New breathing technique could uncover hidden stroke cause
NCT ID NCT06670781
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two ways of performing the Valsalva maneuver during a heart ultrasound to detect a patent foramen ovale (PFO), a small hole in the heart that can cause strokes. About 488 stroke patients will be asked to do both a standard self-directed maneuver and a goal-directed maneuver using a manometer to measure their effort. The goal is to see if the goal-directed method finds more PFOs, which could lead to better treatment and fewer repeat strokes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Goal-directed Valsalva maneuver using a manometer device
What this could lead to
If successful, this could improve detection of PFO in stroke patients, leading to more accurate diagnosis and treatment to prevent recurrent strokes.
What could go wrong
This is a diagnostic method comparison, not a treatment trial. Even if it improves detection, it may not change patient outcomes. The study is still recruiting and results are not yet available.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Ottawa Heart Institute
NOT_YET_RECRUITINGOttawa, Ontario, K1Y 4W7, Canada
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University of Ottawa Heart Institute
RECRUITINGOttawa, Ontario, K1Y 4W7, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact