Could a simple amino acid ease GRIN disorder symptoms? new trial aims to find out.

NCT ID NCT07377032

Recruiting now Disease control Sponsor: Meyer Children's Hospital IRCCS Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether L-serine, a natural amino acid taken as a supplement, can improve overall functioning in children and young adults (ages 2-30) with GRIN-related neurodevelopmental disorders caused by certain gene variants. Each participant will receive both L-serine and a placebo in alternating periods, and researchers will compare results to see if the supplement helps with behavior, cognition, motor skills, and seizures. The trial is currently recruiting 40 participants across multiple centers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: L-serine (a dietary supplement, a naturally occurring amino acid)
What this could lead to: If it works, this could point toward a safe, accessible supplement to improve daily functioning and reduce symptoms in people with GRIN-related disorders.
What could go wrong: This is still an early-stage trial with only 40 participants, so results may not apply to everyone. The supplement may cause side effects or show no clear benefit over placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for EPILEPSY are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

disease epilepsy GRIN-related complex neurodevelopmental disorder neurodevelopmental disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPILEPSY GRIN-RELATED DISORDERS GRIN1 GRIN2A GRIN2B GRIN2D NEURODEVELOPMENTAL DISORDER (DIAGNOSIS)

Could a simple amino acid ease GRIN disorder symptoms? new trial aims to find out.

Summary

What this could mean

Get notified about this study

Conditions

As listed by the trial registrant

Contacts and locations

Locations

More trials for these conditions