EPILEPSY

This study tested a brain implant (RNS System) that delivers targeted electrical stimulation to the thalamus to reduce seizures in people aged 12 and older with drug-resistant idiopathic generalized epilepsy. The goal was to see if the device is safe and effective at cutting down…

This pilot study tested a non-invasive brain stimulation technique called tDCS in 17 people with drug-resistant epilepsy. The stimulation was personalized using prior brain recordings to target the exact area causing seizures. The goal was to see if this approach could safely red…

This study tested whether taking coenzyme Q10, a natural supplement, can help reduce seizures in adults with drug-resistant epilepsy. Thirty-nine participants took either coenzyme Q10 or a placebo daily for 12 weeks alongside their usual seizure medications. Researchers tracked s…

This study tested whether adding lacosamide (Vimpat) to a low dose of levetiracetam works better than a high dose of levetiracetam alone for controlling seizures. Fifty-six adults with epilepsy who had seizures on low-dose levetiracetam took part. The main goal was to see how man…

This study followed 345 people with epilepsy who already had a brain implant called the RNS System. The goal was to see how safe and effective the device is over 5 years in everyday medical practice. Researchers measured side effects, seizure reduction, and how well doctors could…

This study tested whether training community health workers to manage childhood epilepsy can help the many children in Africa who go untreated. Over 1,600 children in Nigeria received either care from trained health workers or standard doctor care. The goal was to see if the comm…

This study tested the drug levetiracetam in 137 elderly patients (age 60+) with epilepsy. Researchers measured how many stayed seizure-free, how long until the next seizure, and how well patients tolerated the medication. The goal was to see if this drug is effective and safe for…

This pilot trial tested whether taking oral zinc every day for 6 months is safe and doable for people with GNAO1 disorders, a rare genetic condition that causes movement problems, seizures, and developmental delays. 13 participants aged 6 months to 30 years took zinc acetate. The…

This study tested a smartphone-based system to help children with epilepsy take their anti-seizure medication as prescribed. The system included educational information, automated reminders, and personalized feedback. The goal was to improve medication adherence, reduce seizures,…

This study looked at the long-term safety of brivaracetam, a seizure medication, when added to existing treatment in 257 children with epilepsy. The main goal was to track side effects over time. Researchers also measured how well the drug controlled seizures. The results help do…

This Phase 3 trial tested whether adding brivaracetam (Briviact) to existing epilepsy medications could safely reduce partial seizures in adults aged 16 to 80. About 449 participants who still had frequent seizures despite taking 1 or 2 other drugs were randomly assigned to recei…

This study tested whether a single dose of naloxone, given right after a generalized tonic-clonic seizure, can help people with epilepsy breathe better and avoid sudden death. Researchers enrolled 485 adults with drug-resistant epilepsy who were already in the hospital for monito…

This completed study compared two oral seizure medications, brivaracetam and levetiracetam, as first treatments in 102 children aged 1 month to 14 years with newly diagnosed epilepsy. Researchers looked at how well each drug stopped seizures and what side effects occurred. The go…

This study tested a system called Nelli that uses cameras and artificial intelligence to detect seizures in children without needing the usual brain-wave sensors. The system was compared to standard video-EEG monitoring in 150 children aged 6 to 21 who were already being monitore…

This completed study tested a high-density EEG (using up to 256 electrodes) to map brain areas involved in movement, sensation, language, and emotion. It included 122 people with epilepsy, brain tumors, or healthy controls. The goal was to see if this technique can more precisely…

This study tested a simplified brain wave test (point-of-care EEG) on 200 children with confusion or ongoing seizures in the pediatric emergency department. The quick EEG uses just five stickers on the scalp. Researchers compared it to the standard full EEG to see if it can relia…

This study tested a special light helmet (called tPBM) on 6 autistic children aged 4–12 who also had abnormal brain activity or epilepsy. The helmet delivered near-infrared light to specific brain areas twice a week for 10 weeks. The goal was to see if it could safely improve foc…

This small study tested whether a single dose of Staccato Alprazolam (a fast-acting form of a common anxiety drug) could reduce seizure-related brain activity in people with photosensitive epilepsy. Five adults with a history of light-triggered brain responses took the drug or a …

This study tested whether coloring mandalas (circular patterns) at home can improve quality of life for adults with epilepsy. 70 participants were split into two groups: one colored mandalas three times a week for two months, the other did not. Researchers measured changes in qua…

This study looked at using a heat-based technique called thermocoagulation in 100 children aged 1.5 to 17 years with focal epilepsy that doesn't respond to medication. During a brain monitoring procedure, doctors applied small heat lesions to the area where seizures start, aiming…

This pilot study tested a device called NaviFUS that uses focused ultrasound to stimulate the brain in 12 adults with drug-resistant epilepsy. The goal was to see if it is safe and can reduce seizure frequency. Participants kept seizure diaries and reported any side effects over …

This study tested a device that sends a very mild electrical current to the brain (tDCS) to see if it can safely reduce seizures in people with epilepsy that doesn't respond to medication. 127 participants aged 9 and older received either real or fake (sham) stimulation for 10 se…

This study tested whether foot reflexology massage could help people with epilepsy. 70 patients received reflexology sessions, and researchers measured changes in seizure frequency, fatigue, stress, and sleep quality. The goal was to see if this gentle foot massage could improve …

This study tested whether a structured education program could improve the quality of life for adults with epilepsy. 80 participants either received individual and group educational sessions or standard care. The goal was to see if learning more about the disease and its manageme…

This study tested whether mindfulness meditation training can improve quality of life and brain activity in people with refractory epilepsy (seizures that don't respond to drugs). 37 participants (patients and healthy volunteers) took part in meditation sessions. The main goal wa…

This study looked at whether a 12-week, at-home walking program using a step counter is practical for adults with epilepsy. Twenty-six participants used a Garmin watch to track steps and attended virtual sessions. The goal was to see if people could stick with their step targets …

This small pilot study tested whether intermittent fasting (eating only during an 8-hour window each day) could reduce seizures in 22 adults with epilepsy that doesn't respond to medication. Some participants also took medium-chain triglycerides (MCTs), a type of fat. The goal wa…

This study tested whether virtual reality (VR) exposure therapy could reduce anxiety in people with epilepsy who worry about their seizures. Fourteen participants were split into two groups: one received VR therapy using 360-degree videos of social or public settings, and the oth…

This study tested whether a neck massage program, based on a caring model, could help people with epilepsy feel more confident managing their condition, reduce their symptoms, and lighten the burden on their caregivers. 96 adults with epilepsy and their caregivers took part. The …

This study tested whether using role-playing exercises to teach epilepsy care improves nursing students' communication skills, confidence, and knowledge compared to standard lectures. 135 third-year nursing students in China took part. The goal is to find more effective ways to p…

This study looked at brain activity in 37 children with epilepsy using two devices: EEG (which records electrical brain signals) and NIRS (which measures blood oxygen levels in the brain). The goal was to better understand what happens in the brain during seizures and between sei…

This study looked at 10 children aged 3 to 14 with absence epilepsy, a type of seizure that causes brief lapses in awareness. Researchers used two noninvasive tools—near-infrared spectroscopy (NIRS) and electroencephalography (EEG)—to record brain activity and blood flow changes …

This study uses a non-invasive light-based technique called near-infrared spectroscopy (NIRS) combined with EEG to measure blood flow changes in the brains of children aged 3 to 6 years during infantile epilepsy spasms. The goal is to better understand what happens in the brain b…

This study looked at how people with temporal lobe epilepsy (TLE) remember spatial information, like directions, compared to healthy volunteers. Researchers tested memory right after a navigation task and again six weeks later. They wanted to see if people with TLE forget spatial…

This completed Stanford study looked at whether video-recorded facial expressions and speech patterns can reflect a person's mood. Eleven adults with depression or epilepsy had electrodes temporarily placed in their brains to record brain activity. Researchers stimulated certain …

This study surveyed 151 adults who had epilepsy surgery at least two years ago to see how their quality of life and daily experiences changed. Researchers used several questionnaires to measure satisfaction, anxiety, depression, and personal changes. The goal is to understand the…

This study looked at how weak electric currents applied to the scalp can change brain activity in people with drug-resistant focal epilepsy. Researchers used special brain recordings to measure spikes and connections between brain regions during and right after stimulation. The g…

This study uses computer models to simulate brain activity in 20 epilepsy patients. The goal is to better interpret EEG and MEG signals to locate where seizures start. Researchers hope this will lead to a tool that helps surgeons remove the right brain tissue to stop seizures.

This study looked at 60 epilepsy patients who already had electrodes implanted in their brains. Researchers recorded brain activity at the same time using scalp sensors and the implants. The goal was to see how well non-invasive methods can detect the same brain signals as the im…

This study tested whether special microelectrodes can record 'fast ripples'—tiny brain signals that may help locate where seizures start. 54 adults with drug-resistant epilepsy who needed brain monitoring for surgery planning took part. The goal was to see if these electrodes cou…

This completed study surveyed 90 adults with epilepsy to explore the stigma, misconceptions, and barriers they face in education, employment, and social settings. Participants filled out questionnaires designed by the research team. The goal is to identify unmet needs and inform …

This study looked at how epilepsy affects the quality of life of 90 adults. Researchers used a standard questionnaire called QOLIE-31 during routine clinic visits. The goal was to understand which parts of daily life are most impacted by epilepsy. This was an observational study,…

This completed study looked at whether healthcare professionals in Saudi Arabia received and understood safety materials about the epilepsy drug Depakine (sodium valproate). Researchers surveyed 455 doctors, pharmacists, and gynecologists to measure their knowledge and behavior. …

This study looked at how electrical brain stimulation influences approach and avoidance behavior in 13 patients with deep brain stimulators for OCD, depression, or epilepsy. Participants played a computer task with their stimulator turned on and off. The goal was to understand br…

This study tested a new type of brain sensor that is cheaper and easier to use than current ones. Researchers compared it to standard sensors in 4 people with epilepsy to see if it could detect abnormal brain activity. The goal is to make advanced brain imaging more widely availa…

This study tested a computer system designed to help doctors more accurately diagnose and manage complex brain disorders like dementia, epilepsy, and sleep problems. Researchers collected health data from 635 people visiting specialty clinics, including healthy volunteers, to see…

This study tested a new version of NPT 2042 soft-gelatin capsules to see if it is absorbed better than the original version. Eight healthy adults took single doses of both formulations. The goal was to measure how the drug moves through the body, not to treat any disease.

This study tested different settings of vagus nerve stimulation (VNS) in 16 adults with epilepsy who were already scheduled for VNS device surgery. Researchers measured how stimulation affected heart rate and throat muscle contractions to find ways to reduce side effects. The goa…

This study used 30 epilepsy patients who already had electrodes implanted in their brains for surgery planning. Researchers applied a mild electrical stimulation called tDCS and measured exactly how the current spread. The goal was to improve computer models that predict where th…

This study tested a computer system called Nelli that uses video cameras and machine learning to automatically detect seizures. Researchers compared Nelli's detection to the standard method (video-EEG) in 33 epilepsy patients. The goal was to see how accurately the AI could spot …

This study followed 188 children who had seizures shortly after birth to see how they develop over time. Researchers measured thinking skills, behavior, and daily function. The goal is to understand which children are at higher risk for conditions like cerebral palsy or intellect…

This study looked for early signs of epilepsy in children with autism and tested whether a structured exercise program could influence those signs. Fifty children aged 10-15 with autism, epilepsy, or both took part. Researchers analyzed blood, sleep, brain activity, and thinking …

This completed study looked at 72 newborns who had seizures shortly after birth. Researchers measured inflammation markers in their blood and tracked whether they later developed epilepsy. The goal was to understand if inflammation plays a role in epilepsy risk after neonatal sei…

This study aims to create an algorithm that detects epileptic seizures by continuously analyzing the heart's electrical activity (ECG). Researchers will use data from 40 epilepsy patients who had seizures recorded during long-term video-EEG monitoring. The goal is to see how accu…

This completed study looked at whether the sedative ketamine can cause seizure-like brain activity in people without epilepsy. Researchers monitored 300 adults undergoing a routine stomach scope procedure using EEG brain scans. They compared ketamine to two other common sedatives…

This study tested whether a gentle electrical current applied to the scalp can improve working memory in 9 adults with epilepsy who already had brain electrodes implanted. The stimulation targeted frontal and parietal brain areas at different frequencies. Researchers measured cha…

This study aimed to create a database of heart rate and movement data from 13 adults with drug-resistant epilepsy. Participants wore a connected patch that recorded heart rate and motion, while also undergoing video-EEG monitoring to confirm when seizures occurred. The goal was t…

This completed study looked at 753 children with epilepsy to better understand how their bodies process antiepileptic drugs. Researchers measured drug levels in the blood and considered factors like age, weight, and other medications. The goal is to create models that help doctor…

This study tested four different ways to deliver anxiety and depression screening questionnaires to adults with epilepsy before their clinic visits. Researchers wanted to see which method led to the highest completion rates. The goal is to make mental health screening easier and …

This study tested a mobile app designed to educate parents and caregivers of children with epilepsy. The app provides information about the condition, tracks symptoms, and helps manage appointments. Researchers wanted to see if using the app for one month would increase parents' …

This first-in-human study tested a new soft neural probe in 5 adults already scheduled for brain surgery to remove a tumor or epileptic tissue. The probe was inserted into the part of the brain being removed to see if it could be placed safely and record electrical signals. Parti…

This study tested two versions of the seizure medication stiripentol (Diacomit®) in 24 healthy adults: a capsule and a liquid suspension. The goal was to see if the liquid form is absorbed by the body in a similar way to the capsule. If so, it could provide a more convenient opti…

This study looked at how the brain's temporal lobe processes speech in 48 people with epilepsy who were already undergoing brain monitoring for their condition. Participants listened to sounds with varying pitch and timing while their brain activity was recorded. The goal was to …

This study looked at whether the ADHD Rating Scale-IV can detect changes in attention problems in children with epilepsy. Researchers followed 173 children aged 6 to 15 who had both epilepsy and ADHD. They compared scores over 12 to 16 weeks in treated versus untreated children t…

This study involved 47 people with drug-resistant epilepsy and healthy volunteers. Researchers recorded brain activity simultaneously using implanted electrodes (intracranial EEG) and non-invasive scans (MEG or fMRI). The goal was to better identify seizure-causing brain areas an…