Could a simple amino acid ease GRIN disorder symptoms? new trial aims to find out.
NCT ID NCT07377032
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether L-serine, a natural amino acid taken as a supplement, can improve overall functioning in children and young adults (ages 2-30) with GRIN-related neurodevelopmental disorders caused by certain gene variants. Each participant will receive both L-serine and a placebo in alternating periods, and researchers will compare results to see if the supplement helps with behavior, cognition, motor skills, and seizures. The trial is currently recruiting 40 participants across multiple centers.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
L-serine (a dietary supplement, a naturally occurring amino acid)
What this could lead to
If it works, this could point toward a safe, accessible supplement to improve daily functioning and reduce symptoms in people with GRIN-related disorders.
What could go wrong
This is still an early-stage trial with only 40 participants, so results may not apply to everyone. The supplement may cause side effects or show no clear benefit over placebo.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for EPILEPSY are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Children's Memorial Health Institute
RECRUITINGWarsaw, Poland
Contact Email: •••••@•••••
-
Hospices Civils de Lyon
NOT_YET_RECRUITINGLyon, 69002, France
Contact Email: •••••@•••••
-
Meyer Children's Hospital
RECRUITINGFlorence, 50139, Italy
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••