Brain device zaps seizures in Tough-to-Treat epilepsy

NCT ID NCT05147571

Completed Disease control Sponsor: NeuroPace Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a brain implant (RNS System) that delivers targeted electrical stimulation to the thalamus to reduce seizures in people aged 12 and older with drug-resistant idiopathic generalized epilepsy. The goal was to see if the device is safe and effective at cutting down generalized tonic-clonic seizures. Participants had failed at least two seizure medications before joining.

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Conditions

The condition(s) this trial relates to.

epilepsy epilepsy with generalized tonic-clonic seizures idiopathic generalized epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPILEPSY GENERALIZED TONIC CLONIC SEIZURE IDIOPATHIC GENERALIZED EPILEPSY

Contacts and locations

Locations

Baylor College of Medicine

Houston, Texas, 77030, United States
Indiana University Health

Indianapolis, Indiana, 46202, United States
Mary Hitchcock Memorial Hospital (Dartmouth)

Lebanon, New Hampshire, 03756, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic - Arizona

Phoenix, Arizona, 85054, United States
Mayo Clinic - Rochester

Rochester, Minnesota, 55902, United States
New York University Langone

New York, New York, 10016, United States
Nicklaus Children's Hospital

Miami, Florida, 33155, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Spectrum Health Butterworth Hospital

Grand Rapids, Michigan, 48503, United States
The University of Texas Health Science Center at Houston

Houston, Texas, 77030, United States
Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States
UPMC

Pittsburgh, Pennsylvania, 15213, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States
University of Colorado

Aurora, Colorado, 80045, United States
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Louisville

Louisville, Kentucky, 40202, United States
University of New Mexico

Albuquerque, New Mexico, 87131, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of South Florida

Tampa, Florida, 33606, United States
University of Utah Healthcare

Salt Lake City, Utah, 84132, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Washington University

St Louis, Missouri, 63110, United States

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