Drug shrinks kidney tumors, may spare patients from full organ removal

NCT ID NCT03438708

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 23 times

Summary

This study tested the drug axitinib in 22 people with a type of kidney cancer (clear cell renal cell carcinoma) who needed surgery but had complex tumors that made it hard to remove only the cancerous part. The goal was to see if taking axitinib before surgery could shrink the tumor enough to allow a partial nephrectomy (removing just the tumor) instead of removing the whole kidney. The study measured tumor shrinkage, changes in tumor complexity, and how many surgeries were successful.

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Contacts and locations

Locations

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • UC San Diego Moores Cancer Center

    La Jolla, California, 92093, United States

Conditions

Explore the condition pages connected to this study.