New hope for Drug-Resistant epilepsy? phase 2 trial launches

NCT ID NCT05518578

Recruiting now Disease control Sponsor: Supernus Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new drug called SPN-817 in 60 adults whose epilepsy does not improve with standard treatments. The main goal is to see if the drug is safe and tolerable. Researchers will also track whether it reduces the number of motor seizures. Participants take the drug as an oral capsule and keep a seizure diary.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SPN-817 (extended-release huperzine A)
What this could lead to: If it works, this could provide a new option for people with epilepsy that doesn't respond to current treatments, potentially reducing seizure frequency.
What could go wrong: This is an early-phase trial with only 60 people, so results may not apply to everyone. The main goal is safety, not proof of effectiveness, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

epilepsy visual epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPILEPSY SEIZURES, EPILEPTIC

Contacts and locations

Locations

Box Hill Hospital
RECRUITING

Box Hill, Victoria, 3128, Australia
Green Leaf Clinical Trials, LLC
RECRUITING

Jacksonville, Florida, 32258, United States
Prince of Wales Hospital
RECRUITING

Randwick, New South Wales, 2031, Australia
Royal Brisbane and Women's Hospital
RECRUITING

Brisbane, Queensland, 4006, Australia
Royal Prince Alfred Hospital
COMPLETED

Sydney, New South Wales, 2050, Australia
The Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
The Austin Hospital
RECRUITING

Heidelberg, Victoria, 3084, Australia
The Royal Melbourne Hospital
RECRUITING

Parkville, Victoria, 3050, Australia
Visionary Investigators Network
RECRUITING

Miami, Florida, 33133, United States
Westmead Hospital
COMPLETED

Sydney, New South Wales, 2145, Australia

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