New Non-Addictive pain drug could curb opioid dependence after surgery

NCT ID NCT07672015

Recruiting now Disease control Sponsor: University of California, San Diego Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 4 times

Summary

This study tests whether suzetrigine, a non-opioid painkiller, can help patients who are at high risk for long-term opioid use after surgery. About 100 people having major orthopedic surgery will be randomly assigned to receive either standard pain care or standard care plus suzetrigine for 14 days. The main goal is to see if suzetrigine reduces the total amount of opioids taken after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Suzetrigine (Journavx), a non-opioid painkiller
What this could lead to: If successful, this could offer a safer, non-addictive way to manage post-surgery pain and reduce the risk of long-term opioid use.
What could go wrong: This is a small, early-phase trial with only 100 participants, so results may not apply to everyone. The drug may not reduce opioid use as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID CONSUMPTION, POSTOPERATIVE

Contacts and locations

Locations

University of California, San Diego
RECRUITING

La Jolla, California, 92037, United States

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