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Could less radiation be better for HPV throat cancer?

NCT ID NCT07178301

Recruiting now Disease control Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 15, 2026 · Updated 4 times

Summary

This study tests whether giving a lower dose of radiation to the lymph nodes in the neck that are not directly affected by cancer can reduce side effects while still curing the disease. It includes 100 people with early-stage HPV-related throat cancer. The goal is to maintain excellent cancer control while improving quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
radiation therapy
What this could lead to
If successful, this could show that a lower radiation dose to the neck is safe and effective, reducing long-term side effects like swallowing problems and dry mouth.
What could go wrong
This is a small, early-phase trial with only 100 participants. The lower dose might not control the cancer as well, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

human papillomavirus-related squamous cell carcinoma oropharyngeal carcinoma oropharynx cancer oropharynx squamous cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLINICAL STAGE I HPV-MEDIATED (P16-POSITIVE) OROPHARYNGEAL CARCINOMA AJCC V8 CLINICAL STAGE II HPV-MEDIATED (P16-POSITIVE) OROPHARYNGEAL CARCINOMA AJCC V8

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Northwestern Medicine Warrenville

    RECRUITING

    Warrenville, Illinois, 60555, United States

    Contact Email: •••••@•••••

  • Northwestern University

    RECRUITING

    Chicago, Illinois, 60611, United States

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