University Of California, San Diego

This study is testing if taking the drug axitinib before surgery can shrink complex kidney tumors, making a kidney-sparing operation possible for patients who otherwise couldn't have it. The goal is to see if this approach is safe and helps surgeons successfully remove tumors whi…

This study aims to improve the quality of care for women with urinary incontinence (bladder leaks) in primary care settings. It will compare two support methods for doctors: one uses electronic specialist advice, and the other uses dedicated nurse practitioners to help manage pat…

This study is testing if combining a meditation-like breathing exercise with a magnetic brain stimulation treatment (rTMS) works better for depression than the stimulation alone. It involves 50 adults with moderate to severe depression who haven't gotten enough relief from antide…

This study is testing a custom-made genetic drug for a single child with a rare, severe brain disorder called TUBB4A-related leukodystrophy. The drug is designed to target the child's specific genetic mutation, with the goal of controlling symptoms like muscle stiffness and impro…

This study is testing whether a non-invasive brain stimulation technique can help people with anorexia nervosa. Researchers will use magnetic pulses to target brain circuits involved in body image and eating behaviors. The goal is to see if this approach is practical and shows pr…

This study is testing whether time-restricted eating (limiting all food intake to a 10-hour window each day) helps obese adults lose weight and improve how their body fat responds to natural weight-loss signals. Researchers will compare this approach to standard nutritional couns…

This study is testing whether adding a new drug called cirmtuzumab to existing venetoclax treatment can help eliminate remaining cancer cells in people with chronic lymphocytic leukemia. The trial involves patients who have been on venetoclax for at least a year but still show de…

This study aims to identify which Alzheimer's patients are most likely to benefit from the approved medication memantine. Researchers will test whether a simple brain function measurement after a single dose can predict who will show the best cognitive improvement over six months…

This study is testing whether combining two types of therapy can help older adults with schizophrenia improve their daily functioning. The program blends cognitive-behavioral social skills training with computerized brain exercises designed to boost thinking skills. Researchers a…

This study aimed to test a new parent training program designed to help children who have both ADHD and weight concerns. The program taught parents strategies to improve their child's planning and self-control skills while promoting healthy habits. Researchers wanted to see if th…

This study is testing a new training program for primary care doctors to see if it improves care for women with urinary incontinence (bladder leaks). About 1,600 women from diverse backgrounds will participate. The goal is to help doctors provide better, evidence-based treatment …

This study is testing whether eating a specific high-fiber, plant-based Mediterranean diet for two weeks after a colonoscopy can improve gut health. Researchers will enroll 30 people with a history of colon polyps to see if the diet reduces inflammation, changes gut bacteria, and…

This study is testing a new order for giving approved cancer drugs. The goal is to see if giving two drugs first can safely shrink the amount of cancer in the body. This could make it safer to start a third, powerful drug by lowering the risk of a dangerous side effect called tum…

This study is testing if wearing a small electrical ear clip device for six hours each night can safely help reduce extra heartbeats called premature ventricular complexes (PVCs). Sixteen adults with a significant PVC burden will try both a real and a fake version of the device f…

This study is testing a computer-based brain-training program designed to improve working memory in people with mild cognitive impairment, an early stage of Alzheimer's disease. Participants will complete brain-training sessions twice a week for 12 weeks while researchers measure…

This study is testing a new portable device called LiverScope® to see if it can accurately measure fat in the liver. Researchers are comparing it to standard MRI scans and another ultrasound test in 50 adults with or suspected of having fatty liver disease. The goal is to see if …

This study compares two different stool test kits mailed to people's homes to see which one gets more adults aged 45-49 to complete colon cancer screening. Researchers will send either the Cologuard test or the FIT test to 400 participants who aren't up-to-date with their screeni…

This study is testing if a peer counseling program can help people who use drugs check their drugs for dangerous substances and adopt safer habits to prevent overdoses. It will involve 588 adults in San Diego who use opioids or methamphetamine. The goal is to see if this support …

This study is testing a year-long program to help Latina teenagers who aren't very active get more exercise. Researchers will work with 200 teens, half of whom will get a personalized plan with a counseling session, a Fitbit, text reminders, and a special website. The other half …

This study is testing whether a community-led program called 'Close to Home' can prevent sexual violence. It will compare 18 California communities, some running the program and some not, to see if the program changes social attitudes and reduces violence. The research involves a…

This study is testing a 12-week online exercise program designed to prevent falls in older adults. Researchers are enrolling about 92 participants, focusing on those at higher risk of falling and from lower-income backgrounds. The program uses video calls with small-group, person…

This pilot study aims to find out if mailing a Cologuard test kit or a simpler FIT test kit is more effective at getting people to complete colon cancer screening. It involves 100 adults aged 45-49 who are not up-to-date with their screening. Researchers will measure how many peo…

This study is testing whether watching educational videos about common labor experiences during pregnancy can help prevent traumatic stress symptoms after childbirth. Researchers are enrolling 400 first-time mothers to compare those who receive the video education with those who …

This study is testing if a 7-day continuous nerve block after leg amputation can prevent chronic phantom limb pain, improve mobility, and reduce the need for opioid painkillers. It involves 203 participants who are randomly assigned to receive either a strong numbing medicine or …

This study is testing whether a combination treatment works better than medication alone for quickly reducing suicidal thoughts. Researchers are comparing a nasal spray medication (esketamine) plus a brief talk therapy to the nasal spray by itself. They are enrolling adults aged …

This study is testing a new device called RELAY that aims to better control pain after shoulder or foot surgery. It combines a local anesthetic injection with a small electrical current delivered through the same tiny tube for up to 28 days. Researchers are comparing the device's…

This study aimed to test a new device called RELAY for managing pain after knee surgery. The device is a single catheter placed near a nerve that can first deliver numbing medicine and then provide weeks of pain relief using gentle electrical stimulation. The goal was to see if t…

This study is testing two different ways to deliver numbing medicine through a small tube placed near nerves after arm or leg surgery. Researchers want to see if a newer method, where the pump gives automatic, adjustable doses, works as well for pain and lasts longer than the sta…

This early-stage study is testing whether cannabidiol (CBD) can help reduce the anxiety people with anorexia often feel around meals. Researchers will give CBD to 40 participants to check for side effects, see how their bodies process it, and measure any changes in eating disorde…

This small pilot study is testing whether inhaling cannabis can quickly stop migraine pain and other symptoms like light sensitivity. Twenty adults with migraines will try three different strengths of cannabis and a placebo during separate attacks to see which works best. The goa…

This study is testing whether a purified form of CBD, a compound from the cannabis plant, can help reduce severe behavior problems in children with autism. Researchers are enrolling 30 boys, aged 7-14, who struggle with daily aggression, self-harm, or extreme hyperactivity. Each …

This study is testing a procedure called cryoneurolysis, which uses extreme cold to temporarily freeze nerves, to see if it can provide months of pain relief for people with broken ribs. The goal is to offer a single, non-addictive treatment that could reduce the need for opioid …

This study is comparing two ways to manage pain after ankle surgery. Researchers want to see if a single, long-acting numbing shot works as well as a multi-day nerve block pump. The goal is to find a simpler, less burdensome method that controls pain and reduces the need for opio…

This small pilot study is testing whether a ketone supplement drink can help people with anorexia or bulimia. Researchers want to see if the drink reduces the urge to binge eat or restrict food, and improves mood and anxiety. Participants will try the drink or a placebo while hav…

This study is testing if temporarily freezing specific nerves near the ribs can provide long-lasting pain relief after breast removal surgery (mastectomy). The goal is to see if this single, non-addictive procedure can reduce both short-term pain and the need for opioid painkille…

This study aims to understand how using cannabis affects the levels of HIV medications in the body and brain, and whether it impacts mood and thinking. Researchers will first observe 120 people who already use cannabis, then give cannabis or a placebo to 40 people to measure imme…

This study aims to better understand blood pressure changes in the 6 weeks after childbirth. Researchers will give 300 new mothers a special smartwatch that continuously monitors blood pressure to see how patterns differ between low-risk, medium-risk, and high-risk women. The goa…

This study aims to understand how negative emotions like stress or sadness affect the brain's reward system and food choices in people with binge eating disorders and obesity. Researchers will use brain scans (fMRI) to compare brain activity in four groups of adults: those with b…

This study aimed to check if a new type of ureteral stent, placed after kidney stone procedures, causes urine to flow backward from the bladder. Researchers planned to use imaging to grade this backflow in adult patients with kidney stones. The trial was withdrawn before any part…

This study aims to develop a simpler, more accessible brain scan method (EEG) to understand how the brain processes rewards and surprises in adolescents with anorexia nervosa. Researchers will test 47 female teens, comparing those with anorexia to healthy peers, to see if EEG can…

This study aimed to understand if there is a connection between non-alcoholic fatty liver disease (NAFLD) and active psoriatic disease (skin/joint inflammation). Researchers wanted to see if a medication called Guselkumab, already approved for psoriasis, could also improve fatty …

This study aimed to test a new way to measure what people eat by analyzing tiny natural markers in blood, hair, and fingernails. Researchers wanted to see if these markers were more accurate than traditional food surveys. The goal was to improve diet tracking to help prevent hear…

This study is testing a new team-based strategy to improve how a large children's hospital screens for depression. It involves 40 doctors and staff members. The goal is to make the screening process smoother and faster so children who need help get connected to mental health serv…

This study is testing whether a special type of MRI scan can predict how well treatment will work for men with high-risk prostate cancer. One hundred men who are scheduled to receive standard radiation and hormone therapy will get this advanced scan before, during, and after trea…

This study aims to understand if checking brain function every hour versus every two hours affects sleep quality for patients in the intensive care unit (ICU). Researchers are observing 30 adults who had a procedure to treat a brain aneurysm. They will measure sleep using brain w…