Could a blood pressure pill protect your liver from cancer?

NCT ID NCT04550481

Ongoing Disease control Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This phase II trial tests whether lisinopril, a widely used blood pressure medication, can prevent liver damage from getting worse in people with non-alcoholic fatty liver disease (NAFLD). The study enrolls 45 adults with advanced liver scarring and measures changes in fibrosis markers over time. If successful, lisinopril could offer a simple, repurposed treatment to reduce liver cancer risk.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lisinopril
What this could lead to: If it works, this could point toward a new use for a common blood pressure drug to slow liver damage and lower liver cancer risk in people with fatty liver disease.
What could go wrong: This is a small, early-phase trial with only 45 participants, so results may not apply widely. Lisinopril may not reduce fibrosis or cancer risk as hoped, and it can cause side effects like dizziness or kidney issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease hepatocellular carcinoma prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATOCELLULAR CARCINOMA NONALCOHOLIC STEATOHEPATITIS

Contacts and locations

Locations

Cedars Sinai Medical Center

Los Angeles, California, 90048, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States
Mount Sinai Hospital

New York, New York, 10029, United States

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