DEPRESSIVE DISORDER

This study tests a brief group therapy called Resilience Training for Teens. It aims to prevent serious mental illness in high school students aged 14-19 who have mild symptoms of depression, anxiety, or unusual feelings. About 70 teens will participate to see if the training hel…

This study looks at whether cognitive-behavioral therapy, exercise training, or both can lower the risk of type 2 diabetes in teenage girls. Participants are 300 girls aged 12-17 who are at higher risk due to family history, weight, and mood symptoms. The goal is to see if these …

This study looks at whether nicotine patches can help older adults (60+) with depression who are already on antidepressants. The goal is to see if nicotine improves mood and thinking skills by boosting brain control networks. Sixty participants will receive either a nicotine patc…

This pilot study compares two schedules of repetitive transcranial magnetic stimulation (rTMS) in 42 adults with depression and long COVID. One group gets one session daily for six weeks; the other gets six sessions daily for five days. Researchers will measure changes in depress…

This study is testing a therapy program called Unified Protocol for children and teens (ages 7-17) with anxiety or depression, along with their parents. The program uses cognitive-behavioral techniques to help manage emotions. Researchers will measure changes in symptoms and pare…

This study looks at three ways to treat moderate depression in adults aged 18-65: usual care from a family doctor, therapy from a psychologist, or a structured step-by-step treatment plan from a doctor. The goal is to see which approach works best. About 171 people will take part…

This study tests whether a non-invasive brain stimulation technique called temporal interference stimulation (TIS) can improve memory and mood in people with depression. Sixty adults aged 18 to 65 with moderate to severe depression will receive TIS while their memory and depressi…

This study is for people with depression that hasn't improved with medication. It combines a type of brain stimulation called iTBS with digital mindfulness training to help improve mood and thinking. The goal is to see if this combination works better than brain stimulation alone…

This study tests a new therapy called EL-SHIN THERAPY to see if it can help reduce symptoms of depression, anxiety, and stress. About 80 adults with moderate depression, anxiety, and stress will take part. The therapy is added to their usual care, and researchers will measure moo…

This study aims to improve depression care in Indian primary care settings. It will involve 1,500 adults with moderate to severe depression, who will receive either a type of talk therapy (Healthy Activity Program) or antidepressant medication (fluoxetine). The goal is to see if …

This study tests a new drug called (2R,6R)-HNK to see if it can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with thei…

This study tests whether taking psilocybin mushrooms (the active ingredient in magic mushrooms) along with the antidepressant fluoxetine (Prozac) is safe and helps reduce depression symptoms. 24 adults with treatment-resistant depression will receive one dose of mushrooms and eit…

This study tests a modified version of dialectical behavior therapy (DBT) for people with anxiety or depressive disorders. Researchers want to see if this therapy improves symptoms, daily function, and quality of life. The study will involve 250 participants at two medical center…

This study tests a 3-session program called Omnis Salutis for recent veterans with PTSD, depression, anxiety, or substance use. The program teaches veterans about whole health and how to communicate their needs to doctors and loved ones. Researchers want to see if it improves soc…

This study tests whether a smartphone app that helps people set personal goals for sleep, diet, exercise, and social connections can reduce depression symptoms. About 216 adults visiting their general practitioner for depression will either use the app alongside their usual care …

This early study tests whether a precise, low-dose radiation treatment (stereotactic radiotherapy) can safely reduce symptoms in people with treatment-resistant depression. Nine adults aged 18-50 who have not responded to at least two antidepressants will receive the procedure an…

This study looks at whether a simple breathing practice is a practical and well-liked option for teenagers aged 12 to 17 who have anxiety or depression. Researchers will work with 40 teens from both rural and non-rural areas to see if they can stick with the program and find it h…

This study looks at whether adding a digital mindfulness program to usual care helps adults aged 18-65 recover from emotional disorders like depression, anxiety, OCD, PTSD, and eating disorders. Participants will attend online group sessions and use a WeChat mini-program for guid…

This study aims to better understand high-level thinking problems—like motivation, self-awareness, and decision-making—in people with mental health or brain disorders such as schizophrenia, depression, bipolar disorder, Alzheimer's, and stroke. Researchers will compare 600 patien…

This study looks at whether a person's mental state—like anxiety or depression—can influence how well immunotherapy works for triple-negative breast cancer. About 120 women will receive standard treatment, complete psychological surveys, and give blood and saliva samples. The goa…

This study talks to 15 children aged 8–12 who have depressive symptoms, and their parents, to learn what everyday stresses they face and how they cope. The goal is to use this information to create a fun app that teaches emotional skills through games. No treatment or medication …

This study looks at how vagus nerve stimulation (VNS) changes the nervous system, heart, immune system, and metabolism in people who already have a VNS device for epilepsy or depression. It is not a treatment study—it aims to learn how VNS works. About 144 adults aged 18 and olde…

This study looks at how a 9-week talk therapy called Engage & Connect changes brain activity in older adults (ages 50-80) who have depression and suicidal thoughts. Researchers will use brain scans to see if the therapy boosts activity in brain areas linked to feeling rewarded by…

This study uses brain scans to see if psilocybin (the active ingredient in magic mushrooms) changes how the brain works in people with depression. Fifty adults will receive either psilocybin or a placebo during two therapy sessions, and have an MRI to measure brain activity and b…

This study looks at gut bacteria and related chemicals in 120 adults to understand why inflammatory bowel disease (IBD) and depression often occur together. Researchers will compare three groups: people with both IBD and depression, people with IBD only, and healthy volunteers. T…

This study is creating a large, standardized research platform to help scientists understand mood disorders like depression and bipolar disorder better. It will enroll 900 people, including those with mood disorders and healthy volunteers, to collect detailed clinical information…