Could a simple supplement ease GRIN disorder symptoms? new trial aims to find out.

NCT ID NCT07377032

Recruiting now Symptom relief Sponsor: Meyer Children's Hospital IRCCS Source: ClinicalTrials.gov ↗

First seen Feb 01, 2026 · Last updated May 14, 2026 · Updated 16 times

Summary

This study tests whether L-serine, a dietary supplement, can improve overall functioning in 40 children and young adults (ages 2-30) with GRIN-related neurodevelopmental disorders caused by loss-of-function gene variants. Each participant will receive both L-serine and a placebo in alternating periods to compare effects. The goal is to see if L-serine reduces symptom severity, improves behavior, cognition, and motor skills, and is safe to take.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Children's Memorial Health Institute
RECRUITING

Warsaw, Poland

Contact Email: •••••@•••••
Hospices Civils de Lyon
NOT_YET_RECRUITING

Lyon, 69002, France

Contact Email: •••••@•••••
Meyer Children's Hospital
RECRUITING

Florence, 50139, Italy

Contact Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

EPILEPSY GRIN-RELATED DISORDERS GRIN-RELATED DISORDERS GRIN1 GRIN1 GRIN2A GRIN2A GRIN2B GRIN2D NEURODEVELOPMENTAL DISORDER (DIAGNOSIS) NEURODEVELOPMENTAL DISORDER (DIAGNOSIS)