial disparities…

This study aims to find the best short-term medication to prevent blood clots from forming on a heart device. The device is implanted to help prevent strokes in people with atrial fibrillation. Researchers are comparing a newer type of blood thinner (DOAC) to standard aspirin-lik…

This study is testing whether immersive virtual reality (imVR) can help stroke survivors in Ethiopia regain arm and hand function. Researchers are working with 18 participants to see if this technology is practical and acceptable in their local setting. The goal is to gather info…

This study is testing whether a new blood thinner called abelacimab causes fewer bleeding problems than the standard medication rivaroxaban in people with atrial fibrillation. It involved 1,287 patients aged 55+ who need long-term blood thinners to prevent strokes. The main goal …

This study is testing a new heart implant device designed to prevent strokes in people with a common heart rhythm problem called atrial fibrillation. The device seals off a small pouch in the heart where blood clots often form. Researchers will compare this new device to two alre…

This large observational study aims to understand the long-term effectiveness of treatments that control a fast, irregular heart rhythm called atrial tachycardia. It will track 1,000 patients who have received this type of treatment, monitoring them for serious health events like…

This study is testing whether a specific type of exercise, called High-Intensity Interval Training (HIIT), can improve heart health and recovery in people who recently had a stroke. It will compare HIIT to gentle stretching exercises in 50 patients within their first 3 months aft…

This study aimed to test whether a soft, wearable robotic suit could help people who have had a stroke improve their walking. The idea was to use the suit during high-intensity training sessions to help patients walk with better quality and for longer distances. Researchers wante…

This study is testing a new rehabilitation program called REAP in Bangladesh, where many stroke survivors don't get enough help. The program teaches practical skills, adapts daily tasks, and helps people return to meaningful activities. Researchers want to see if this approach wo…

This is a special, single-patient treatment program for an 84-year-old man who had a stroke and hasn't improved with standard care. Doctors are testing whether six infusions of his own specially processed stem cells, given about a month apart, are safe and might help his recovery…

This study is observing how well a small, plug-like device works in real-world patients to prevent strokes. The device is implanted in the heart to seal off an area where dangerous blood clots can form in people with a common heart rhythm problem. Researchers are following over 6…

This study is testing whether a combination of electrical stimulation and robot-assisted training can help people who have had a stroke regain movement and function in their weakened arm and hand. It involves 65 participants in Hong Kong who are at least 6 months past their strok…

This study is monitoring a small heart implant device after it has been approved for use. The device is designed to close a small, common hole in the heart (called a PFO) in people who have had a stroke with no other clear cause. Researchers are tracking 300 patients in Japan to …

This large study aims to find the best medication to prevent future strokes in people who have recently had a stroke caused by a severely narrowed brain artery. It will compare newer blood-thinning drugs (rivaroxaban and ticagrelor) to the standard drug (clopidogrel) in over 1,60…

This study is testing whether online group doctor visits help people better manage type 2 diabetes and related heart conditions. Researchers are comparing virtual group visits to regular individual care for 720 patients across Chicago health systems. The goal is to see if this ap…

This study is testing if applying an over-the-counter numbing cream to a person's stronger arm muscles while they exercise their weaker, paralyzed muscles can help improve strength and sensation. It involves 30 adults with a specific type of spinal cord injury. The goal is to see…

This study is testing whether keeping blood pressure higher during emergency stroke surgery leads to better recovery. Researchers are comparing two different blood pressure targets in 550 stroke patients undergoing clot removal. The goal is to determine if higher pressure improve…

This study is testing if giving a cholesterol-lowering drug called evolocumab very early after a heart attack, along with standard care, is better than standard care alone at preventing future serious heart problems. It involves over 6,000 adults who were hospitalized for a heart…

This study is testing a new robotic device designed to help people who have had a stroke walk better. The machine guides leg movements and provides sound cues to support repetitive walking practice, which is a key part of stroke rehabilitation. Researchers will measure if using t…

This study is testing whether adding a high-protein drink to strength training helps stroke survivors rebuild lost muscle and improve their mobility better than strength training alone. Researchers are comparing two groups of stroke survivors over 12 weeks: one does strength trai…

This study is testing whether exercise training, brain training, or a combination of both can help older adults who have had a stroke and also have high blood pressure or diabetes. Over 400 participants in several Chinese cities will be assigned to one of four groups for a year t…

This study aims to find the safest and most effective medication plan after implanting a device that helps prevent strokes in people with atrial fibrillation. It compares three different drug approaches: aspirin alone, a low-dose blood thinner, or a two-drug combination. The goal…

This large study is testing if treating sleep apnea soon after a stroke can help people recover better and prevent future health crises. Over 3,000 recent stroke patients are being randomly assigned to either receive standard care or standard care plus treatment for their sleep a…

This study compares a new heart implant device to two existing devices for closing a small hole in the heart called a PFO. The goal is to see if the new device works as well at closing the hole and preventing future strokes in people who've already had one unexplained stroke. Res…

This study is testing a new statewide system to improve emergency care for the most severe strokes. It aims to get patients who need a specialized clot-removal procedure to the right hospital faster by coordinating ambulance crews and hospital resources through a central communic…

This large study is testing whether a small device implanted in the heart is as good as, or better than, daily blood thinner pills for preventing strokes in people with a common heart rhythm problem called atrial fibrillation. About 2,650 participants at high risk for stroke were…

This large, long-term study is analyzing health records to see if effectively treating both obstructive sleep apnea and high blood pressure can prevent serious heart problems or death. It will follow 10,000 patients to compare outcomes between those who use their sleep apnea mach…

This study is checking if a small heart implant called the AMPLATZER PFO Occluder is safe and works well to prevent another stroke in people who have already had one. It involves about 1,200 adults in the US and Canada who have a small hole in their heart (a PFO). Doctors will fo…

This study is testing whether a safe, non-invasive brain stimulation technique can help people who have had a stroke improve their ability to move their affected arm and hand. Participants receive either real or placebo stimulation along with standard physical therapy. The goal i…

This study aims to see if a new computer analysis of standard brain artery scans can better predict who is at high risk for another stroke. It will involve 400 adults who have already had a minor stroke or warning sign and have a narrowed brain artery. Researchers will analyze th…

This study is testing a new ultrasound-based scoring system to better predict which people with plaque buildup in their neck arteries are most likely to have a stroke or heart attack. Researchers will look back at past patient data and also follow new patients to see if this meth…

This study is testing a new type of CT scanner designed to be used right in the operating room. The goal is to see if it can tell the difference between a stroke caused by a clot and one caused by bleeding as accurately as the standard hospital scanner. If it works, doctors could…

This study aims to create a more accurate and consistent method for detecting tiny blood clots (microemboli) in the brain, which are strong predictors of future strokes. Experts will analyze ultrasound recordings from 850 patients to develop a computer model that helps classify t…

This study is testing a new handheld device designed to measure muscle stiffness (spasticity) in the arms of people who have had a stroke. The goal is to see if this tool provides a more precise and reliable measurement than the standard tests doctors currently use. The study inv…

This study aims to prevent strokes in young Nigerian adults with sickle cell anemia, where strokes affect 10% of patients. Researchers will measure how common strokes and silent brain injuries are in 250 participants aged 16-25, then test whether regular blood transfusions or a d…

This study is testing a smart wearable airbag system designed to prevent injuries from falls. The device uses sensors and computer algorithms to detect when someone is falling and quickly inflates an airbag to cushion the impact, aiming to reduce hip fractures. Researchers are te…

This study is testing whether sending reminder letters from a local pharmacist can encourage more adults in Alberta, Canada, to get their flu shot or travel vaccines. Researchers will mail one of two different informational letters to 20,000 pharmacy customers to see which messag…

This study is testing whether a structured, music-based training method can help people who had a stroke more than six months ago. 80 participants will be randomly assigned to either receive the training twice a week for 12 weeks or be in a control group. Researchers will measure…

This study is testing if adding extra sensory feedback—like touch and feel—to a common stroke rehab technique called mirror therapy helps people recover arm movement better. Researchers will compare this enhanced therapy to standard mirror therapy in 84 stroke survivors. They wil…

This study is testing whether using a robotic exoskeleton to help move a patient's arm is better than standard physical therapy for improving arm function after a recent stroke. It involves 70 adults who have had a stroke within the last 90 days and have moderate to severe arm we…

This study is testing whether adding a special interactive screen to standard therapy helps people recover from a common stroke side effect called 'left neglect.' Left neglect makes it hard for patients to notice or respond to things on their left side. Researchers in Argentina w…

This study is testing a new nurse-led bedside care program designed to help stroke survivors. It aims to improve their core (trunk) control, breathing function, and overall quality of life during their hospital rehabilitation. The program also helps train nurses in this specializ…

This study is testing whether adding electrical muscle stimulation to standard physical therapy helps people recover leg movement after a stroke. Twenty-five participants who had a stroke at least six months ago will receive either standard therapy or therapy plus electrical stim…

This study aimed to test whether a virtual reality (VR) system could help people recover arm movement after a stroke or other brain injury. The VR system used games based on everyday tasks like cooking or shopping. Eligible participants would have used the VR system twice a week …

This study is testing two different training programs for adults who have had a stroke and are still experiencing mild-to-moderate problems with memory, attention, or thinking speed. Both programs use a web-based computer 'game' designed to improve how quickly the brain processes…

This study tests a telehealth program designed to support family members caring for someone who has had a stroke. The program helps caregivers build skills to manage the survivor's needs while also looking after their own physical and mental health. Over 330 participants will wor…

This study is testing whether fun virtual reality games in a shared online world (the metaverse) can help people with brain injuries or diseases like stroke, MS, or Parkinson's. The games focus on cooking, puzzles, and social activities to improve memory, attention, and thinking …

This study is testing whether a small, wearable vibration device is practical and comfortable for stroke survivors to use at home. The goal is to see if gentle vibrations can improve hand sensation and movement for people living with long-term effects of a stroke. The research is…

This study is testing if a type of massage therapy can help people who have had a stroke. It aims to see if the massage reduces muscle stiffness and leads to better walking and balance. The study will involve 34 adults who had a stroke 6 months to 2 years ago.

This study is testing a new device designed to help people walk better after a stroke. The device is a motorized leg brace combined with gentle electrical muscle stimulation. Researchers are working with a small group of Veterans to see if this 'smart' system can make walking saf…

This small pilot study is exploring a new approach to help people who have trouble swallowing after a stroke. Researchers are testing whether adding fine hand motor skill exercises to standard speech therapy can improve swallowing recovery. The study involves 30 participants over…

This study is testing whether a new support program is practical and acceptable for people recovering from a stroke. Participants will wear a Fitbit to track steps and have weekly video chats with a therapist for six weeks. The main goal is to see if people can stick with the pro…

This study is testing if adding gentle electrical stimulation to standard swallowing exercises helps people who have trouble swallowing after a recent stroke. It will compare different types of stimulation to see which one best improves swallowing safety and muscle function. The …

This VA study is testing whether magnetic stimulation of the brain can help reduce the severe fatigue many people experience after a stroke. The trial will involve 60 stroke survivors who have been dealing with fatigue for over 6 months. Researchers will use a technique called re…

This study is testing an 8-week online program designed to help couples cope with the emotional challenges after a stroke. It involves 400 participants (200 couples) where one partner had a stroke 3 months to 3 years ago. The program teaches skills like communication, gratitude, …

This study is testing new rehabilitation exercises that combine physical and mental tasks, like walking while solving a puzzle, to help people with stroke, multiple sclerosis, Parkinson's disease, or long COVID. The goal is to see if these 'dual-task' exercises, often supported b…

This study is testing whether a special therapy combining robotic arm training with gentle tendon vibrations can help improve arm and hand movement in people who had a stroke more than six months ago. Researchers think the vibrations might help the brain relearn how to control mu…

This study is testing whether a telehealth program called 'teleABLE' can help people who've had a stroke in the past year sit less and improve their quality of life. Participants will try either the teleABLE program or a general health education program, both delivered remotely. …

This study is testing whether a new at-home video rehabilitation program, supported by community health workers, is a practical way to help people recover after a stroke. It involves 11 stroke survivors in the Rio Grande Valley of Texas. The main goal is to see if this home-based…

This study is testing whether combining a gentle, non-invasive brain stimulation technique with core stability exercises can help people recover trunk control, balance, and daily function after a stroke. It will involve 60 participants aged 55-70 who have had a single stroke with…

This Mayo Clinic study is testing whether a home-based brain stimulation device, combined with daily activities, can help people recover thinking and language skills after a stroke, brain tumor, or neurodegenerative disease. The research aims to see if this approach is practical …

This study is testing whether a mild, painless electrical current applied to the scalp (called tDCS) can boost the benefits of speech therapy for people who have trouble speaking after a stroke. About 200 participants will receive either real or fake stimulation during therapy se…

This study is testing a new automated device designed to help people who have had a stroke improve their walking. The device provides support at the waist and uses sound cues to guide patients as they practice walking on the ground. Researchers will measure changes in walking spe…

This study aims to understand how stroke and age-related muscle loss (sarcopenia) affect leg strength and muscle oxygen use. Researchers will measure the maximum force people can produce at their hip, knee, and ankle joints, while also monitoring oxygen levels in their leg muscle…

This study aims to understand why people with chronic kidney disease (CKD) often develop memory loss and thinking problems. Researchers are following 600 people, with and without CKD, for up to five years, tracking their cognitive function and taking brain scans. The goal is to i…

This study is observing over 19,000 older adults who previously participated in an aspirin trial to see if there are any delayed health effects years after stopping the medication. Researchers are primarily watching for long-term impacts on cancer, dementia, heart disease, and ph…

This study aims to find a biological marker (like a specific pattern on a brain scan) that can predict which stroke survivors with spatial neglect will respond best to therapy. Researchers are enrolling 45 people who had a stroke 1-8 months ago to track their recovery over 6 mont…

This study aims to create a practical toolkit to help future stroke rehabilitation clinical trials run better. Researchers are working directly with stroke survivors, their families, and healthcare staff to design it together. The goal is to make it easier for everyone to follow …

This study aims to understand how the speed at which a person processes information affects their movement, balance, walking, and quality of life after a stroke. Researchers will measure thinking speed and physical abilities in 100 people who have had a first-time ischemic stroke…

This study aims to understand why some people with diabetes develop serious heart and kidney problems while others do not. Researchers are collecting detailed health information and blood samples from 48,000 people with diabetes in Hong Kong to look for genetic and other biologic…

This study aims to understand the non-medical reasons—like transportation problems or lack of awareness—that delay stroke patients from reaching the hospital quickly. Researchers will use patient surveys, mapping technology, and brain scan data to train a computer model to identi…

This study aims to better understand how heart and lung function relate to future heart problems in Chinese patients with various heart conditions. Researchers will follow 200,000 participants for five years, using exercise tests to measure heart and lung performance. The goal is…

This research project is analyzing thousands of existing medical studies to understand a puzzling problem: why do some patients with high blood pressure who are on medication and have their blood pressure under control still die from heart attacks, strokes, or kidney failure? The…

This study tested if a special board game could help older adults who recently had a stroke think about and communicate their preferences for future medical treatments. Researchers enrolled 72 participants to see if playing the game changed their treatment choices, reduced feelin…

This early study aims to understand how a soft robotic 'exosuit' helps people walk after a stroke. Researchers will measure how 22 stroke survivors walk with and without the suit to see if it can improve their movement. The goal is to learn how to best match the suit's assistance…

This study is creating a large international database to collect information from about 8,000 people who had a stroke and later developed seizures (post-stroke epilepsy). Researchers will analyze this data to better understand how seizures affect recovery and to build a tool that…

This study aims to understand how common heart disease and its risk factors are among adults in Port-au-Prince, Haiti. Researchers will follow about 3,000 people for several years, tracking their health, lifestyle, and diet. The goal is to gather information to help plan better h…

This study aims to understand how common seizures are after someone has a stroke and to find clues that might predict who is at risk. Researchers are looking at brain scans, blood tests, and brain wave patterns (EEG) from over 600 stroke patients. The goal is to discover new biol…

This study aims to understand how people who have had a stroke use healthcare services in the years after their initial recovery. Researchers will analyze medical records from thousands of patients and conduct surveys and interviews with about 240 stroke survivors. The goal is to…

This is a long-term observational study that aims to understand how heart and blood vessel diseases develop in people before they show symptoms. It follows over 6,400 healthy men and women from four different ethnic backgrounds, aged 45-84, using regular scans and tests over many…

This study is testing a new online platform called CONNECT, designed to help more women, Black, and Latino adults join heart disease research. The program sends educational text messages about heart health and clinical trials for one year and helps connect interested people to on…

This study aims to understand if shoulder pain affects balance in people who have had a stroke and developed weakness on one side of their body (hemiplegia). Researchers will compare 100 stroke survivors, split into two groups: those with shoulder pain and those without. They wil…

This study aims to understand how the brain functions and recovers after a stroke by observing 1000 patients over time. Researchers will collect brain scans, electrical brain activity readings, blood samples, and track physical recovery. The goal is to identify patterns that can …

This study aims to understand how nerve reflexes affect walking problems in stroke survivors with stiff-knee gait. Researchers will measure leg muscle responses to gentle electrical stimulation in 60 participants, both with and without stroke. The goal is to learn if specific ref…

This study aims to understand if a child's genes affect their risk of developing epilepsy later in life after having seizures as a newborn. Researchers are following about 300 children and their parents to look for genetic clues. The goal is to combine genetic information with br…

This study aims to use advanced technology to precisely measure balance and walking problems in people with stroke, Parkinson's disease, or multiple sclerosis. Researchers will use a special balance platform and motion-capture sensors to track 60 participants during a rehab progr…

This study aims to understand how a stroke affects brain activity and heart function. Researchers will measure brain waves and heart rhythms in 45 people—some who have had a stroke and some who are healthy. The goal is to find patterns that could help guide future research and pa…

This study aims to understand how applying focused ultrasound to a specific part of the brain (the cerebellum) affects brain activity and thinking skills in healthy people. Researchers will compare real ultrasound to a fake (sham) treatment while volunteers perform memory and thi…

This study is testing whether personalized educational videos can help people who had a stroke 1-10 years ago better understand their condition. Researchers are comparing the video approach to standard education to see if it improves knowledge about stroke causes, risk factors, a…

This study aims to understand stroke risk in adults with sickle cell disease, as current prevention guidelines are based on children's data. Researchers will follow 102 adults for several years, tracking who experiences strokes and monitoring brain health. The data collected will…

This study aimed to understand how powerful cholesterol-lowering drugs (PCSK9 inhibitors) affect inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation in participants already on standard statin medicat…

This study aims to find out if simple physical tests can help doctors figure out what's causing a person's balance problems. Researchers are comparing how healthy people and people with conditions like stroke, spine issues, or vision problems perform on balance and muscle tests. …

This study aims to better understand how muscles change and become stiff (spastic) after a stroke. Researchers will use ultrasound scans to look at the arm and leg muscles of 80 stroke survivors. The goal is to gather detailed information that could help improve future assessment…