DEPRESSIVE DISORDER

This study will check if an artificial intelligence (AI) system can diagnose depression as accurately as a psychiatrist. About 100 adults with depression will take part. Their AI-based diagnosis will be compared to the diagnosis made by a mental health specialist.

This trial is testing whether a specially adapted form of cognitive behavioral therapy, called CBT-DAY, can reduce depressive symptoms in autistic youth aged 11 to 17. Participants will be randomly assigned to receive either CBT-DAY or standard care, and researchers will compare …

This study looks at whether combining group cardiovascular exercise with group therapy can help reduce symptoms of anxiety and depression in adults living in rural areas. Twenty participants with generalized anxiety or depressive disorders will take part in a structured program. …

This study tests whether a small device that gently stimulates a nerve in the ear can help reduce depression in people with Parkinson's disease. Participants use the device at home twice a day for 14 days. The trial measures changes in mood and brain activity to see if this simpl…

This study tests a program called Natural Psychotherapy to see if it can reduce anxiety and depression symptoms in 3,000 Chinese students aged 7 to 18. Participants will be randomly assigned to the program or a control group, and their progress will be tracked for 6 months. The g…

This study tests whether using a personalized medicine clinic to tailor antidepressant doses can improve depressive symptoms. Researchers will enroll 200 adults with depression and track changes using a standard depression survey. The goal is to see if customizing medication base…

This study tests whether a probiotic called Bifidobacterium PB-18 can improve symptoms of mild to moderate depression in adults aged 18 to 65 who are not taking antidepressants. Participants will take either the probiotic or a placebo daily for 8 weeks. Researchers will measure d…

This study tests a type of brain stimulation called theta burst stimulation (TBS) for people with depression that hasn't improved with medication. About 120 adults and teens will either get real TBS or a fake version first, then real TBS later. Researchers will measure changes in…

This study will test a one-day acceptance and commitment therapy (ACT) program for 50 veterans who have both inflammatory bowel disease (IBD) and a mental health condition like depression, anxiety, or PTSD. The goal is to see if this brief therapy can improve their quality of lif…

This study tests a non-invasive brain stimulation technique called iTBS to help ease depression in young women aged 16 to 24. Eight female participants will receive the treatment to see if it improves mood and brain function. The goal is to find a new way to reduce depression sym…

This study compares two add-on treatments—esketamine nasal spray and aripiprazole pills—for older adults (60-74) whose depression hasn't improved with standard antidepressants. Around 220 participants will receive either esketamine once or twice weekly or daily aripiprazole, alon…

This study explores how financial insecurity—such as trouble paying for housing, food, or healthcare—affects the mental health of university students and whether it keeps them from seeking help. Researchers will conduct in-depth interviews with 30 students from two French univers…

This study looks at whether low magnesium levels are linked to sleep problems in people with major depressive disorder. Researchers will measure magnesium in the blood of 90 adults and compare it to their sleep quality. The goal is to better understand this possible connection, n…