DEPRESSIVE DISORDER

This study tests a new behavioral therapy called OPT-A for teenagers who have both substance use problems and mood or anxiety disorders. 140 teens aged 10-17 will receive either OPT-A or standard treatment. Researchers will track substance use and mental health for 18 months to s…

This study tested a stepped care model for depression in 14 HIV clinics in Malawi. 487 adults with moderate to severe depression received group counseling and, if needed, antidepressant medication. The goal was to see if this approach could reduce depression symptoms and improve …

This study tested whether a daily probiotic drink (like Yakult) can reduce cold symptoms in triathletes before and after a competition. 80 healthy amateur triathletes drank either the probiotic or a placebo for 30 days before and 14 days after a race. Researchers tracked symptoms…

This study tested a program called iDOVE2 for teens at risk of peer violence and mild-to-moderate depression. The program started with a brief session in the emergency department, followed by automated text messages designed to prevent violence and depressive symptoms. Researcher…

This study tested a 6-week program designed to prevent anxiety and depression in American Indian children aged 8-12. The program uses games and role-play to help kids handle stress, and was adapted with input from the tribal community. Researchers worked with 28 children from two…

This study explores whether locally adapted nature-based health interventions can help people with mild to moderate anxiety, depression, or stress. Around 120 adults will take part in weekly outdoor group sessions for at least 10 weeks, focusing on nature interaction, social conn…

This study tested an internet-based cognitive behavioral therapy (CBT) program called AMTE for adolescents with anxiety and depression. Sixty teens were randomly assigned to either the online program or a control group. The goal was to see if the program could reduce symptoms of …

This study tested whether a blend of online and in-person therapy (called blended CBT) works as well as standard face-to-face therapy for adults with major depression. 105 participants were randomly assigned to either blended CBT or usual care. Researchers measured depression sym…

This study tested whether a program called PRISM (Promoting Resilience in Stress Management) could help young adults aged 18-39 who have cancer or desmoid tumors manage anxiety and depression. The program teaches skills like stress management, goal setting, and positive thinking.…

This study tested a new, non-invasive treatment for major depression called transcranial photobiomodulation (tPBM), which uses near-infrared light on the scalp. Fifty adults with depression received either real light therapy or a sham treatment three times a week for six weeks. T…

This study tested an optimized multichannel tDCS (a non-invasive brain stimulation device) against standard and sham versions in 60 adults with moderate-to-severe major depression. The goal was to see if the new protocol better reduces depressive symptoms and improves memory and …

This study looked at whether using a person's DNA to pick an antidepressant works better than usual care for cancer patients with depression or anxiety. About 99 adults with cancer took part. Half got a DNA-guided choice of medication, and the other half got standard care. Resear…

This study tested a non-invasive brain stimulation technique called HD-tACS in 60 adults with depression who had suicidal thoughts. The goal was to see if it could reduce those thoughts and understand how it works in the brain using MRI and EEG scans. The treatment is painless an…

This study tested a non-invasive brain stimulation technique called HD-tDCS on 57 adults with depression. The goal was to see if it could reduce physical symptoms like aches and fatigue, which often accompany depression. Participants received either real or fake stimulation, and …

This study tested a 10-session therapy program delivered by phone or video to help adults with moderate-to-severe depression become more physically active. The goal was to see if the program was practical and liked by participants, and if it could reduce depressive symptoms. 65 a…

This study tested whether ketamine, a fast-acting drug, can reduce suicidal thoughts in teenagers more quickly than standard treatments. Fifty teens aged 13-18 who had recent suicidal events received either ketamine or midazolam twice weekly for two weeks, then were monitored for…

This study tested a short psychological program called Problem Management Plus (PM+) for adults with depression or anxiety in a primary care clinic in Chile. The program involves five 90-minute sessions teaching problem-solving and stress management skills, delivered by healthcar…

This study tested a smartphone app designed to reduce anxiety and depression in people already receiving medication for opioid use disorder. 63 adults were randomly assigned to use the app for four weeks or to continue their usual care. The goal was to see if the app was feasible…

This study tested whether unlimited text-based therapy works as well as weekly video therapy for depression. Over 1,100 adults with depression were randomly assigned to one of the two approaches. Researchers also looked at what treatment options work best for people who don't imp…

This study tested whether taking part in art activities (like painting, music, or dance) can improve mental well-being. 382 people with mental health issues such as anxiety, depression, or emotional disorders were randomly assigned to either an art program or a waitlist. The stud…

This study tested a group version of a therapy program called UP-A for 15 teenagers with severe emotional disorders like anxiety and depression. The teens were treated at a day hospital in Spain. The program aimed to help them manage their emotions and reduce symptoms. Researcher…

This study tested a group version of a therapy program called the Unified Protocol for teens with emotional disorders like anxiety and depression. Thirty-one adolescents took part in 16 weekly group sessions at a public mental health center in Spain, along with three parent sessi…

This study looked at 15 people with depression who experienced temporary dissociative states (feeling disconnected from reality) while taking Esketamine. Researchers used interviews to understand these experiences better. The goal is to learn more about this side effect to improv…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study tested a new digital tool called CBTpro that uses artificial intelligence to help therapists improve their skills in cognitive behavioral therapy for psychosis (CBTp). Over 600 participants, including therapists and their clients with conditions like schizophrenia or b…

This study looked at 300 people to see if depression causes changes in blood cells that show signs of early aging and stress. Researchers measured telomere length and oxidative stress levels to find genetic markers that could help doctors understand how severe a person's depressi…

This study looked at how young people feel about learning about depression through Instagram. Researchers showed 18 teens the 'ich bin alles' Instagram channel and asked about their thoughts and feelings. The goal was to understand if social media can be a good way to share menta…

This completed study followed 1,290 adults with type 1 or type 2 diabetes for two years. Researchers tracked mental health issues like depression, anxiety, and eating problems alongside daily blood sugar levels using smartphone surveys and continuous glucose monitors. The goal wa…

This study tested whether an Instagram channel called 'ich bin alles' could help teenagers learn about depression and reduce stigma. 170 teens who already used Instagram took part. The goal was to see if social media can be a good way to share mental health information and encour…

This study looked at how the COVID-19 pandemic impacted the mental health of 501 nursing home workers in Occitanie, France. Researchers measured rates of post-traumatic stress disorder (PTSD), depression, and burnout using standard questionnaires. The goal was to understand how c…

This study tested a system where police officers can call a mental health provider during encounters with people who have serious mental illness. The goal was to see if this reduces arrests and helps people stay connected to care. Over 1,400 participants were randomly assigned to…