Bladder battle: full or empty to ease radiation side effects?
NCT ID NCT06651697
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 trial tests whether having a full or empty bladder during pelvic radiation therapy reduces short-term side effects like bladder or bowel irritation. 300 adults with pelvic cancers (genitourinary, gynecological, or gastrointestinal) will be randomly assigned to one of the two bladder protocols. The main goal is to see which approach leads to fewer moderate-to-severe side effects within 3 months after treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Radiation therapy with full or empty bladder protocol
What this could lead to
If this trial succeeds, it could show that a simple change in bladder filling during radiation reduces short-term side effects like bladder or bowel irritation.
What could go wrong
This is a Phase 3 trial, but the benefit may be small or not apply to all pelvic cancers. Side effects from radiation itself remain a risk regardless of bladder fullness.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of California, San Diego
RECRUITINGSan Diego, California, 92093, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••