University Of California, San Diego

This study is testing whether a combination of two drugs, sotagliflozin and volagidemab, can improve blood sugar control in adults with type 1 diabetes. The 24 participants will receive both drugs or a placebo in a crossover design. The goal is to see if this approach can help ma…

This study tests whether time-restricted eating (eating all meals within an 8-10 hour window each day) can help people with type 2 diabetes better control their blood sugar and improve heart health. About 60 adults with type 2 diabetes will either follow their usual care or add t…

This study tests a program called REAL Fathers in Uganda, where respected community men mentor young fathers (ages 16-25) on positive parenting, conflict resolution, and family planning. Over 4,700 participants are involved. The goal is to see if this approach reduces intimate pa…

This study tests a telehealth program for Latino families with children aged 5 to 12 who have overweight or obesity. The program helps caregivers support healthy changes, and is compared to standard health education. The goal is to see if this approach improves children's weight …

This study tests whether limiting food intake to a 10-hour window each day helps obese adults lose weight and improve body composition. Sixty-one participants will either follow this eating pattern plus nutritional counseling, or just receive counseling alone. The goal is to see …

This phase 2 trial tests whether giving targeted radiation along with two immunotherapy drugs (evorpacept and pembrolizumab) before standard surgery can improve outcomes for people with HPV-related throat cancer. The study enrolls 29 patients with early-stage, resectable disease.…

This study tests a telehealth program that teaches parents of children with autism and overweight or obesity how to help their child manage weight through nutrition, activity, and behavior skills. About 140 families will take part, with one group receiving the parent-based progra…

This study tests a program called ROC+ to help people who are very responsive to food cues lose weight. It compares ROC+ to standard behavioral weight loss programs in 300 adults with overweight or obesity. The goal is to see if reducing reactions to food cues leads to lasting we…

This study tests a program where trained peers use motivational interviewing to encourage people who use drugs to check their drugs for dangerous substances and adopt safer use behaviors. The goal is to reduce fatal and non-fatal overdoses, as well as HIV and hepatitis C infectio…

This study tests a new approach for people with depression that hasn't responded to medication. It combines an FDA-approved brain stimulation technique called rTMS with digital mindfulness exercises. The goal is to see if this combination can improve both mood and cognitive funct…

This study tests a custom-made drug called an antisense oligonucleotide in a single person with TUBB4A-related leukodystrophy, a rare genetic disorder that affects the brain's white matter. The drug is designed to target the specific genetic mutation causing the disease. Research…

This early-phase study tests whether giving rituximab and high-dose steroids before venetoclax can safely shrink tumors in people with relapsed chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The goal is to lower the risk of tumor lysis syndrome, a serious…

This phase 2 trial tests whether taking the drug axitinib for 8 weeks before surgery can shrink kidney tumors in people with clear cell renal cell carcinoma. The goal is to make partial nephrectomy (removing only the tumor) possible for patients whose tumors are too complex for t…

This phase 2 trial tests whether adding cirmtuzumab to venetoclax can clear remaining leukemia cells in people with chronic lymphocytic leukemia (CLL) who still have detectable disease after standard treatment. Only 5 participants are enrolled, and the main goal is to see if the …

This study is testing a new portable device called LiverScope that uses MRI-like technology to measure fat in the liver. Researchers will compare it to standard MRI and FibroScan in 50 adults with known or suspected non-alcoholic fatty liver disease (NAFLD). Participants undergo …

This study compares two mailed stool tests—Cologuard and FIT—for colorectal cancer screening in adults aged 45-49 who are not up to date with screening. Researchers will measure how many people complete screening and follow up on abnormal results. The goal is to find the most eff…

This study tests a 12-week digitally delivered exercise program called Strong Foundations for adults aged 60 and older. Participants join live small-group classes online to improve strength and balance. The goal is to see if this approach can reduce falls and improve physical fun…

This study tests a 12-week digital exercise program designed to reduce fall risk in older adults. Participants, aged 60 and older, will do guided exercises at home via video calls with expert instructors. The goal is to see if the program improves balance, strength, and posture, …

This study is testing a program called Close to Home that brings communities together to prevent sexual violence. Researchers will compare 9 communities using the program with 9 that are not, tracking about 1,000 people aged 14-24. The goal is to see if strengthening community co…

This study tests whether giving first-time mothers online education about childbirth starting at 30 weeks of pregnancy can lower their risk of post-traumatic stress after delivery. Researchers will enroll 400 women and track their mental health through surveys at 6 weeks and 6 mo…

This study tests a procedure called cryoneurolysis, which uses a small probe to freeze nerves in the foot and block pain signals. It is for adults with painful diabetic neuropathy who have at least moderate pain daily. Thirty participants will be randomly assigned to receive eith…

This study tests a 12-month program to help Latina teenagers become more active. 200 under-active teens will be referred by their doctor. Half get counseling, a website, a Fitbit, texts, and Instagram support; the other half only get a Fitbit. The goal is to see if the full progr…

This study looks at whether strengthening your back muscles before spine surgery can lead to better results, like less pain and faster recovery. About 70 people having spine surgery will take part. Researchers will compare those who do pre-surgery exercises with those who don't t…

This study tests whether a painkiller called suzetrigine can reduce pain after breast surgery (not mastectomy). About 120 adults will take the drug along with a nerve block. Their pain levels will be compared to past patients who had standard care. The goal is to see if this comb…

This study is testing two methods of giving pain medicine through a small tube placed near a nerve after surgery. One method gives a steady, low-dose drip, while the other gives larger doses at set times. The goal is to see which method provides better pain control and lasts long…

This study was designed to test a device called RELAY that delivers both local anesthetic and electrical nerve stimulation through a single catheter after knee surgery. The goal was to provide up to 28 days of pain control, longer than current options. However, the study was with…

This pilot study tested three different strengths of inhaled cannabis (2.5%, 5%, and 10% THC) against a placebo to see if they could quickly relieve migraine headaches. Twenty adults with migraine took part in a crossover design, meaning each person tried all options. The main go…

This pilot study aimed to test a parent-only training program for children aged 8-12 with both ADHD and overweight or obesity. Parents would learn weight management skills and strategies to help their child's focus and planning. However, the study was withdrawn before any partici…

This study looks at whether adding a brief therapy to esketamine nasal spray works better than the spray alone for reducing suicidal thoughts in people with hard-to-treat depression. About 56 adults aged 18 to 70 with ongoing suicidal thoughts will take part. The goal is to see i…

This study tests a computer-based brain-training program called neurofeedback in 112 people with mild cognitive impairment, an early stage of Alzheimer's disease. Participants learn to control their brain activity through visual or audio cues, aiming to improve working memory. Th…

This study tests a device called RELAY that delivers both local anesthetic and mild electrical pulses to nerves after shoulder or foot surgery. The goal is to provide up to 28 days of pain relief, much longer than current options. About 50 adults undergoing specific surgeries wil…

This study tests whether pairing meditation with a brain stimulation technique called rTMS can better treat depression. rTMS is already FDA-approved but only works for about 15-30% of patients. The researchers hope that adding a focus on internal attention (like breathing) during…

This study tests whether temporarily freezing the nerves that supply the breast can reduce pain and the need for opioid painkillers after mastectomy. About 216 women having breast removal will receive either the freezing treatment or a sham procedure. The goal is to see if a sing…

This study tests a one-time nerve-freezing procedure called cryoneurolysis to treat pain from broken ribs. The treatment uses a small probe to freeze the nerves around the fractured ribs, providing pain relief for up to 2-3 months without the side effects or addiction risk of opi…

This study tests whether a continuous nerve block given for 7 days after a leg amputation can prevent phantom limb pain and improve physical and emotional function. About 200 adults scheduled for a lower-limb amputation will receive either a high-concentration numbing medicine or…

This study compares a single injection of liposomal bupivacaine (a long-lasting painkiller) to a continuous nerve block (which uses a pump and catheter) for pain after ankle surgery. Researchers want to see if the single injection works just as well, while being easier and safer.…

This early study tests whether wearing a small nerve-stimulating ear clip at night can safely reduce premature ventricular contractions (PVCs) — extra, often bothersome heartbeats. Sixteen adults with at least 5% PVC burden will use the Parasym device for 10 weeks. The main goals…

This study tests whether cannabidiol (CBD) can reduce severe behavior problems like aggression, self-harm, and repetitive actions in children with autism. About 42 boys aged 7-14 with severe autism and daily behavioral issues will receive both CBD and a placebo at different times…

This early-phase trial is testing whether cannabidiol (CBD) can safely reduce anxiety around mealtimes in people with anorexia nervosa. Forty participants will receive either CBD or a placebo for three weeks. Researchers will track side effects, blood levels of CBD, and changes i…

This pilot study tests whether a ketone drink can help people with anorexia or bulimia by reducing the drive to binge or restrict food. Forty participants will take the drink twice daily for two weeks, and researchers will measure changes in eating behaviors, mood, and brain acti…

This study tests whether a non-invasive brain stimulation technique called TMS can help people with anorexia nervosa. The treatment targets the insula, a brain region involved in taste and body perception. Forty women aged 18-45 with anorexia will receive either real or sham TMS …

This study tests whether offering a blood test (cell free DNA) alongside standard stool tests and colonoscopy increases colorectal cancer screening rates among people who are not up-to-date with screening. The trial enrolls 340 adults aged 45-75 at a health center serving low-inc…

This study aims to validate two new tools that use artificial intelligence to predict a person's risk of developing opioid use disorder. One tool looks at genetic markers, and the other examines gut bacteria. Researchers will enroll 300 adults with or without opioid addiction to …

This study tests whether a two-week plant-based Mediterranean diet can change gut bacteria and reduce inflammation in people who have had colon polyps removed. Thirty participants will eat high-fiber meals delivered to their homes, and researchers will track changes in blood and …

This study looks at why some people with chronic low back pain and disc injuries don't recover fully with exercise. Researchers will measure muscle activity, brain signals, and tissue changes in 152 participants, including those having surgery or starting physical therapy. The go…

This study aimed to understand how blood pressure changes when standing up affect thinking abilities and brain blood flow in people with Parkinson's disease. Researchers planned to compare participants with and without orthostatic hypotension (low blood pressure upon standing) us…

This study tests a program called LIFT to help people who inject drugs in Kyrgyzstan face less stigma and lower their risk of HIV. About 80 participants will join peer-led group sessions to build support and learn how to use HIV prevention services. The goal is to see if the prog…

This study compares two methods of delivering care for urinary incontinence in primary care settings. In one arm, primary care doctors get electronic specialist advice (e-consult). In the other, a nurse practitioner (APP) provides education and self-management coaching via teleme…

This study tests whether a program that trains primary care doctors can improve how they treat women with urinary incontinence. The program includes lectures, checklists, and tools to help doctors provide better care. Researchers will compare clinics that get the training to thos…

This study aimed to understand the link between non-alcoholic fatty liver disease (NAFLD) and psoriatic disease (psoriasis and psoriatic arthritis) in overweight adults. Researchers planned to use the drug guselkumab (Tremfya) to see if it improved both conditions. However, the t…

This study was designed to measure how often urine flows backward from the bladder into the ureter after placing a special stent (RELIEF) in people with kidney stones. Researchers planned to use bladder X-rays to check for reflux and track any symptoms. However, the study was wit…

This study looks at how often nurses should check on people in the ICU after they have had a brain aneurysm treated. The goal is to see if checking every hour versus every two hours affects how well patients sleep. Thirty adults who had a planned aneurysm coiling will take part, …

This study aimed to see if measuring stable carbon and nitrogen isotopes in blood, hair, and fingernails could better track what people eat compared to standard diet surveys. Researchers planned to feed healthy adults controlled meals with different sugar levels and then test the…

This study looks at whether a special type of MRI, called RSI-MRI, can predict how well prostate cancer responds to radiation and hormone therapy. About 100 men with high-risk, localized prostate cancer will get this MRI before and during treatment. The goal is to see if the scan…

This study tests whether a team charter—a simple written agreement that clarifies roles and coordination—can help doctors and staff screen children for depression more consistently and connect them to mental health services faster. Forty healthcare providers at a children's hospi…

This study tests whether adding executive function training to cognitive-behavioral social skills training helps older adults (60+) with schizophrenia learn skills better and improve daily living. About 49 participants will take part. The goal is to see if the combined approach i…

This study gives 300 new mothers a medical-grade smartwatch that tracks blood pressure multiple times daily for 6 weeks after delivery. Researchers want to see if daily blood pressure patterns differ between low-risk, intermediate-risk, and high-risk groups. The goal is to better…

This study looks at how cannabis (marijuana) affects the levels of HIV medications in the blood and brain, as well as mood and thinking. Researchers will give cannabis or a placebo to 40 people with HIV to see if it changes how their drugs work. The goal is to understand if canna…

This study explores whether electroencephalography (EEG), a cheaper and more accessible brain monitoring technique, can reliably measure how the brain processes rewards in adolescents with anorexia nervosa. Researchers will compare EEG results with those from functional MRI (fMRI…

This study uses brain scans to see how negative feelings change food choices and reward processing in people with binge eating disorders. Researchers will compare healthy individuals, those with obesity, and people with binge eating disorder or bulimia. The goal is to understand …