Nerve block breakthrough: could a 7-Day treatment stop phantom limb pain?

NCT ID NCT03461120

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 28 times

Summary

This study tests whether a continuous nerve block given for 7 days after a leg amputation can prevent phantom limb pain and reduce the need for opioids. About 200 adults scheduled for a lower-leg amputation will receive either a numbing medicine or a placebo through a tiny tube placed near the nerve. The goal is to improve physical and emotional function after surgery.

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Contacts and locations

Locations

  • Boston VA

    Boston, Massachusetts, 02130, United States

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Fairview Hospital

    Cleveland, Ohio, 44111, United States

  • Mass. General Hospital

    Boston, Massachusetts, 02114, United States

  • Naval Medical Center San Diego

    San Diego, California, 92134, United States

  • University California San Diego

    San Diego, California, 92103, United States

  • University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

Conditions

Explore the condition pages connected to this study.