University Of California, San Diego

This early-stage study tests whether adding special viruses (called phages) to standard antibiotics can safely treat hard-to-kill lung infections in adults with cystic fibrosis. About 30 participants will receive a 7-day course of both treatments. The main goal is to check safety…

This study tests if taking trimethoprim, a common antibiotic, daily for 3 months can safely lower folate levels in men starting hormone therapy for advanced prostate cancer. About 50 men will participate. The goal is to see if this approach is safe and might improve treatment out…

This study tests whether wearing a continuous ketone monitor alongside a continuous glucose monitor can reduce the risk of a serious side effect (high ketones) from the drug sotagliflozin in people with type 1 diabetes. About 52 adults will take two different doses of the drug wh…

This study tests a drug called seladelpar in 10 adults who have developed bile duct damage (ischemic cholangiopathy) after a liver transplant. The goal is to see if the drug can lower certain liver enzymes and improve bile flow. Participants will take the drug for 26 weeks, and r…

This study compares two different lengths of hormone therapy (6 months vs. 18 months) combined with radiation for men with high-risk prostate cancer. The goal is to see if the shorter treatment works just as well at preventing cancer from coming back, while potentially reducing s…

This study aims to help primary care doctors use data from wearable fitness trackers to counsel patients with high blood pressure. Researchers will create easy-to-read activity reports and guides for doctors. The study will involve 330 patients and their doctors at UC San Diego H…

This study tests whether drugs chosen based on a patient's tumor DNA mutations can delay cancer growth longer than standard treatments. About 280 adults with metastatic or unresectable solid cancers will be randomly assigned to either personalized drugs or usual care. Participant…

This study tests whether adding mindfulness training to ketamine-assisted therapy helps people with opioid use disorder who are already on medication. About 88 adults will be randomly assigned to receive either the combined treatment or ketamine therapy with a support group. Rese…

This study tests two smartphone tools to help HIV-negative men who have sex with men stick to their daily PrEP medication and reduce methamphetamine use. One app supports PrEP adherence, the other provides cognitive-behavioral therapy for substance use. The study will enroll 100 …

This study tests whether a program called Safe Night Out, which trains bar staff to spot and prevent violence, actually works. Researchers will follow 150 staff and 500 patrons from 50 bars in California for 18 months, comparing bars that use the program to those that don't. The …

This study will test whether a therapeutic ketogenic diet (high-fat, low-carb) can safely reduce eating disorder thoughts and behaviors in people with anorexia nervosa. About 120 participants aged 16 to 45 in a partial hospital program will either follow the ketogenic diet or rec…

This study tests whether the nutritional supplement coenzyme Q10 can reduce symptoms and improve quality of life in people affected by the 2023 East Palestine, Ohio train derailment. Twenty adults who lived near the derailment and have ongoing health issues will take CoQ10 or a p…

This study will test a psychological treatment for chronic pain that is adapted to the culture of American Indian and Alaska Native peoples. About 30 adults with chronic pain will take part to see if the program is acceptable and practical. The goal is to gather information neede…

This study tests whether a chatbot can help first-time mothers learn about pelvic floor health and feel less lonely after childbirth. About 130 new moms will be randomly assigned to either standard care or standard care plus a 4-week chatbot. Researchers will compare knowledge, l…

This study will test two new services at a Chicago health center: routine substance use screening for all patients, and a program that helps people refer friends or partners who may need HIV or addiction care. The goal is to find more people with undiagnosed HIV or substance use …

This study looks at how to best screen for HPV and prevent cervical cancer in women living with HIV. Researchers will test a new method that checks for more types of HPV and measures the amount of virus. The goal is to see if this approach is practical for a larger future study. …