University Of California, San Diego

This study is comparing two different surgical implants used to repair a severe type of ankle ligament injury that often happens with a broken ankle. Researchers want to find out if one method (a suture button) leads to better recovery than the other (a Fibulink implant). They wi…

This early-stage study aims to find a safe dose of fampridine (a multiple sclerosis drug) when combined with the cancer drug imatinib (Gleevec) for patients with a specific type of gastrointestinal stromal tumor (GIST). Researchers want to see if this two-drug combination is more…

This study is testing whether adding an immunotherapy drug (cemiplimab) to a standard chemotherapy (gemcitabine) can help people with advanced pancreatic cancer that has a specific genetic change (SWI/SNF alteration) and has worsened after their first treatment. The goal is to se…

This early-stage trial is testing whether adding a pill called ruxolitinib to an immunotherapy drug (retifanlimab) is safe and can help control advanced lung or kidney cancer that has started growing again after prior immunotherapy. The study will enroll about 40 participants to …

This is the first study in people to test a new oral drug called SB-4826 for advanced solid tumors and non-Hodgkin lymphoma. The main goals are to find the highest safe dose and see how the body processes the drug. For lymphoma patients, the drug will also be tested in combinatio…

This study is testing a telehealth program designed to help young cancer patients access fertility preservation services. It aims to see if the program helps more patients get the fertility care that matches their personal goals and reduces the stress of making these decisions. T…

This study is testing a more targeted form of radiation therapy for men with intermediate- or high-risk prostate cancer. It aims to deliver a strong dose to the tumor while using a lower dose on the rest of the prostate, which may protect nearby organs like the bladder and rectum…

This study tests whether magnetic stimulation applied to both sides of the brain works better than stimulation on just the left side for reducing suicidal thoughts in people with treatment-resistant depression. Researchers will enroll 76 adults who still have suicidal thoughts de…

This study aims to find out if having an empty bladder during radiation therapy for pelvic cancers causes fewer side effects than the current standard of having a full bladder. It will enroll 300 adults with pelvic cancers who are receiving radiation with curative intent. Partici…

This study is testing a new surgical device called the TRUMATCH Graft Cage to help heal severe long bone fractures where a segment of bone is missing. It will follow 5 adult patients at UCSD for 3 years to see how well the bone heals, how quickly people recover, and if there are …

This study is testing if a strict high-fat, low-carb (ketogenic) diet can help control the persistent, distressing thoughts and behaviors in people with anorexia or bulimia. It will involve about 55 adults who are either at a normal weight but still struggling, are underweight, o…

This study is testing a new design of surgical nail used to fix broken thigh bones. It will follow 40 adult patients at UCSD for three years to see how well their fractures heal, their pain levels, and if there are fewer complications compared to older nail designs. The goal is t…

This study is testing if limiting daily eating to an 8-12 hour window can improve long-term health for people with metabolic syndrome, a condition that increases the risk of heart disease and diabetes. Over 54 weeks, 140 participants will either follow this time-restricted eating…

This study is testing a 12-week program called iTEST that combines daily cognitive exercises on a smartphone with personal coaching. The goal is to help adults with schizophrenia or similar conditions better judge their own abilities, which researchers believe could improve their…

This study tests whether the drug elranatamab can control multiple myeloma that has returned or stopped responding to previous treatments. It's for patients who have tried 1-3 different treatment combinations already. The approach is unique because patients who show a very deep r…

This study is testing whether extra support from community health workers helps refugees with high blood pressure take their medication more consistently and better control their blood pressure. Researchers will compare 250 participants who receive this special support to those w…

This study is testing whether restricting eating to a 10-hour window each day (fasting for 14 hours overnight) can help slow cognitive decline in people with mild cognitive impairment or early Alzheimer's disease. Researchers will enroll 60 older adults to follow this eating patt…

This study is testing a new, personalized coaching program called PRECISE for adults at high risk of suicide. It uses daily smartphone check-ins to understand what triggers each person's suicidal thoughts, then tailors coping skills and safety plans specifically for them. Researc…

This study is testing a new support program for young women who have survived cancer and live in rural areas. The program aims to help them get the reproductive healthcare they want, whether it's related to fertility, birth control, or other needs. Researchers will work with 64 p…

This study is testing whether adding a CBD (cannabidiol) oil solution to standard antipsychotic medication helps people with early psychosis. About 120 participants will take either CBD or a placebo for 8 weeks to see if it improves symptoms, thinking skills, and reduces inflamma…

This study aims to improve health for women living with HIV by making cervical cancer screening and treatment a standard part of their existing HIV care. It will test two different sets of support strategies in Nigeria to see which one works better to get more women screened and …

This study is testing a new plan for helping very premature babies breathe on their own. It compares a structured approach that keeps babies on a CPAP breathing machine until they are more developed (32-34 weeks) against the usual care decided by doctors. The goal is to see if th…

This study is testing whether giving families free vouchers for fresh fruits and vegetables can help children with type 2 diabetes. Researchers will provide vouchers to 200 families in California and track if this improves the children's diet, blood sugar levels, and reduces hous…

This study is testing a program that connects families struggling to afford healthy food with community support through their child's doctor's office. It aims to see if this approach is practical and acceptable, and if it can improve food security and health measures like weight …

This study is testing a 4-month online program called Women SHINE. It aims to help women living with HIV who have experienced violence and are struggling to take their medication as prescribed. The program provides peer support, group sessions, and online resources. Researchers w…

This study is testing whether a type of gentle brain stimulation, called tDCS, can be safely done at home by people with depression that hasn't improved with standard treatments. Ten participants will self-administer the 20-minute stimulation sessions at home, five times a day fo…

This study is testing whether an artificial intelligence (AI) model can help doctors choose the next treatment for people with advanced breast cancer. It focuses on patients whose cancer has started growing again after their first targeted therapy. The AI will analyze tumor data …

This study aims to find the safest and most effective dose of the drug levetiracetam to control seizures in newborn babies. Researchers will test increasingly higher doses in up to 133 newborns who have mild to moderate seizures, comparing them to a standard treatment. The goal i…

This study is testing a 6-month telehealth program designed to teach parents of children with autism how to help manage their child's weight. It will compare this behavioral program to a general health education course. Researchers will follow 150 families for 18 months to see wh…

This study is testing if adding precise, high-dose radiation to standard cancer drugs can help people with cancer that has spread to only a few spots. It will compare two groups: one gets radiation plus standard drugs, and the other gets just the standard drugs. The main goal is …

This study is testing whether a special computer-based brain training program can help people with anxiety, depression, or PTSD. Participants will be randomly assigned to use either the active training program or a less effective 'sham' version. Researchers will measure changes i…

This study is testing whether adding an anti-inflammatory diet to standard care helps people with rheumatoid arthritis feel better and reduces their disease activity. Researchers will enroll 124 adults whose arthritis is currently stable but active, and randomly assign them to fo…

This study is testing whether two different immunotherapy drug combinations can shrink high-risk basal cell skin cancers before surgery. About 30 patients will receive either a two-drug combo (Opdualag) or a single drug (Nivolumab) for a few months. The main goal is to see how we…

This study is testing a small marker device called OneMark to see if it helps doctors better locate breast cancer. It will be compared to a standard marker during surgery and checked over time in patients being monitored. The goal is to see if OneMark is easier for surgeons and r…

This study is testing whether a special 3D ultrasound imaging method can help doctors better monitor how liver cancer responds to treatment. Researchers will use this imaging technique on 80 adults with liver tumors who are starting new cancer therapy. The goal is to see if this …

This study is testing a computer tool designed to help doctors diagnose Kawasaki Disease, a serious childhood illness that causes inflammation of blood vessels. The tool analyzes a child's symptoms and lab results to predict if they have the disease. Researchers want to see if us…

This study is testing new ultrasound analysis techniques to detect and measure fatty liver disease in children without invasive procedures. Researchers will enroll 120 children aged 9-18 who have risk factors for fatty liver disease. They'll compare the accuracy of these new ultr…

This long-term study aims to find the best ways to detect glaucoma and track its progression, especially in people with nearsightedness (myopia) and people of African or European descent. Researchers will use advanced eye imaging technology to monitor the health of the optic nerv…

This study is testing a behavioral program designed to help Latinas with obesity and prediabetes. The program teaches strategies to manage food cravings and urges. Researchers want to see if it helps participants lose weight and prevent the development of Type 2 diabetes.

This study is testing which of three methods for delivering an antibiotic (vancomycin) is most effective at preventing serious infections after knee replacement surgery. Researchers are comparing injections directly into the joint, into the bone, or through an IV. The goal is to …

This study is testing a new pre-surgery training method for people who need their ileostomy (a surgical opening in the abdomen) reversed. Researchers want to see if putting a small amount of the patient's own ostomy bag contents back into their intestine for several weeks before …

This early-stage study is testing whether psilocybin-assisted therapy can help reduce burnout in physicians. Ten doctors from UC San Diego who have experienced burnout for over six months will receive therapy sessions combined with a dose of psilocybin. Researchers will check if …

This study is testing whether a 10-session meditative neurofeedback program can help reduce depression symptoms. Researchers are enrolling 27 adults with moderate depression to try this brain-training approach. The program aims to improve mood while also reducing repetitive negat…

This study is testing whether using a free app for seven weeks can help students feel better. The app tracks a person's natural daily energy patterns (their 'body clock') and suggests the best times for different activities. Researchers want to see if this helps improve students'…

This study is testing a new smartphone app called mSITE, designed to help adults with schizophrenia or similar conditions become more socially active. The app combines brief in-person therapy with phone-based reminders and coaching to encourage real-world social interactions. Res…

This study is testing whether dietary changes are a practical way to help college students with mild to moderate depression. Researchers will see if students can stick to a Mediterranean diet, or that diet combined with eating only within a 10-hour window each day. The main goal …

This study is testing whether a mental health app can help teenage dancers recover from foot or ankle injuries. Researchers want to see if using the app improves their emotional well-being, pain, and ability to return to dance. About 50 dancers aged 13-18 will be randomly assigne…

This study is testing a 16-week online exercise program designed for people recovering from breast cancer surgery. Participants join live video classes twice a week, focusing on aerobic fitness, strength, and balance. The program aims to see if this convenient, group-based approa…

This study is testing whether a topical gel called TriCalm Hydrogel can reduce severe itching, a common and distressing side effect of cancer immunotherapy drugs. It will compare the gel against a standard steroid cream in about 28 adults receiving immunotherapy at UC San Diego. …

This study is testing if a procedure that freezes a specific nerve can reduce chronic pain caused by diabetic neuropathy in the foot. 30 adult participants with diabetes and daily foot pain will be randomly assigned to receive either the real freezing procedure or a sham (fake) p…

This study aims to see if mood and sleep problems during menopause can be improved by resetting the body's internal clock. Researchers will test whether one night of specific sleep timing followed by two weeks of daily bright light exposure helps. They are recruiting 120 perimeno…

This study aims to understand how testosterone therapy affects menstrual cycles and reproductive hormones. Researchers will track hormone levels and menstrual patterns in transgender men starting testosterone therapy and compare them to cisgender women not on therapy. The goal is…

This study aims to understand and predict which cancer patients might experience brain-related side effects after receiving CAR T-cell therapy. Researchers will use brain scans, memory tests, and blood samples from 36 adult patients to look for early warning signs. The goal is to…

This research aims to understand how people who know two languages control and switch between them during different tasks like listening, speaking, and naming pictures. The study will involve 360 healthy adults who are proficient in either Mandarin and English or American Sign La…

This study aims to understand how two main cannabis compounds, THC and CBD, affect thinking skills like decision-making, attention, and motivation in people living with HIV. Researchers will compare 138 participants with and without HIV who don't use cannabis often, giving them a…

This study aims to understand how often atrial fibrillation (an irregular heart rhythm) returns in people who developed it during a serious illness or surgery. Researchers will monitor 100 patients for one year using small implanted heart monitors to track rhythm patterns. The go…

This study aims to see if a virtual reality test can reliably measure how much attention smokers pay to smoking-related cues, which could serve as a biomarker for addiction. Researchers will enroll 200 daily smokers from San Diego. Participants will take the VR test, then be rand…

This study is testing a team meeting method called an After-Action Review to improve how child welfare teams work with families. Researchers want to see if this approach helps families feel more involved in planning and increases follow-through on mental health services for child…

This large study aims to understand how often and how respiratory viruses like COVID-19, flu, and RSV spread in communities and households. It will enroll up to 25,000 people, including families, to track infections through regular symptom checks and at-home test kits. The goal i…

This study is testing a program called COMPRENDO, which uses trained peer guides to help Hispanic parents understand and decide about joining cancer treatment trials for their children. It compares this support to standard care to see if it helps more families participate in rese…

This study aims to find out if checking brain injury patients every hour versus every other hour affects their short-term confusion (delirium) and long-term thinking skills. Researchers will enroll 120 adults with a specific type of brain bleed (intracerebral hemorrhage) in the I…

This study aims to understand why people who have both chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea face a much higher risk of heart problems and death. Researchers will compare 240 adults with either condition alone or both together, measuring heart h…

This study aims to understand how meditation affects brain and body connection between therapists and people using opioids. Researchers will measure brain waves, heart rates, and facial expressions during meditation sessions to see if better connection reduces opioid cravings and…