New hope for epilepsy: Real-World data on Cenobamate's impact

NCT ID NCT05859854

Ongoing Disease control Sponsor: Aziende Chimiche Riunite Angelini Francesco S.p.A Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looks at how well the drug cenobamate works for adults with focal seizures that don't improve with at least two other epilepsy medicines. Researchers are collecting data from Italian clinics and a compassionate use program to measure seizure reduction and side effects. About 936 participants are being followed to see if cenobamate can safely lower seizure frequency in real-world settings.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cenobamate
What this could lead to: If successful, this study could confirm that cenobamate helps reduce seizure frequency in adults with hard-to-control focal epilepsy.
What could go wrong: This is an observational study, not a controlled trial, so results may be less reliable. It also focuses on real-world use, not a new treatment discovery.

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Conditions

The condition(s) this trial relates to.

epilepsy focal epilepsy nervous system disorder visual epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPILEPSY FOCAL ONSET SEIZURE NEUROLOGICAL DISORDER

Contacts and locations

Locations

Associazione La Nostra Famiglia - IRCCS Eugenio Medea

Conegliano, Treviso, 31015, Italy
Azienda Sanitaria Universitaria (A.O.U.) Integrata

Udine, Udine, 33100, Italy
Campus Bio-Medico

Roma, Roma, 00128, Italy
Fondazione Istituto Neurologico Casimiro Mondino

Pavia, Pavia, 27100, Italy
Humanitas Gradenigo

Torino, Torino, 10153, Italy
IRCCS Neuromed

Pozzilli, Isernia, 86077, Italy
Ospedale San Bortolo

Vicenza, Vicenza, 36100, Italy
Policlinico Umberto I

Roma, Roma, 00161, Italy
Policlinico di Bari

Bari, Bari, 70124, Italy
Università degli Studi di Catanzaro "Magna Graecia"

Catanzaro, Catanzaro, 88100, Italy

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