Diabetes drug metformin tested to prevent lung cancer in overweight former smokers
NCT ID NCT04931017
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests whether metformin, a safe and widely used diabetes drug, can lower the risk of lung cancer in overweight or obese former smokers who are at high risk. About 50 participants will take metformin for 6 months to see if it reduces certain immune cells linked to tumor growth. The goal is to find a simple, low-cost way to prevent lung cancer in this vulnerable group.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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BC Cancer Research Centre
Vancouver, British Columbia, V5Z 1L3, Canada
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Rocky Mountain Regional VA Medical Center
Aurora, Colorado, 80045, United States
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Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
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University of British Columbia Hospital
Vancouver, British Columbia, V6T 2B5, Canada