Silent strokes in sickle cell adults: a hidden crisis revealed

NCT ID NCT03376893

Ongoing Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 102 adults with sickle cell disease to track how often silent and overt strokes occur. Participants undergo regular MRI scans and neurological exams over 3.5 years. The goal is to gather data that could lead to the first stroke prevention trials specifically for adults with this condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could provide the data needed to design the first clinical trials for stroke prevention in adults with sickle cell disease.
What could go wrong: This is an observational study, not a treatment trial. It only collects information and does not test any new therapy, so it cannot directly improve health outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

sickle cell disease sickle cell-beta plus-thalassemia sickle cell-beta zero-thalassemia sickle cell-beta-thalassemia disease syndrome stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANEMIA, SICKLE CELL SICKLE CELL DISEASE SICKLE CELL THALASSEMIA SICKLE CELL-BETA0-THALASSEMIA STROKE

Contacts and locations

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Locations

University of Alabama at Birmingham

Birmingham, Alabama, 35233, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232-9000, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States

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