EPILEPSY

This study tested whether training community health workers to treat childhood epilepsy can help close the treatment gap in Africa, where many children go without care. Over 1,600 children in Nigeria participated, with health workers providing epilepsy medicines and monitoring. T…

This study compared two oral seizure medications, brivaracetam and levetiracetam, in 102 children aged 1 month to 14 years with newly diagnosed epilepsy. The goal was to see which drug better stopped seizures and caused fewer side effects. Children who had never taken long-term s…

This study followed 345 people with epilepsy who use the RNS System, a brain implant that detects and stops seizures. Over 5 years, researchers tracked safety and how well the device reduces disabling seizures in everyday life. The goal was to confirm the device works safely outs…

This study tested whether adding brivaracetam to existing epilepsy medications helps reduce partial seizures in adults aged 16 to 80. Over 400 participants took either the drug or a placebo for 12 weeks. The main goals were to check safety and see if seizure frequency dropped. Re…

This study looked at how well the drug levetiracetam works for controlling seizures in people aged 60 and older with epilepsy. Researchers tracked how many patients stayed seizure-free, how long they continued the medication, and how well they tolerated it. The goal was to see if…

This study tested a device called NaviFUS™ that uses focused ultrasound to calm overactive brain areas in people with drug-resistant epilepsy. Twelve adults whose seizures were not controlled by medication received the treatment. The goal was to see if the device is safe and can …

This study tested whether naloxone, a drug that reverses opioid overdoses, could help people with epilepsy breathe better after a severe seizure. About 485 adults with drug-resistant epilepsy were monitored in the hospital. Those who had a generalized tonic-clonic seizure receive…

This study tested the safety of brivaracetam, a seizure medicine, in 257 children with epilepsy when added to their current treatment. The goal was to see how many children had side effects over time. Results help doctors understand if this drug is safe for long-term use in kids.

This pilot study tested a non-invasive brain stimulation technique called tDCS in 17 people with drug-resistant epilepsy. The stimulation was personalized based on each patient's seizure zone, previously mapped with brain electrodes. Researchers measured changes in seizure freque…

This study tested a mobile health program to help children with epilepsy take their medication regularly. 268 children aged 2-12 with recent epilepsy diagnosis used pill bottles that track doses, plus received reminders and problem-solving support. The goal was to improve medicat…

This study looked at whether adding a low dose of lacosamide to levetiracetam works better than a high dose of levetiracetam alone for people with epilepsy who still had seizures on low-dose levetiracetam. 56 adults took part. The main goal was to see how many became seizure-free…

This study tested a system called Nelli that uses cameras and artificial intelligence to detect seizures in children aged 6 to 21. The system was compared to the standard method, video-EEG, which uses electrodes on the scalp. The goal was to see if Nelli could correctly identify …

This study tested whether a 12-week, at-home step-goal program is doable for people with epilepsy. Twenty-six adults with epilepsy used a Garmin watch to track steps and attended virtual sessions. The goal was to see if they could stick with the program and how it might affect th…

This study tested a wearable cap that shines near-infrared light on the brain (called tPBM) in 6 autistic children aged 4–12 who also had abnormal brain waves or epilepsy. The children wore the device twice a week for 10 weeks. Researchers looked for improvements in focus, speech…

This study tested a device that sends a very mild electrical current to the brain (tDCS) to see if it can safely reduce seizures in people with epilepsy that doesn't respond to medication. 127 people aged 9 and older with focal epilepsy took part. They received either real or fak…

This study tested a technique called thermocoagulation in 100 children with drug-resistant focal epilepsy. During a brain monitoring procedure, doctors applied heat to the seizure-starting area to create tiny lesions, aiming to reduce seizure frequency. The goal was to see if thi…

This study tested whether a neck massage program, based on a caring model, could help people with epilepsy feel more confident managing their condition, reduce symptoms, and lighten the load on their caregivers. Researchers divided 96 adults with epilepsy into two groups: one rec…

This study tested whether a single dose of Staccato Alprazolam (a fast-acting form of a common anxiety medicine) could reduce abnormal brain activity triggered by flashing lights in people with photosensitive epilepsy. Five adults took either the medicine or a placebo, and resear…

This study looked at whether foot reflexology massage could help people with epilepsy. Researchers measured changes in seizure frequency, fatigue, stress, and sleep quality. 70 adults with epilepsy took part, and the goal was to see if this gentle foot therapy could improve their…

This study looked at whether practicing mindfulness meditation can help people with epilepsy that doesn't get better with medication. 37 people took part, including those with epilepsy and healthy volunteers. The goal was to see if meditation improves quality of life and changes …

This small pilot study tested whether intermittent fasting (eating only during an 8-hour window each day) could lower seizure frequency in 22 adults with drug-resistant epilepsy. Some participants also took medium-chain triglycerides (MCTs), a type of fat. The goal was to see if …

This study tested whether adding coenzyme Q10 (a natural substance found in the body) to standard epilepsy medications could safely reduce seizures in adults whose epilepsy does not respond to drugs alone. Thirty-nine adults with drug-resistant epilepsy took either coenzyme Q10 o…

This study tested whether taking zinc by mouth every day is safe and doable for people with GNAO1-related disorders, a rare genetic condition causing movement problems, seizures, and developmental delays. Thirteen participants aged 6 months to 30 years took zinc for 6 months. Res…

This study tested whether virtual reality (VR) exposure therapy can help people with epilepsy who feel anxious about their seizures. Fourteen adults participated, using VR for 5 minutes twice a day over 10 days. Researchers measured anxiety, depression, and quality of life before…

This study looked at whether a special education program can improve the quality of life for adults with epilepsy. 80 people took part, learning skills to manage their condition better. The goal was to see if those who joined the program felt a meaningful improvement compared to …

This study looked at whether safety information about the epilepsy drug Depakine (sodium valproate) is reaching doctors and pharmacists in Saudi Arabia. Researchers surveyed 455 healthcare professionals to see if they read and understood the safety materials. No treatment was giv…

This study followed 72 newborns who had seizures shortly after birth to understand how inflammation might be linked to developing epilepsy later. Researchers measured seizure activity and checked which babies went on to have epilepsy. The goal was to gather information, not to te…

This study tested whether a computer model, called a 'virtual brain,' can help doctors interpret brain signals in people with epilepsy. Twenty patients with planned brain electrode monitoring took part. The goal was to see if simulations could improve the identification of seizur…

This study compared a new soft-gel capsule version of NPT 2042 to the original in 8 healthy adults. The goal was to measure how the drug is absorbed and processed by the body. The results will help guide future dosing for conditions like epilepsy and Alzheimer's disease.

This study looked at how epilepsy surgery affects the daily lives of people with drug-resistant epilepsy. Researchers surveyed 151 patients who had surgery at least two years ago to understand their satisfaction and quality of life. The goal was to see if patients' personal exper…

This study looked at how playing sounds during sleep affects brain activity and memory in children with Rolandic epilepsy. Researchers used brain scans and memory tests to understand which brain circuits are involved. The goal is to find new ways to treat childhood epilepsy. The …

This study looked at how epilepsy affects quality of life in 90 adults. Researchers used a special questionnaire called QOLIE-31 during regular doctor visits to measure things like energy, mood, and daily activities. The goal was to better understand what life is like for people …

This study tested whether special microelectrodes can record 'fast ripples'—tiny brain signals that may mark where seizures begin. 54 adults with drug-resistant epilepsy who needed brain monitoring for surgery planning took part. The goal was to see if these electrodes work well …

This study looked at how the brain's temporal lobe processes speech sounds in 48 people with epilepsy who already had brain electrodes placed for medical reasons. Participants listened to speech sounds while their brain activity was recorded. The goal was to understand how the br…

This study measured the electrical fields created by a non-invasive brain stimulation technique called tDCS in 30 adults with epilepsy who already had electrodes implanted in their brains for medical reasons. The goal was to collect real-world data to improve computer models that…

This study tested a new, more affordable type of brain activity sensor (optical pumping magnetometer) against the standard expensive sensor (SQUID) in 4 people with epilepsy. The goal was to see if the new sensor could detect abnormal brain signals just as well. If successful, th…

This study looked at how epilepsy drugs behave in 753 children from birth to age 18. Researchers built computer models to understand how factors like weight, age, and genetics affect drug levels. The goal was to help doctors give the right dose to each child, not to test a new tr…

This study tested two forms of the seizure medication stiripentol (capsule and liquid) in 24 healthy adults to see if the liquid version works the same way in the body. Participants took a single dose of each form, and researchers measured drug levels in the blood. The goal is to…

This completed study surveyed 90 adults with epilepsy to understand the stigma and misconceptions they face in education, work, and social settings. Participants filled out questionnaires about their daily challenges and perceptions. The goal was to identify unmet needs and guide…

This study tested a computer system called Nelli that uses video cameras and machine learning to automatically detect seizures. 33 people with suspected epilepsy were monitored in a hospital unit. The goal was to see if the AI could spot seizures as accurately as the standard bra…

This study looked at how deep brain stimulation (DBS) influences the way people approach or avoid difficult decisions. Researchers tested 13 adults with DBS implants for severe OCD or depression, plus epilepsy patients with temporary brain electrodes. Participants played a comput…

This study involved 13 adults with drug-resistant epilepsy to create a database for developing a seizure detection algorithm. Researchers used a wearable patch to record heart rate and movement, while patients also underwent video-EEG monitoring as the gold standard. The goal is …

This study tested a mobile app designed to educate parents and caregivers of children with epilepsy. The goal was to see if using the app for one month could improve parents' knowledge about epilepsy and reduce their anxiety about seizures. The study involved 72 caregivers of chi…

This study aimed to create an algorithm that can detect epileptic seizures by continuously analyzing the heart's electrical activity (ECG). Researchers studied 40 patients with epilepsy who were already undergoing long-term video-EEG monitoring. The goal was to see how well the a…

This study looked at how brain scans (fMRI and MEG) relate to electrical signals recorded directly from the brain (intracranial EEG) in people with epilepsy and healthy volunteers. The goal was to better identify the area causing seizures and map healthy brain networks to avoid d…

This study looked for early warning signs of epilepsy in 50 children with autism, with or without epilepsy. Researchers tested blood, sleep, and thinking skills, and had the children follow a 3-month exercise program. The goal was to see if exercise could reduce seizures and impr…

This study tested a new high-density EEG method to map brain areas responsible for movement, sensation, language, and emotion. It included 122 people with epilepsy, brain tumors, and healthy volunteers. The goal was to improve understanding of brain function and seizure activity …

This study tested a new computer system that uses artificial intelligence to help doctors better diagnose and treat complex brain disorders like dementia, epilepsy, and sleep problems. Researchers collected information from 635 people, including healthy volunteers, to see if the …

This study looked at whether the ADHD rating scale can measure changes in attention problems in children with epilepsy. Researchers followed 173 children aged 6 to 15 with both epilepsy and ADHD. The goal was to see if the scale is sensitive enough to use in future treatment stud…

This study followed 188 children who had seizures shortly after birth to see how they develop over time. Researchers measured thinking skills and daily living abilities to find risk factors for disabilities like cerebral palsy or intellectual disability. The goal is to better und…

This study looked at how different settings of vagus nerve stimulation (VNS) affect heart rate and throat muscles in 16 adults with epilepsy. During surgery to implant or replace a VNS device, researchers tested various stimulation levels to find the point where side effects like…

This study looked at whether ketamine, a common sedative, might raise the chance of seizure-like brain activity compared to two other sedatives (midazolam and propofol). Researchers monitored 300 adults without epilepsy who were getting sedation for a routine stomach scope proced…

This study looked at different ways to screen adults with epilepsy for anxiety and depression. Researchers compared four methods of delivering screening questionnaires to see which one patients were most likely to complete before their clinic visit. The goal was to find the most …