Northwestern University

This study is for adults with liver cancer that cannot be removed by surgery or standard treatments. It tests different doses of radiation delivered directly to the liver to find the amount that completely destroys the tumor. The goal is to improve treatment and understand how li…

This study tests a less invasive surgery called laparoscopic sclerotherapy for ovarian cysts (endometriomas) caused by endometriosis. The goal is to see if this method better protects a woman's egg supply (ovarian reserve) compared to standard cyst removal. Twenty women with cyst…

This study tests whether a single dose of valproic acid, a drug already used for seizures, can improve recovery in people with moderate to severe traumatic brain injury (TBI). About 432 adults aged 18-65 will be randomly assigned to receive either standard care plus a placebo or …

This early-stage trial tests whether giving kidney transplant recipients a special infusion of their donor's treated cells, followed by regular light-based therapy, can safely reduce the risk of organ rejection. About 24 adults with kidney failure receiving a first transplant fro…

This study looks at whether automatically sending home blood pressure readings to doctors and getting automated advice through a patient portal can help lower blood pressure better than just writing numbers down. About 1,300 adults with uncontrolled high blood pressure will take …

This study tests a low-dose cancer drug called erlotinib to treat rare genetic skin disorders that cause severe thickening, scaling, and pain. About 44 adults with conditions like epidermolytic ichthyosis or palmoplantar keratoderma will take the drug daily for 24 weeks. The goal…

This study tests a computer program that helps emergency room doctors notice fatty liver disease on scans, tell patients about it, and suggest next steps. About 4,700 adults who have fatty liver found by accident on an ER scan will take part. The goal is to make sure these findin…

This study tests a program called S.A.F.E. Firearm in up to 15 Illinois health centers. Doctors will talk with parents about safely storing firearms and offer a free cable lock during well-child visits. The goal is to see if this approach helps more families keep guns locked up a…

This study tests a personalized approach for veterans with a lower leg amputation. Participants will try different prosthetic foot styles to find their favorite, then receive either standard care or a custom physical therapy program for eight weeks. The goal is to see if matching…

This study tests if a shorter muscle cut in the esophagus works as well as the standard longer cut for people with swallowing problems from achalasia. About 372 adults with certain types of achalasia will be randomly assigned to get either the shorter or standard procedure. Resea…

This study tests a smartphone app designed to help teens aged 14-18 who self-harm and are not currently in therapy. The app provides either interactive support or educational information. The main goal is to see if the app is acceptable and easy to use, and to prepare for a large…

This study looks at whether a treatment chair called Emsella can help men who have temporary stress urinary incontinence (leaking urine when coughing or sneezing) after a common prostate surgery called HoLEP. About 30 men with enlarged prostates will receive Emsella sessions befo…

This study tests a new exercise approach for people aged 60 and older who have both atrial fibrillation (an irregular heartbeat) and a type of heart failure called HFpEF. The program starts with resistance training to build muscle strength, then adds aerobic exercise to improve s…

This study aims to see if injecting alcohol or capsaicin (a chili pepper extract) into painful nerve endings can reduce phantom limb pain and stump pain in people who have had an amputation. It will involve 120 adults with lower or upper limb amputations who still have significan…

This study looks at whether offering genetic testing for alcohol flushing, along with education, is practical and helpful for East Asian American adults. About 100 people who experience flushing when drinking or have a family history of it will take part. Half will get education …

This study follows 285 older adults (65+) with Alzheimer's or mild cognitive impairment, along with their caregivers, to learn how they make decisions about staying at home or moving to a care facility. Researchers will track their planning over time through simple questions abou…