New hope for epilepsy: Real-World data on Cenobamate's impact
NCT ID NCT05859854
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study looks at how well the drug cenobamate works for adults with focal seizures that don't improve with at least two other epilepsy medicines. Researchers are collecting data from Italian clinics and a compassionate use program to measure seizure reduction and side effects. About 936 participants are being followed to see if cenobamate can safely lower seizure frequency in real-world settings.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
cenobamate
What this could lead to
If successful, this study could confirm that cenobamate helps reduce seizure frequency in adults with hard-to-control focal epilepsy.
What could go wrong
This is an observational study, not a controlled trial, so results may be less reliable. It also focuses on real-world use, not a new treatment discovery.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Associazione La Nostra Famiglia - IRCCS Eugenio Medea
Conegliano, Treviso, 31015, Italy
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Azienda Sanitaria Universitaria (A.O.U.) Integrata
Udine, Udine, 33100, Italy
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Campus Bio-Medico
Roma, Roma, 00128, Italy
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Fondazione Istituto Neurologico Casimiro Mondino
Pavia, Pavia, 27100, Italy
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Humanitas Gradenigo
Torino, Torino, 10153, Italy
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IRCCS Neuromed
Pozzilli, Isernia, 86077, Italy
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Ospedale San Bortolo
Vicenza, Vicenza, 36100, Italy
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Policlinico Umberto I
Roma, Roma, 00161, Italy
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Policlinico di Bari
Bari, Bari, 70124, Italy
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Università degli Studi di Catanzaro "Magna Graecia"
Catanzaro, Catanzaro, 88100, Italy