Simple surgical tweak may cut prolapse return rate

NCT ID NCT04880239

Ongoing Disease control Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding a posterior repair (tightening the vaginal opening) to standard prolapse surgery helps prevent the prolapse from returning within a year. About 200 women with advanced prolapse are taking part. Half get the extra procedure, half do not, and researchers compare recurrence rates.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Posterior colpoperineorrhaphy (a surgical procedure to tighten the vaginal opening)
What this could lead to: If successful, this could show that adding a simple vaginal tightening step during prolapse surgery lowers the chance of prolapse coming back within a year.
What could go wrong: This is a relatively small, single-center trial, so results may not apply to all women. The added procedure could also increase pain or bowel issues without preventing recurrence.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pelvic organ prolapse Prolapse prolapse of female genital organ

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROLAPSE; FEMALE

Contacts and locations

Locations

Northwestern University

Chicago, Illinois, 60611, United States

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