Can a simple pill make fibroid surgery safer?
NCT ID NCT07286188
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether giving misoprostol (a drug often used for stomach ulcers and labor) before hysteroscopic fibroid removal can reduce the amount of fluid absorbed by the body during surgery. Too much fluid can be dangerous. Forty women with small fibroids (1-3 cm) will receive either misoprostol or a placebo rectally before their procedure. The main goal is to see if misoprostol lowers fluid deficit, with secondary looks at surgery time and need for repeat procedures.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- misoprostol
- What this could lead to
- If it works, this could help reduce the risk of fluid overload during hysteroscopic fibroid surgery, making the procedure safer.
- What could go wrong
- This is a small, early-phase trial with only 40 participants, so results may not apply widely. Misoprostol may not reduce fluid deficit or could cause side effects like cramping or nausea.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Northwestern
RECRUITINGChicago, Illinois, 60611, United States
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