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Brain Wave-Guided nerve stimulation may tame Drug-Resistant epilepsy

NCT ID NCT04693221

Ongoing Disease control Sponsor: Assistance Publique Hopitaux De Marseille Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether fine-tuning a vagal nerve stimulator (VNS) using a brain wave measure called phase lag index (PLI) can better reduce seizures in people with epilepsy that doesn't respond to medication. About 140 participants who already have a VNS device will have their settings chosen either by the PLI method or randomly. The goal is to see if the PLI-guided settings lead to fewer seizures per month.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
vagal nerve stimulation (VNS) device
What this could lead to
If successful, this could provide a more effective way to set VNS devices, helping more patients with drug-resistant epilepsy have fewer seizures.
What could go wrong
This is a mid-stage study with 140 participants, and the approach is still experimental. It may not work better than standard settings, and individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPILEPSY

Contacts and locations

Locations

  • Clinical neurophysiology, CHU Dijon

    Dijon, France, 21079, France

  • Clinical neurophysiology, CHU Lille

    Lille, France, 59037, France

  • Department of clinical neurophysiology, Hôpital La Timone, APHM

    Marseille, France, 13885, France

  • Department of functional explorations of the nervous system, CHU

    Amiens, France, 80054, France

  • Epilepsy neurophysiopathology department, CHU Grenoble

    Grenoble, France, 38043, France

  • Epileptology Department, CHU Rennes

    Rennes, France, 35000, France

  • HCL Lyon

    Lyon, France, 69003, France

  • Hôpital St Joseph St Luc

    Lyon, FRA, 69007, France

  • Neurology Department, CHU Bordeaux

    Bordeaux, France, 33000, France

  • Neurology Department, CHU Strasbourg

    Strasbourg, France, 67098, France

  • Neurology and clinical neurophysiology, CHU Bretonneau

    Tours, France, 37044, France

  • Neuropediatrics department, CHU Angers

    Angers, France, 49933, France

  • Neurophysiological explorations, Hôpital Pierre Paul Riquet, Purpan

    Toulouse, France, 31059, France

  • Neurophysiology Department

    Paris, France, 75014, France

  • Neurophysiology Department, CHU Rouen

    Rouen, France, 76000, France

  • Neurosurgery Department, APHP

    Paris, France, 75013, France

  • Neurosurgery Department, CHRU Nancy

    Nancy, France, 54000, France

  • Neurosurgery Department, CHU Nantes

    Nantes, France, 44093, France

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