Could a better tDCS protocol lift depression?

NCT ID NCT06165445

Completed Symptom relief Sponsor: The National Brain Mapping Laboratory (NBML) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested an optimized multichannel tDCS (a non-invasive brain stimulation device) against standard and sham versions in 60 adults with moderate-to-severe major depression. The goal was to see if the new protocol better reduces depressive symptoms and improves memory and attention. The trial is complete, and results may guide future depression treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: transcranial direct current stimulation (tDCS)
What this could lead to: If successful, this could lead to a more effective, non-invasive brain stimulation protocol for easing depression symptoms and improving thinking skills.
What could go wrong: This is a small, completed trial with 60 participants. The results may not apply to everyone, and the benefits over existing treatments are uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction depressive disorder major depressive disorder psychiatric disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COGNITIVE IMPAIRMENT DEPRESSIVE DISORDER PSYCHIATRIC DISORDER

Contacts and locations

Locations

Zanjan University of Medical Sciences

Zanjan, Zanjan Province, Iran

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