Tiny brain signals may guide better seizure surgery

NCT ID NCT06105645

Recruiting now Knowledge-focused Sponsor: University Hospital, Toulouse Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looks at whether measuring a specific type of brain wave called 'fast-ripples' can help surgeons do a better job treating drug-resistant epilepsy. About 440 patients will have brain monitoring with special electrodes before surgery. Half will have fast-ripple information used to plan their surgery, and half will not. The goal is to see if the fast-ripple group has fewer seizures one year after the operation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: DIXI Medical Microdeep® Micro-Macro Depth electrodes
What this could lead to: If successful, this could show that using fast-ripple information helps surgeons better identify and remove the seizure-causing brain tissue, leading to more patients being seizure-free after surgery.
What could go wrong: This is an early exploratory study, not a randomized trial. The benefit of fast-ripples is not yet proven, and the results may not apply to all epilepsy patients. There are also standard surgical risks like infection or bleeding.

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Conditions

The condition(s) this trial relates to.

epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPILEPSY

Contacts and locations

Locations

APHP Hôpital Bicêtre
RECRUITING

Le Kremlin-Bicêtre, 94270, France
CHRU de Nancy
RECRUITING

Nancy, France
CHU Amiens Picardie
RECRUITING

Amiens, France
CHU de Lille
RECRUITING

Lille, France
CHU de Rennes
RECRUITING

Rennes, France
Fondation Adolphe de Rothschild
NOT_YET_RECRUITING

Paris, 75019, France
Hospices Civils de Lyon
RECRUITING

Lyon, France
Hôpitaux universitaires de Strasbourg
RECRUITING

Strasbourg, France
University Hospital of Toulouse
RECRUITING

Toulouse, 31059, France
University hospital of Bordeaux
RECRUITING

Bordeaux, 33076, France
University hospital of Grenoble Alpes
RECRUITING

La Tronche, 38700, France

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