Magic mushrooms take on depression: new trial tests psilocybin with antidepressants
NCT ID NCT06898606
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a single dose of psilocybin mushrooms, combined with therapy, can help adults with treatment-resistant depression. Half of the 24 participants will also take the antidepressant fluoxetine to see if it changes the effects. The main goal is to measure mood improvement after 4 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Psilocybin (from Psilocybe cubensis mushrooms)
What this could lead to
If it works, this could point toward a new treatment option for people with depression that hasn't improved with standard medications.
What could go wrong
This is a small, early-phase trial with only 24 participants, so results may not apply to everyone. The psychedelic experience can be intense and may cause temporary distress.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for DEPRESSIVE DISORDER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Federal University of Latin American Integration
RECRUITINGFoz do Iguaçu, Paraná, 85870-650, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••