New breathing technique could uncover hidden stroke cause

NCT ID NCT06670781

Recruiting now Diagnosis Sponsor: Ottawa Heart Institute Research Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two ways of performing the Valsalva maneuver during a heart ultrasound to detect a patent foramen ovale (PFO), a small hole in the heart that can cause strokes. About 488 stroke patients will be asked to do both a standard self-directed maneuver and a goal-directed maneuver using a manometer to measure their effort. The goal is to see if the goal-directed method finds more PFOs, which could lead to better treatment and fewer repeat strokes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Goal-directed Valsalva maneuver using a manometer device
What this could lead to: If successful, this could improve detection of PFO in stroke patients, leading to more accurate diagnosis and treatment to prevent recurrent strokes.
What could go wrong: This is a diagnostic method comparison, not a treatment trial. Even if it improves detection, it may not change patient outcomes. The study is still recruiting and results are not yet available.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

patent foramen ovale stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STROKE

Contacts and locations

Locations

University of Ottawa Heart Institute
NOT_YET_RECRUITING

Ottawa, Ontario, K1Y 4W7, Canada
University of Ottawa Heart Institute
RECRUITING

Ottawa, Ontario, K1Y 4W7, Canada

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