Northwestern University

This study tests three treatment options for men with advanced prostate cancer that no longer responds to hormone therapy and has specific DNA repair defects. Participants receive either abiraterone (a hormone blocker), olaparib (a targeted drug), or both together. The goal is to…

This early-phase study tests an experimental drug called tomivosertib in 15 adults whose acute myeloid leukemia (AML) has returned or not responded to standard treatments. The main goal is to find the safest and most effective dose by monitoring side effects and any signs that th…

This study looks at whether adding metformin (a diabetes drug) to standard hormone therapy (megestrol acetate) can better control uterine pre-cancer and stop it from becoming cancer. About 51 women with this pre-cancer condition will receive either the standard drug alone or the …

This study looks at whether a popular lemonade drink, potassium citrate, or both can reduce the risk of forming kidney stones. Ten adults with a history of stones and low urine citrate or acid will be followed. The goal is to see if these treatments can change urine chemistry to …

This study tests a drug called vudalimab in people with advanced anaplastic thyroid cancer or hurthle cell thyroid cancer that has spread. The drug helps the immune system attack cancer cells and may slow tumor growth. About 54 participants will receive the treatment to see if tu…

This study tests whether lisinopril, a widely used blood pressure medication, can slow the progression of non-alcoholic fatty liver disease (NAFLD) and lower the risk of liver cancer. About 45 adults with advanced liver scarring (fibrosis) will take lisinopril for a period, and r…

This study tests whether combining two immune-boosting drugs, epcoritamab and lenalidomide, can shrink or eliminate lymphoma in 34 patients whose cancer did not respond to prior treatment or came back. The participants have a type of lymphoma linked to a weakened immune system, s…

This study is for adults with advanced liver cancer. It compares two treatment plans after a procedure that delivers radiation beads (Therasphere) into the liver: one group gets immunotherapy (atezolizumab and bevacizumab), the other gets targeted pills (lenvatinib or cabozantini…

This trial tests a device implanted in the skull that uses ultrasound to temporarily open the blood-brain barrier, allowing chemotherapy drugs to reach brain tumors more effectively. About 57 adults with recurrent glioblastoma will receive this treatment after surgery to remove t…

This study was designed to see if a special PET/MRI scan can better detect serious prostate cancer in men with elevated PSA levels. Participants would have received an injectable radioactive tracer that attaches to prostate cancer cells, followed by imaging. The goal was to compa…

This study tests whether metformin, a safe and widely used diabetes medicine, can reduce the risk of lung cancer in overweight or obese former smokers who are at high risk. About 50 participants will take metformin extended-release pills for 6 months. Researchers will measure cha…

This study tests whether simple reminders and encouragement (behavioral nudges) can help adults with prediabetes take proven steps to prevent diabetes, such as joining a lifestyle program or taking metformin. About 960 English- or Spanish-speaking adults aged 18-80 with prediabet…

This study tests a special arm exercise program for people who recently had a stroke and have trouble reaching outward. 86 participants will do either the new exercise or standard therapy during rehab and be followed for a year. The goal is to see if the exercise helps reduce arm…

This pilot study tests whether nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce pain in people with knee osteoarthritis. About 20 adults over age 40 with moderate to severe knee pain will try different NSAID treatments in a crossover design. The goal is to see which drug …

This early study tests whether a low-dose oral medication (minoxidil) can help regrow hair in people who have permanent hair loss after chemotherapy. Fourteen adults who finished chemo at least six months ago will take the pill and be checked every 12 weeks for hair regrowth and …

This study compares a newer laser technology (Moses 2.0) with the standard laser for breaking up kidney stones. About 150 adults with stones between 6 and 20 mm will be treated. The goal is to see which method reduces surgery time and clears stones more completely.

This early study tests a special microbubble bath (Thera-Clean) that uses no chemicals to clean skin, reduce itch, and help wounds heal. About 20 people aged 2 and older with epidermolysis bullosa, ichthyosis, atopic dermatitis, or psoriasis will use the bath at home for 8 weeks.…

This study tests four add-on features (e-coaching, a buddy, general mindfulness, and exercise-specific mindfulness) in a 12-week mobile health program for 304 young adult cancer survivors. The goal is to see which features best increase moderate-to-vigorous physical activity and …

This study looks at whether hearing aid settings tailored to a person's unique listening style can improve their ability to understand speech in noisy environments. Researchers will compare customized settings to a one-size-fits-all approach. Participants will attend a 2-hour lab…

This study was designed to see if a noninvasive device that stimulates the vagus nerve (tcVNS) could help patients regain consciousness faster after anesthesia, and reduce delirium and depression after surgery. It planned to enroll adults undergoing lumbar spine surgery. However,…

This study tests a mobile app that sends personalized tips to help people stop binge eating and lose weight. Researchers want to learn which strategies work best for different people and in what order. About 300 adults with obesity and frequent binge eating will use the app for s…

This study looks at whether showing a short video to pregnant women at least 24 hours before a scheduled C-section helps them better understand the risks and benefits of anesthesia. About 70 English-speaking adults will take part. The goal is to see if the video improves how well…

This study looks at 60 adults with cochlear implants to see if simple vision tests can predict how well they understand speech in noisy environments. Because the implant's sound signal is distorted, users rely heavily on brain processing. The researchers will compare results from…

This study looks at how a medicated gel (afimoxifene) is absorbed through the skin of the breast in women who have had radiation therapy for breast cancer. Researchers want to understand if skin type, blood vessels, or past radiation affect how much of the drug reaches breast tis…

This study tests whether simple electronic reminders (called nudges) can help doctors reduce high-risk medication use in older adults, especially those with dementia. About 786 patients from primary care clinics will take part, and clinics are randomly assigned to receive differe…

This study follows 88 deaf or hard-of-hearing children who, as toddlers, were randomly assigned to either a 6-month parent coaching program or usual care. Researchers now want to see if the coaching led to better language, reading, and social skills in early elementary school. Pa…

This study looks at skin and blood samples from 505 children with eczema (atopic dermatitis) to find biological markers that explain the disease. Researchers compare these markers to those in adults to better understand what causes eczema in kids. No new treatments are tested; th…

This study looks at whether giving patients access to a website called WellPrept helps them feel more confident and informed about their upcoming prostate or kidney stone surgery. Researchers will measure if the tool shortens time spent in clinic visits and reduces trips to the e…

This study looks at two methods to encourage family members of people with familial hypercholesterolemia (FH) to get screened for the condition. About 800 adults with FH from Penn Medicine will be assigned to receive automated health system messages, help from a patient navigator…

This study was designed to see if two special probes could predict which patients with severe stomach paralysis (gastroparesis) would get better from a procedure called G-POEM. The researchers planned to measure stomach muscle function before the procedure. However, the study was…