Northwestern University

This study is testing whether an immunotherapy drug called vudalimab can shrink tumors in patients with advanced anaplastic thyroid cancer or Hurthle cell thyroid cancer. The drug is designed to help the patient's own immune system attack the cancer. The trial will enroll about 5…

This study is testing whether combining two existing drugs works better than using them alone for men with advanced prostate cancer that has specific genetic flaws. It is for men whose cancer has spread and is no longer responding to standard hormone-blocking treatments. The tria…

This study is testing whether a commercial lemonade drink or a potassium citrate supplement can change the chemistry of a person's urine to make it less likely for kidney stones to form. It involves 10 adults with a history of kidney stones and specific urine test results. Partic…

This study is testing if a single injection of a medication called Etanercept, given right before a lung transplant, can help prevent kidney injury after the surgery. It will involve 20 patients at Northwestern Memorial Hospital who are scheduled for a lung transplant. Researcher…

This study aimed to find out if adding a chemotherapy drug (docetaxel) to a standard two-drug hormone therapy regimen works better for controlling prostate cancer that has spread but is still limited in volume. Men with this specific type of cancer would have been randomly assign…

This early-stage trial is testing whether adding a drug called mycophenolate mofetil (MMF) to standard glioblastoma treatment is safe and might make the cancer more sensitive to chemotherapy. MMF is an immunosuppressant commonly used to prevent organ rejection after transplants. …

This study is testing a new smartphone app designed to help teenagers who are involved with the court system reduce or stop their marijuana use. The app, called TECH, creates a private online community where teens can work on changing their behavior with support from other anonym…

This study is testing if adding a common diabetes drug, metformin, to the standard hormone therapy (megestrol acetate) works better to control a uterine pre-cancer condition. It involves 51 women who are already scheduled for a hysterectomy or IUD placement. The goal is to see if…

This is an early, small study to find a safe and active dose of a new oral drug called tomivosertib for adults with acute myeloid leukemia (AML) that has returned or not responded to prior treatments. Up to 15 participants will take the pill daily in 28-day cycles while doctors c…

This early-stage study is testing a new drug combination for adults whose aggressive brain cancer (glioblastoma) has returned. Researchers want to find the safest and most effective dose of an experimental drug called triapine when given with the standard chemotherapy temozolomid…

This study is testing whether a combination of two drugs, epcoritamab and lenalidomide, can help control a specific type of aggressive lymphoma that has come back or hasn't responded to other treatments. The trial is for adults whose cancer is linked to a weakened immune system a…

This study is testing if lisinopril, a medication commonly used for high blood pressure, can help slow or prevent the progression of advanced fatty liver disease (NAFLD). It involves about 45 adults who already have significant liver scarring. Participants take the drug daily for…

This study is testing a new type of arm exercise therapy for people who have had a recent stroke. The goal is to help prevent a common problem called 'flexion synergy,' which makes it very hard to reach outward with the affected arm. About 86 participants will receive either the …

This study is testing a smartphone app designed to help adults with obesity and frequent binge eating. It aims to figure out which app features and messages work best to reduce binge eating episodes and support weight-related goals. The app sends timely suggestions and support to…

This study aims to find the best way to control advanced liver cancer. It tests whether a one-time targeted radiation treatment to the liver works better when followed by one of two standard drug combinations. The goal is to see which sequence keeps the cancer from growing longer…

This study is testing the safety and best dose of an experimental drug, nintedanib, when combined with an approved drug, azacitidine. It is for older adults with a specific type of acute myeloid leukemia who are not candidates for or choose to avoid intensive chemotherapy. The ma…

This study is testing if a structured checklist can help coordinate cancer care services as effectively as traditional one-on-one support. It involves 600 Chinese adults in specific Chicago neighborhoods. The goal is to see if the checklist helps people get recommended cancer scr…

This study is checking if a special 6-month parent coaching program given to families of deaf or hard-of-hearing toddlers has lasting benefits years later. Researchers are following 88 children into early elementary school to see if those whose parents received the coaching have …

This study is testing a program called OPTIMIZE, which uses a detailed checklist and a personal support guide (patient navigator) to help ensure African American pregnant women receive recommended medical and social care. It compares this program to standard care across about 20 …

This study is collecting skin photos from people with a rare genetic skin condition called recessive dystrophic epidermolysis bullosa (RDEB) who have had skin cancer. Researchers are using these photos to train an artificial intelligence (AI) model. The goal is to create a smartp…

This study aimed to test a new type of imaging scan to see if it could better identify aggressive prostate cancer. It planned to compare a special PET/MRI scan to a standard MRI scan in men with elevated PSA levels who were scheduled for a biopsy. The goal was to improve the accu…

This study is testing a new, quick iPad-based tool called ToolboxDetect to help primary care doctors spot early signs of memory and thinking problems in older adults during their annual wellness visits. It aims to see if this 7-8 minute test is better than usual care at finding c…

This study is testing two simple, low-cost programs to help people with prediabetes start treatments known to prevent type 2 diabetes. It involves 960 adults from primary care clinics. The programs use a decision aid or text messages to encourage people to begin a lifestyle chang…

This study is testing two different methods to encourage family members of people with a genetic high cholesterol condition (familial hypercholesterolemia) to get screened themselves. Researchers will compare automated messages from a health system and support from a patient navi…

This study is testing if atorvastatin, a common cholesterol-lowering drug, can help prevent colon cancer in people with long-term ulcerative colitis who have a specific genetic change. It involves 42 adults who will take either atorvastatin or a placebo pill daily for one year. R…

This study is testing if a widely used, safe diabetes medication called metformin can lower the chance of developing lung cancer. It involves 50 overweight former and current smokers who are at high risk for the disease. Researchers want to see if taking metformin daily for six m…

This small pilot study aims to see if the pain medication naproxen helps people with painful knee osteoarthritis feel better. Twenty participants will try both naproxen and a placebo pill in a random order over several weeks, with breaks in between. Researchers will track daily p…

This early study is testing a special bubble bath treatment called Thera-Clean for people with skin conditions like eczema, psoriasis, and epidermolysis bullosa. The treatment uses tiny bubbles to clean skin and wounds without chemicals, aiming to reduce itching, pain, odor, and …

This study aimed to see if a gentle, non-invasive device worn on the neck could help patients wake up faster and more clearly after spinal surgery. It planned to test if this stimulation could reduce post-surgery confusion and low mood, potentially helping patients leave the reco…

This study is testing a 12-week smartphone program designed to help young adult cancer survivors become more physically active. Researchers are comparing different features, like having a support buddy, a coach, or mindfulness training, to see which ones work best. The goal is to…

This study is testing a smartphone app designed to help breast cancer survivors become more physically active and practice mindfulness. Over 300 participants will use a fitness tracker and app for 24 weeks, with some also getting support from a buddy, a coach, or mindfulness less…

This study aims to understand if two common prostate cancer drugs, abiraterone and enzalutamide, affect memory, concentration, and other thinking skills. Researchers will use brain scans and cognitive tests to compare 100 men with advanced prostate cancer who are taking these dru…

This study aims to understand how older adults make decisions about future care, especially if they develop memory problems like Alzheimer's. Researchers gave 293 participants access to a web-based planning tool and followed them for over three years to see what factors influence…

This study aims to understand why a gel medication for breast cancer might be absorbed differently through each woman's skin. Researchers are testing the gel on breast cancer survivors who have had radiation on one breast, to see how skin features and past radiation affect drug d…

This study is testing if a short educational video can help pregnant women better understand the anesthesia process for a scheduled C-section. Researchers want to see if watching the video before meeting the anesthesiologist improves how informed patients feel about their choices…

This study aims to better understand which adults with liver cirrhosis are most at risk for serious health complications. It will follow over 1,200 participants with liver scarring, checking in with them every six months to collect health data, images, and samples. The goal is to…

This study aimed to see if two special tests could better predict which patients with severe, hard-to-treat gastroparesis would get better from a specific endoscopic surgery called G-POEM. The goal was to help doctors choose the right patients for this procedure by measuring how …

This study aims to better understand how a common brain stimulation technique works. It is for people already scheduled for brain surgery to treat epilepsy or remove a tumor. Researchers will use the stimulation and a safe cooling technique during surgery to learn how it affects …