University Of California, San Diego

This study tests whether personalized ventilator settings can reduce lung injury in adults with severe respiratory failure who are on ECMO (a heart-lung machine). Researchers will use esophageal manometry or electrical impedance tomography to tailor the ventilator's positive pres…

This trial investigates whether adding neratinib, a drug that blocks HER2/3/4 proteins, to standard hormone therapy can improve disease control in people with metastatic ER+/HER2- breast cancer that has stopped responding to first-line endocrine therapy. Participants will receive…

This study tests whether a dietary supplement called nicotinamide riboside (a form of vitamin B3) can be safely taken by adults with moderate chronic kidney disease. The main goal is to see if it's feasible for participants to take the supplement daily and complete study procedur…

This study tests a program that combines executive function training (like planning and problem-solving) with cognitive behavioral social skills training for adults aged 60 and older who have schizophrenia or schizoaffective disorder. Participants attend 42 sessions that teach pr…

This study tests a drug called seladelpar in 10 adults who have bile duct damage (ischemic cholangiopathy) after a liver transplant. The goal is to see if the drug can improve liver enzyme levels and is safe. Participants will take the drug for 26 weeks and be monitored closely.

This study tests whether drugs chosen to match specific DNA mutations in a patient's tumor can delay cancer worsening better than standard treatments. About 280 adults with metastatic or unresectable solid cancers will be randomly assigned to receive either DNA-matched therapy or…

This study tests whether combining ketamine-assisted psychotherapy with mindfulness training (called KetaMORE) helps people with opioid use disorder who are already on medication. 88 participants will be randomly assigned to receive either KetaMORE or ketamine with a support grou…

This study will test whether giving primary care doctors easy-to-read reports from patients' Fitbits helps them counsel patients with high blood pressure to be more active. About 330 patients and their doctors will take part. The goal is to see if this simple, low-cost approach c…

This early-stage study tests whether adding specially-made viruses (phages) to standard antibiotics can safely treat stubborn lung infections in adults with cystic fibrosis. About 30 participants will receive a 7-day course of both treatments. The main goal is to check safety, bu…

This study tests if the antibiotic trimethoprim can safely lower folate levels in men starting hormone therapy for advanced prostate cancer. About 50 men will take the drug daily for 3 months to see if it helps control the disease. The goal is to find a safer, more effective way …

This study tests whether wearing a continuous ketone monitor alongside a glucose monitor can reduce the risk of diabetic ketoacidosis (a serious side effect) when taking the drug sotagliflozin. About 52 adults with type 1 diabetes will take low and high doses of sotagliflozin whi…

This study tests a mobile app called LOTUS designed to help people who use drugs engage with HIV prevention services like testing and PrEP. The app provides tips, reminders, peer support, and a way to ask healthcare professionals questions. The trial will enroll 40 participants t…

This study looks at whether a program called Safe Night Out, which trains bar staff to spot and stop sexual and intimate partner violence, actually works. Researchers will enroll 150 staff and 500 patrons from 50 bars in California. Half the bars use the program, half do not. Par…

This study tests two smartphone tools to help HIV-negative men who have sex with men take their daily HIV prevention pill (PrEP) regularly and reduce methamphetamine use. One hundred men with mild to moderate meth use disorder will use the apps for 6 months. Researchers will chec…

This study tests a new group program designed for young people at clinical high risk for psychosis who also have suicidal thoughts or behaviors. The program, led by a clinician and a peer with lived experience, focuses on building hope, setting recovery goals, and strengthening s…

This study tests whether short virtual reality sessions can reduce burnout and increase self-compassion in healthcare workers. 52 participants will either use a VR headset or read a booklet with compassion-focused exercises over 4-6 weeks. The goal is to see if VR is a practical …

This study tests whether a non-invasive brain training technique called gamma EEG neurofeedback can improve working memory in adults with schizophrenia or schizoaffective disorder. About 104 participants will be randomly assigned to receive either real neurofeedback (learning to …

This study tests whether the supplement coenzyme Q10 can ease symptoms like fatigue and pain in people affected by the 2023 East Palestine, Ohio train derailment. Twenty participants will take either CoQ10 or a placebo for three months, then switch. The goal is not to prove benef…

This study looks at how much of the antibiotic vancomycin gets into the blood when it is given through the bone before knee replacement surgery. Thirty adults having their first knee replacement will receive the antibiotic through a needle in the bone, and blood samples will be t…

This study looks at better ways to screen for HPV and prevent cervical cancer in women living with HIV. Researchers will test a new method that identifies specific HPV types and viral load. The goal is to see if this approach is practical for a larger future study. About 750 wome…

This study will test two new services at a large Chicago health center: routine substance use screening for all patients, and a program that asks people to refer friends or partners who might need HIV or addiction care. The goal is to find more people with undiagnosed HIV or subs…