Chilling the brain during stroke: could cold saline boost recovery?
NCT ID NCT07232082
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether cooling the brain with cold saline during clot-removal surgery helps people recover from severe strokes. About 322 adults with large strokes will be randomly assigned to get standard care or standard care plus local brain cooling. The main goal is to see if more patients are independent at 90 days after treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- intra-arterial cold saline infusion
- What this could lead to
- If it works, this could offer a new way to protect the brain during stroke treatment, potentially leading to better recovery for patients with large strokes.
- What could go wrong
- This is an early-stage trial with only 322 participants, so results may not apply to everyone. The cooling procedure carries risks like infection or vessel damage, and it may not improve outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for LARGE ISCHEMIC CORE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Spinal zaps could reboot breathing after brain injury
- Can brain scans reveal hidden language struggles after stroke?
- Can lifestyle choices after a stroke extend life and prevent a second one?
- A tablet test aims to catch hidden attention and memory problems after stroke
- Can a gentle ear zap supercharge stroke rehab at home?
- Can exercise boost reading recovery in stroke survivors?