Could inflammation after newborn seizures predict epilepsy?

NCT ID NCT04259125

Completed Knowledge-focused Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at 72 newborns who had seizures shortly after birth. Researchers measured inflammation markers in their blood and tracked whether they later developed epilepsy. The goal was to understand if inflammation plays a role in epilepsy risk after neonatal seizures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could help identify which newborns are at higher risk for epilepsy after seizures, leading to earlier monitoring or intervention.
What could go wrong: This is an observational study, not a treatment trial. It cannot prove cause and effect, and the small size (72 participants) limits how broadly the findings can be applied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

epilepsy Inflammation inflammatory disease visual epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPILEPSY INFLAMMATORY RESPONSE NEONATAL SEIZURE SEIZURES

Contacts and locations

Locations

Boston Children's Hospital

Boston, Massachusetts, 02115, United States
UCSF Benioff Children's Hospital Oakland

Oakland, California, 94609, United States
University of California, San Francisco

San Francisco, California, 94158, United States
University of Michigan, Mott Children's Hospital

Ann Arbor, Michigan, 48103, United States

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