Northwestern University

This early safety study tests an immunotherapy drug called N-803 in patients with two rare types of soft tissue sarcoma. The participants have already been treated with a personalized cell therapy, but their cancer has started to grow again. Researchers want to see if N-803 can s…

This study is testing whether customizing the length of muscle cuts during POEM surgery improves outcomes for people with swallowing disorders like achalasia. Researchers will compare standard surgery to shorter, tailored cuts for some patients and study longer cuts for others. P…

This study is testing a remote program to help new mothers who had elevated blood pressure during pregnancy become more physically active. Researchers will connect FitBit data to health records and send weekly feedback messages. The goal is to see if this approach increases daily…

This study is testing if a low dose of an existing cancer drug, erlotinib, can safely reduce the painful skin thickening and scaling caused by rare genetic skin disorders. It will involve 44 adults with confirmed diagnoses of conditions like epidermolytic ichthyosis. The goal is …

This study is testing whether sending patients automated advice about their home blood pressure readings helps control high blood pressure better than just tracking numbers manually. It will involve over 1,300 adults with uncontrolled high blood pressure who are patients at North…

This study is testing whether a lower dose of radiation to healthy lymph nodes in the neck can reduce treatment side effects while still effectively curing HPV-related throat cancer. It will enroll 100 adults with early-stage cancer who have not had prior treatment. The goal is t…

This early study is testing if adding a drug called Anakinra to the fluid that preserves donor lungs before transplant can prevent a serious complication called primary graft dysfunction. The complication causes low oxygen levels and lung inflammation after surgery. About 20 lung…

This study is testing a new surgical method called laparoscopic sclerotherapy to treat ovarian cysts caused by endometriosis. Instead of cutting out the cyst wall, surgeons drain the cyst and fill it with a concentrated alcohol solution to shrink it. The main goal is to see if th…

This study aims to find out which of two common kidney stone removal surgeries works better. Researchers will compare a surgery that goes through the back (mini-PCNL) with one that goes through the urinary tract (ureteroscopy) when both use a special suction tool. They want to se…

This trial is testing whether adding the drug valproic acid to standard emergency care can improve recovery for adults with moderate to severe traumatic brain injuries. Researchers will compare two different doses of the drug against a placebo to see which is safest and most effe…

This study compares two versions of a common surgery for achalasia, a condition that makes swallowing difficult. Researchers want to see if cutting less muscle during the procedure (about 1.25 inches instead of 3.5 inches) works just as well to relieve symptoms but causes fewer l…

This study tests a new computer tool designed to catch a common but often overlooked finding on emergency room scans: fatty liver disease. The AI system alerts doctors to the finding, provides a risk assessment for the patient, and suggests appropriate follow-up steps. The goal i…

This study is creating and testing a special version of a proven mental health program for parents expecting or raising a baby with Down syndrome. The goal is to prevent depression by helping parents process feelings of grief and connect with a supportive community. Researchers w…

This study is testing whether a text message program is practical and acceptable for helping young adults create safety plans when they have suicidal thoughts. Researchers want to see if they can run a larger future study and if participants find the text-based support helpful. T…

This early-stage study is testing whether a special cell treatment can help prevent rejection in people receiving a kidney from a living donor. Doctors take cells from the donor, treat them with light therapy, then give them to the recipient before and after transplant. The main …

This study is testing if having a physical therapist work right in the emergency room can help people who come in for dizziness. The goal is to see if starting therapy right away is a practical way to improve care. Researchers will compare two hospitals—one with the therapist in …

This study is testing which of three speech therapy approaches works best to improve communication skills in toddlers with developmental delays. It will enroll over 1,200 children to compare therapist-led sessions, parent coaching, and a combined approach. The goal is to identify…

This study is testing whether injecting alcohol or capsaicin (the compound that makes chili peppers hot) near painful nerve endings can provide longer-lasting relief for phantom limb pain and stump pain after amputation. It will involve about 120 adults with leg amputations who s…

This study is testing a new exercise program designed for older adults who have both a common heart rhythm problem (atrial fibrillation) and a type of heart failure. Researchers want to see if starting with strength training to build muscle makes it easier and more effective to t…

This study is testing whether a new smartphone app can help teenagers who hurt themselves on purpose (nonsuicidal self-injury). The app uses a chatbot to teach coping skills and provide support. Researchers want to see if the app is easy to use and acceptable to teens before laun…

This study is testing whether a simple vibration tool can help control pain after surgery for a broken wrist. Researchers want to see if this non-drug approach can reduce patients' pain and their need for opioid pain medication. The study will involve 100 patients who are receivi…

This study follows older adults over time to understand how they make decisions about staying in their homes or moving to care facilities as they age, particularly if they develop Alzheimer's disease or memory loss. Researchers will track how factors like health changes, family s…

This study aims to see if offering education and genetic testing for alcohol flushing is practical and influences health behaviors. Researchers will compare two groups: one receives education plus a genetic test, while the other receives education alone. The goal is to learn if a…

Micronutrient deficiencies are common in ulcerative colitis (UC). Selenium deficiency is associated with worse disease outcomes including disease flares and need for surgery. Previous in vitro and in vivo studies demonstrated that selenium regulates colonic inflammation, and that…