STROKE

This large phase 3 trial tests whether newer blood thinner combinations (ticagrelor plus aspirin or rivaroxaban plus aspirin) are better than the standard clopidogrel plus aspirin at preventing stroke, brain bleeding, or death from blood vessel disease. Over 1,600 participants wi…

This study tests an implanted electrical stimulator to improve walking in people who have had a stroke. Six participants will first be screened, then receive the implant and use it at home. Researchers will compare advanced control settings to a simple trigger to see which works …

This study tests whether people with atrial fibrillation who receive a WATCHMAN FLX Pro device can safely take just one blood thinner or aspirin instead of the usual two-drug plan. About 1,857 participants are being followed for six months to compare rates of death, stroke, major…

This study tests a wireless device that stimulates the vagus nerve during rehabilitation exercises to help people who have had a stroke recover arm and hand function. The approach, called targeted plasticity therapy, aims to enhance the brain's ability to rewire itself. The trial…

This large study is testing whether a device called WATCHMAN FLX, which closes off a small pouch in the heart, can be a safe and effective alternative to daily blood thinners (NOACs) for preventing strokes in people with non-valvular atrial fibrillation. The trial involves 3,000 …

This study tests a special balloon catheter coated with the drug paclitaxel to treat narrowed or re-narrowed brain arteries. The balloon is inflated inside the artery to open it and release the drug, which may help prevent the artery from closing again. The trial includes 281 adu…

This study tests a new device (Laminar) to close the left atrial appendage, a small pouch in the heart, in 1500 people with non-valvular atrial fibrillation. The goal is to see if it is safer and works better than existing devices to reduce the risk of stroke and blood clots. Par…

This study tests a new device called the Occlutech Flex II PFO Occluder, which is used to close a small hole in the heart (PFO) that can cause strokes. The trial involves 450 people who have had a stroke with no clear cause and a PFO. Researchers want to see if the new device wor…

This pilot study tests whether a blend of in-person therapy and home-based digital rehab (video calls and apps) works as well as traditional full in-person rehab for people recovering from stroke, brain bleeding, or head injury. Thirty participants will each try both approaches i…

This study tests whether repeatedly inflating a blood pressure cuff on the arm (called remote ischemic conditioning) can improve thinking and memory in people who have had a stroke or have small vessel brain disease. Eighty participants will receive the treatment twice daily for …

This study compares two approaches—short-term anticoagulation (stronger blood thinners) versus antiplatelet therapy (milder blood thinners)—to prevent clots on a device placed in the heart's left atrial appendage. The trial involves 510 adults who have had this procedure. The goa…

This study looks at a device called the AMPLATZER PFO Occluder, which is implanted to close a hole in the heart (PFO) in people who have had a stroke. Over 1,200 participants are being followed for up to 5 years to see if the device prevents another stroke and is safe. The goal i…

This study tests if a device that closes a small pouch in the heart (left atrial appendage) is safer and more effective than long-term blood thinners for preventing strokes in people with atrial fibrillation. About 2,650 participants with AFib and high stroke risk are randomly as…

This study tests whether using a CPAP machine to treat sleep apnea shortly after an ischemic stroke can reduce the risk of another stroke, heart attack, or death within 6 months. It also looks at whether CPAP improves overall recovery and brain function. Over 3,000 participants a…

This study tests whether regular exercise and cognitive training, alone or together, can improve physical and mental function in adults aged 60+ who have had a stroke and also have high blood pressure or diabetes. Over 400 participants from five Chinese cities will take part in 1…

This study tests whether drinking a protein beverage after leg-strengthening exercises helps stroke survivors rebuild muscle better than exercise alone. About 93 people who had a stroke more than 3 months ago will take part. Researchers will measure changes in thigh muscle size, …

This study tests whether carefully managing blood pressure during a clot-removal procedure for stroke can improve patient recovery. About 550 people having emergency clot retrieval will have their systolic blood pressure kept within a specific target range. Researchers will then …

This study tests whether high-intensity interval training (HIIT) on a stationary bike can improve heart rate variability—a key sign of recovery—in people who recently had a stroke. Fifty patients within three months of their first stroke will either do HIIT or low-intensity group…

This study tests a smart wearable airbag that detects when someone is falling and inflates to cushion the impact. It is designed for people at high risk of falling, such as those with stroke, Parkinson's disease, or a leg amputation. The goal is to see if the device can reduce fa…

This study is checking how well a device called the GORE® CARDIOFORM Septal Occluder works and how safe it is for people who have had a stroke caused by a hole in the heart (PFO). Researchers will follow 300 patients in Japan for 12 months after the device is implanted. The goal …

This phase 2 study compares abelacimab, a new biologic blood thinner, to the standard drug rivaroxaban in 1,287 people with atrial fibrillation who are at moderate-to-high risk of stroke. The goal is to see if abelacimab causes fewer major or clinically relevant bleeding events w…

This study compares getting skilled nursing care at home versus in a traditional facility for people who need rehabilitation after a hospital stay. About 300 adults will be randomly assigned to either recover at home with a technology-supported care team or go to a skilled nursin…

This study tests whether virtual group visits—where patients meet online for diabetes education, support, and goal setting—can improve blood sugar control in people with type 2 diabetes who also have heart-related conditions. About 720 adults from participating clinics will take …

This study tests a healthy lifestyle program designed for people who have had a stroke. The program focuses on weight loss and increasing physical activity. Researchers will track 65 participants for 12 months to see if the program helps them achieve and maintain a healthier weig…

This study tests whether giving evolocumab, a powerful cholesterol-lowering drug, very early during a heart attack hospital stay can reduce the chance of another heart attack, stroke, or death. About 6,000 adults hospitalized for a heart attack are randomly assigned to receive ev…

This study observes over 600 people with atrial fibrillation who received the Amulet device to close a part of the heart called the left atrial appendage. The goal is to see how well the device prevents strokes and bleeding in everyday medical practice. Participants are followed …

This study tested a stem cell treatment (HB-adMSCs) in one 84-year-old man who had a stroke. The cells were taken from his own fat tissue and given through an IV every 28 days for 6 doses. The goal was to see if it was safe and could help him recover. The study is no longer avail…

This study planned to test whether donated umbilical cord blood could help adults with stroke or spinal cord injury. However, the trial was withdrawn before enrolling any participants, so no data or results are available.

This study tests whether a video-based telehealth program, including an iPad and remote blood pressure monitoring, can help stroke survivors better control their blood pressure after leaving the hospital. The program also aims to reduce racial disparities in post-stroke care. Abo…

This study tests whether a water-resistant, wireless ECG patch worn for 7 days can detect more cases of hidden atrial fibrillation (a heart rhythm problem that raises stroke risk) than the usual 24-hour Holter monitor. Researchers will enroll 320 adults who recently had a stroke …

This study tests whether a music-inspired community campaign, called Music4Health, can help lower blood pressure and improve stroke awareness among 1,412 youth (ages 14-24) and their caregivers (ages 40+) in Nigeria. Participants will take part in listening sessions and activitie…

This study tests whether following the MIND diet for 2 to 3 years can slow cognitive decline and reduce dementia risk in people aged 55 and older who have had an ischemic stroke. The MIND diet combines elements of the Mediterranean and DASH diets, with extra emphasis on leafy gre…

This study tests whether sending a short, encouraging letter from a pharmacist can motivate more adults to get their flu and travel vaccines. Researchers will track vaccination rates and also check if vaccinated people have fewer strokes in the following six months. About 20,000 …

This study explores whether joining a weekly reading group can improve reading comprehension and communication confidence in adults with aphasia, a language disorder often caused by stroke. Participants read a book at home and then discuss it in a 90-minute group session each wee…

This study tests whether adding home-based telerehabilitation via WhatsApp video calls to standard outpatient therapy improves hand function in people who had a stroke 1-6 months ago. Forty-eight participants will be split into two groups: one gets standard therapy plus daily 30-…

This study compares two types of hand and arm therapy for people who had a stroke 3 to 6 months ago. One therapy involves restraining the good arm to force use of the affected arm, while the other focuses on using both arms together. Both groups also receive standard physical the…

This study compares two physical therapy approaches—Rood's techniques (using touch, stretch, and ice) and PNF patterns (diagonal movements)—to improve arm and hand function in people who recently had a stroke. 28 adults aged 40-60 with a first-time stroke will receive one of the …

This study tests whether a special arm brace that reads muscle signals can help stroke survivors with severe arm weakness recover better during early rehabilitation. Three veterans who had a stroke within the past 6 months will use the device alongside standard therapy. The goal …

This study compares two rehabilitation methods—somatosensory stimulation (using touch) and task-based mirror therapy (using a mirror to trick the brain)—to see which better improves arm and hand function in stroke survivors. About 24 adults who had a stroke 1 to 6 months ago will…

This study tests whether combining gentle touch stimulation with nerve exercises can improve arm movement and feeling in people who had a stroke 6-12 months ago. 53 adults aged 45-65 with lasting arm weakness and sensory loss are participating. The goal is to see if this therapy …

This study compares two types of exercise programs to see which one better improves balance and leg movement in people who have had a stroke. The study includes 52 adults aged 45 to 65 who had a stroke 6 to 10 months ago and have mild to moderate leg weakness. Participants will d…

This study tests a small, wearable device that gives gentle vibrations to the wrist of stroke survivors. The goal is to see if it's practical for people to use at home and whether it might improve hand movement and feeling. Only 20 people who had a stroke at least six months ago …

This study tests whether exercising both legs together (bilateral training) or just the affected leg (unilateral training) with visual feedback from mirrors and floor targets works better for improving balance, walking, and sensation in people who had a stroke. Fifty participants…

This study tests a remote program called teleABLE that helps people who had a stroke within the past year reduce their sitting time. Participants either get 12 behavioral coaching sessions or 6 health education sessions. The goal is to see if the program improves quality of life …

This study planned to test whether an augmented reality (AR) app called Reia could help stroke survivors with arm weakness do rehab exercises at home. Participants would have used an AR headset for daily 30-minute sessions over 8 weeks, with weekly video check-ins from a therapis…

This study tests whether using a mild electrical stimulation device on the belly muscles, along with core exercises, can improve balance and muscle thickness in people who have had a stroke. Only 2 participants are enrolled, so it is a very early test. The goal is to see if this …

This study tests whether combining neuromuscular electrical stimulation (NEMS) with voluntary muscle contraction can improve ankle function in people with chronic stroke. Twenty-five participants will either receive conventional physiotherapy or NEMS plus active dorsiflexion exer…

This study tests a new therapy that uses moving sounds to help stroke survivors with spatial neglect — a condition where they ignore one side of space. 18 participants will either get standard rehab or standard rehab plus dynamic auditory cueing for 4 weeks. The goal is to see if…

This study tests whether acceptance and commitment therapy (ACT), delivered via online video calls, can help stroke survivors adjust emotionally. Five adults who had a stroke over three months ago will attend weekly 90-minute group sessions for eight weeks. Researchers will track…

This study tests a device called GaitBetter that combines treadmill walking with cognitive training (like thinking tasks) to help stroke survivors improve their walking and balance. About 76 people who had a stroke (either within 8 weeks or more than 6 months ago) will use the de…

This study tests whether vibrating the tendons, combined with robotic arm training, can improve arm and hand movement in people who had a stroke at least 6 months ago. 40 participants will receive the therapy, and researchers will measure changes in motor function and body awaren…

This study tests a nurse-led program to help stroke survivors improve trunk control, posture, and breathing. About 130 stable stroke patients in rehabilitation wards will take part. The program focuses on bedside exercises guided by nurses to build core strength and independence.

This study tests whether a mobile app, supported by a community health worker, can help stroke survivors recover at home. Eleven uninsured stroke survivors in Texas will use the app for personalized exercises and receive support. The goal is to see if this approach improves mobil…

This study tests whether adding an interactive screen (MYRO) to standard therapy helps people who had a stroke and have trouble paying attention to one side of their world (left neglect). About 30 adults with a recent stroke will be split into two groups: one gets standard therap…

This study tests whether a mild electrical current applied to the brain (tDCS) during speech therapy can improve language recovery in people with aphasia after a stroke. Two hundred adults with language problems from left-brain damage will receive either real or fake stimulation …

This early study tests a simple idea: temporarily numbing non-paralyzed arm muscles with an over-the-counter lidocaine cream while exercising paralyzed muscles. Researchers hope this will improve strength, function, and sensation in people with spinal cord injury. About 30 adults…

This study planned to test whether a soft robotic exosuit worn on the ankle could help stroke survivors walk better. Participants would have done high-intensity gait training with or without the exosuit. The goal was to see if the suit could improve walking distance and speed. Ho…

This study tests a set of virtual reality exergames in the Metaverse to help people with neurological conditions like multiple sclerosis, Parkinson's disease, stroke, and traumatic brain injury improve their cognitive skills. 25 participants will try games like virtual cooking an…

This study tests whether adding a mild electrical stimulation to the neck muscles can help people who recently had a stroke and now have trouble swallowing. Forty participants will receive either standard swallowing therapy or therapy plus electrical stimulation. The goal is to s…

This study compares two approaches to help stroke survivors with mild to moderate thinking problems. Both groups use a web-based computer game that trains how quickly they process information. One group also gets in-lab training on everyday activities, while the other focuses on …

This study tests a telehealth program called TASK III for people caring for a family member after a stroke. The program includes a resource guide and eight weekly calls from a nurse to help caregivers build skills and manage their own health. Researchers will measure changes in c…

This study tests whether adding touch and sound feedback to standard mirror therapy can improve arm function in stroke survivors with arm weakness. Eighty-four participants will be split into three groups: one gets the enhanced therapy, one gets digital mirror feedback only, and …

This study tests a new automated walking trainer that uses sensors and cues to help stroke survivors improve their gait. The device aims to make repetitive walking practice easier and more effective than traditional therapist-led training. The study will enroll 60 adult stroke su…

This study tests whether a virtual reality (VR) headset can help people who have had a stroke improve arm movement. Eighteen adults in Ethiopia will use the VR system for nine sessions over three weeks. Researchers will measure how usable and comfortable the system is, and also c…

This study tests whether combining a gentle brain-stimulation technique (transcranial direct current stimulation) with core stability exercises can improve trunk control, balance, and walking ability in people who have had a stroke. Sixty participants aged 55 and older who had a …

This study tests a new program called PA-ChatS that helps people increase physical activity in the first 6 weeks after a stroke. Participants wear a Fitbit to track steps and have weekly phone meetings with an occupational therapist for 6 weeks. The study includes 25 stroke survi…

This study tests a new device that helps stroke survivors improve their walking. The device uses mechanical support and sound cues to guide natural walking patterns. The trial will enroll 40 adults who have had a stroke and can walk without help. The goal is to see if the device …

This study tests a remotely delivered 8-week program called ReStoreD for couples where one partner has had a stroke. The program teaches goal-setting, communication, and positive thinking skills to reduce anxiety and depression. Researchers will enroll 400 couples to see if the p…

This study tests whether a home-based brain stimulation device (tDCS) combined with activity therapy can help improve cognitive and language problems in people with stroke, brain tumors, or neurodegenerative conditions like Parkinson's or Alzheimer's. Fifty-five participants will…

This study tests whether using a robotic exoskeleton for arm exercises helps people who had a stroke recover arm function better than standard therapy. About 70 adults with moderate to severe arm weakness within 90 days of their first stroke will participate. The goal is to see i…

This pilot study aimed to test whether a virtual reality (VR) cooking simulation could improve arm movement and daily function in people with acquired brain injury. Participants would have used VR to practice reaching, grabbing, and stirring motions. However, the trial was withdr…

This pilot study explores whether fine motor hand exercises can help improve swallowing problems in older adults who recently had a stroke. Researchers believe that activating the hand and mouth areas of the brain together may boost recovery. The study involves 30 participants an…

This study tests a device called the Neuromechanical Gait Assist (NMGA) that combines a powered knee brace with muscle stimulation to help people who have difficulty walking after a stroke. Five veterans with leg weakness and a stiff-legged gait will use the device in a lab while…

This study tests whether the Ronnie Gardiner Method (RGM) — a program that combines coordinated movements, spoken cue words, and rhythmic music — can improve balance and quality of life in people who had a stroke more than six months ago. Eighty adults will be randomly assigned t…

This study tests whether a newer, less invasive heart-lung machine (MiECC) reduces brain swelling and stroke risk compared to the standard machine used during open heart surgery. Researchers will measure optic nerve sheath diameter (a marker of brain pressure) and track strokes o…

This study follows 350 people who survived a brain bleed (intracerebral hemorrhage) and were part of earlier trials. Researchers will test memory, thinking, and movement skills over time, and collect blood samples to look for signs of ongoing inflammation. The goal is to see if s…

This study combines data from over 2,500 people with treated and controlled high blood pressure to understand why some still die from heart attacks, strokes, or kidney failure. Researchers are looking beyond blood pressure numbers to find other factors that might predict these fa…

This study looks at whether having a rehabilitation doctor see stroke patients early in their hospital stay can shorten how long they stay and reduce the chance of coming back. Researchers are tracking 3,000 stroke patients to see if this coordinated care approach improves recove…

This study collects movement data from 250 people with stroke, Parkinson's disease, or leg amputations using wearable sensors and video. The goal is to build an online database that researchers can use to study how people move and recover. No treatments are being tested—this is p…

This study looks at whether blood flow restriction training (using tight bands on the legs during exercise) can improve walking in people who had a stroke at least 6 months ago. 40 participants, aged 40-65 with mild leg stiffness, will do resistance exercises with or without bloo…

Most stroke survivors struggle to stay physically active after rehab, raising their risk of another stroke. This study works with survivors, carers, and staff to design a program that supports long-term activity. 34 participants will help shape and test the program.

This study looks at whether using wearable devices and a mobile app can help people who have had a stroke improve their walking and daily activity during a 6-week home exercise program. About 120 adults who can walk but have some difficulty will be split into two groups: one usin…

This study will observe 200,000 Chinese adults with heart disease to see how their heart and lung function changes over 5 years. Participants will take a special exercise test to measure their fitness. Researchers hope to find better ways to predict future heart problems like hea…

This study follows over 2,400 adults in Korea who have had their first stroke. Researchers will track their recovery, daily activities, and quality of life for 10 years. The goal is to learn what factors help or hinder long-term recovery after a stroke.

This study reviewed the medical records of 2500 people who received hyperbaric oxygen therapy (HBOT) for conditions like traumatic brain injury, stroke, fibromyalgia, or age-related decline. Researchers compared computerized thinking and memory tests taken before and after treatm…

This study looks at whether a coordinated emergency system, like those used for trauma, can help more severe stroke patients get a clot removal procedure called mechanical thrombectomy. Researchers will compare data from before and after the system is put in place across Alabama.…

This study looks at how activating muscles changes the way people who have had a stroke perceive touch. Researchers will measure the smallest electrical pulse that can be felt on the fingertips while muscles are at rest and while they are active. The goal is to better understand …

This study tests whether watching storytelling videos can help African American and Black patients with atrial fibrillation (an irregular heartbeat) start and continue taking blood thinners to prevent strokes. About 80 adults who are not currently on blood thinners but have a hig…

This study looks at whether a computer-guided breathing machine (ventilator) protocol can help patients with serious brain injuries. The goal is to use low air volumes to protect the lungs while keeping carbon dioxide levels normal to protect the brain. About 728 adults on ventil…

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…

This study follows 1,000 stroke survivors and their caregivers to understand how social factors and discrimination affect recovery. Researchers will survey participants over time to measure outcomes like quality of life and caregiver strain. The goal is to identify why some group…

This study examines whether a common gene variation (CYP2C19) influences the long-term risk of serious heart and blood vessel events, such as heart attacks, strokes, and limb problems, in people with vascular disease. Researchers will analyze genetic and health data from 13,000 p…

This study tests a new handheld tool that measures muscle stiffness (spasticity) in people who have had a stroke. Researchers want to see if the device gives the same or better results than standard clinical tests. The study involves 40 adults aged 18-75 with a history of stroke …

This study brings together stroke survivors, families, staff, and researchers to co-design a toolkit that helps everyone follow trial protocols in inpatient stroke rehabilitation. The goal is to reduce missed sessions and errors, making trial results more trustworthy. About 38 pe…

This study looks at whether short bursts of breathing air with less oxygen (like at high altitude) can improve arm and hand function in people who had a stroke at least six months ago. Twenty participants will undergo 15 cycles of one-minute low-oxygen breathing followed by norma…

This study is building a large biobank of health information and blood samples from 48,000 people with diabetes in Hong Kong. Researchers will analyze genetic and other markers to find better ways to predict serious complications like kidney failure, heart disease, and stroke. Th…

This study measures how much force leg muscles can produce and how they use oxygen in people with stroke or sarcopenia (age-related muscle loss). Researchers will test hip, knee, and ankle strength at different angles and speeds. The goal is to gather data that could help design …

This study looks at whether stroke patients who do high-intensity rehab at home recover just as well as those who go to a rehab facility. Researchers will follow 500 patients who choose home rehab and compare their progress to patients who went to inpatient rehab. The goal is to …

This study looks at balance and movement problems in people with stroke, Parkinson's disease, or multiple sclerosis. Researchers will use special devices to measure how well participants can keep their balance and walk. The goal is to learn more about these issues so that rehabil…

This study follows 1000 adults who have had a stroke to better understand how the brain recovers. Researchers use brain scans, electrical signals, and physical tests to find patterns linked to recovery. The goal is to improve predictions and treatments for stroke survivors.

This study follows 102 adults with sickle cell disease to track how often silent and overt strokes occur. Participants undergo regular MRI scans and neurological exams over 3.5 years. The goal is to gather data that could lead to the first stroke prevention trials specifically fo…

This study follows about 3,000 adults in Port-au-Prince, Haiti, to learn how common heart disease risk factors like high blood pressure, diabetes, and smoking are, and how they lead to heart attacks, strokes, and other heart problems. Researchers will track participants for about…

This study looks at whether custom-made videos can help people who had a stroke 1 to 10 years ago better understand their condition and feel more satisfied with their care. About 100 participants will use a video app and answer surveys after 7 and 90 days. The goal is to see if t…

This study looks at whether common balance tests can tell doctors why a person is having trouble with balance. Researchers will test 330 people, including healthy volunteers and patients with stroke, vision problems, inner ear issues, spine problems, or spinal cord damage. The go…

This study aims to develop a new way to measure arm and hand function in people with brain disorders like stroke or Parkinson's disease. Researchers will use a smart board and smart glove to collect movement data and compare it with standard tests. The goal is to create a more pr…

This study followed 602 people who had a stroke to see how many later had seizures. Researchers looked at blood tests, brain scans, and EEG recordings to find clues that might predict who is at risk. The goal is to better understand why some stroke survivors develop epilepsy.

This study follows about 300 children who had seizures shortly after birth to see if their genes influence whether they develop epilepsy later in childhood. Researchers will combine genetic information with brain scans and EEG results to create a risk score. No new treatments are…

This study looks at how focused ultrasound (sound waves) aimed at the cerebellum changes brain activity and thinking in 20 healthy adults aged 18 to 40. Participants do thinking tasks after real or fake ultrasound. The goal is to learn how the cerebellum affects brain function, n…

This study is testing whether a brain-based biomarker can predict how well stroke survivors recover from spatial neglect—a condition that makes it hard to notice things on one side. Researchers will follow 45 Veterans for 6 months, measuring their daily living skills and neglect …

This study looks at whether a special board game can help older adults (65-100) who had a mild to moderate stroke think about and share their preferences for life-sustaining treatments. The game uses travel themes and cards to make these tough conversations easier. Researchers me…

This study aims to build a research group of 100 people with neurological diseases like stroke, Parkinson's, epilepsy, or dementia. Researchers will use overnight sleep tests and questionnaires to measure sleep patterns, breathing, and heart rate during sleep. The goal is to bett…

This study followed over 6,800 adults from different racial and ethnic backgrounds to understand how heart disease develops over time. Participants were healthy at the start and were monitored for risk factors and heart-related events like heart attacks and strokes. The goal is t…

This study tests different ways to reach and enroll women and Black/Latino adults in heart disease research. Participants receive educational text messages about heart health and research opportunities. The goal is to see if these methods increase diversity and trust in clinical …

This study looks at brain activity and heart patterns in people who have had a stroke and compares them to healthy adults. Researchers use special head sensors and heart monitors to measure differences. The goal is to better understand how stroke changes the brain and heart. No t…

This study follows 10,000 people with both obstructive sleep apnea and high blood pressure over many years. Researchers will track how well patients use CPAP machines and blood pressure medications, and whether this reduces the chance of heart attacks, strokes, heart failure, or …

This observational study is testing whether a new digital imaging analysis can more accurately predict stroke risk in 400 adults with narrowed brain arteries (50-99% blockage). Participants undergo standard angiography, and researchers use a computer method to measure blood flow …

This study looks at how nerve reflexes in the thigh muscle affect walking in people who have had a stroke and have a stiff-knee gait. Researchers will use mild electrical stimulation to measure reflex activity while participants walk. The goal is to better understand why some str…

This study tests a new way to grade carotid plaques using ultrasound, called Plaque-RADS, to see if it can predict stroke risk better than current methods. Researchers will collect data from 855 people with asymptomatic carotid plaques, both from past records and new patients. Th…

This study looks at how people who have had a stroke use healthcare services over the long term. Researchers will review medical records of about 40,000 patients and interview 240 survivors to understand their needs and experiences. The goal is to find patterns and gaps in care, …

This study tests a new therapy program called REAP for stroke survivors in Bangladesh. The program helps people regain skills, educates families, adapts tasks, and promotes participation in daily life. Six adults who had a stroke 3-24 months ago will try the program to see if it …

This study aims to make it easier and more accurate to detect tiny blood clots (microemboli) in the brain, which are strong predictors of future strokes. Researchers will have experts analyze 850 recordings of brain blood flow signals to develop a standard way to identify these c…

This study is testing whether rehabilitation that combines physical and mental exercises (called dual-task training) can help people with stroke, multiple sclerosis, Parkinson's disease, or long COVID. Researchers will design and try out different dual-task strategies in small gr…

This study looks at 250 stroke patients to understand why some arrive late at the hospital. Researchers use a questionnaire, mapping tools, and brain scans to find social, transport, and knowledge barriers. A machine learning model will try to predict who is at risk for delay, wi…

This observational study is tracking 1,000 patients with stable atrial tachycardia to see how well different rhythm control treatments work over the long term. Researchers are focusing on serious outcomes like death, stroke, and heart-related hospital stays. The goal is to gather…

This study follows 600 people with and without chronic kidney disease (CKD) for up to four years to compare how often memory loss, confusion, and daily activity problems occur. Researchers will also look for risk factors that make thinking and memory worse in CKD patients. Partic…

This study follows over 19,000 older adults who previously took aspirin in a clinical trial. Researchers are monitoring them for delayed effects on cancer, dementia, disability, and death. The goal is to see if aspirin has any long-term benefits or risks years after stopping the …

This study gathers information from 8,000 stroke patients worldwide to learn more about seizures that happen after a stroke. Researchers will analyze the data to see how well patients recover and to create a tool that can predict who might develop epilepsy. The goal is to improve…

This study looks at how a soft robotic exosuit can help people who have had a stroke walk better. Researchers will measure muscle activity and walking patterns in 22 adults who are at least six months past their stroke. The goal is to see if customizing the exosuit's assistance b…

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor could also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation. The study was withdrawn before enrolling …

This study looks at how quickly stroke survivors process information and whether that speed affects their movement, balance, walking, and quality of life. Researchers will test 100 people who have had a first ischemic stroke. The goal is to understand if thinking speed should be …

This study looks at whether shoulder problems make balance worse for people who have had a stroke and have weakness on one side. Researchers will compare balance in 100 stroke survivors—some with shoulder pain and some without. The goal is to understand if treating shoulder issue…

This study looks at how common strokes and silent brain injuries are in young adults (ages 16-25) with sickle cell anemia, especially in Nigeria where the disease is widespread. Researchers will use brain scans and blood tests to check for damage and identify risk factors like hi…