Freezing chest nerves could slash opioid use after mastectomy

NCT ID NCT05444361

ENROLLING_BY_INVITATION Symptom relief Sponsor: University of California, San Diego Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 12, 2026 · Updated 24 times

Summary

This study tests a one-time, non-drug treatment called cryoneurolysis that freezes the nerves in the chest to block pain after mastectomy (breast removal). The goal is to see if it reduces pain and the need for opioid painkillers for two months after surgery. About 216 adults having mastectomy will receive either the real freezing or a sham procedure. If it works, it could offer a safer, non-addictive way to manage post-surgery pain.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Cedars-Sinai

Los Angeles, California, 90048, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
University of California San Diego

San Diego, California, 92103, United States
University of Florida

Gainesville, Florida, 32607, United States
Walter Reed National Military Medical Center

Bethesda, Maryland, 20889, United States

Conditions

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MASTECTOMY; LYMPHEDEMA