Breakthrough hope: drug may stop epilepsy before it starts in TSC infants

NCT ID NCT05104983

Recruiting now Prevention Sponsor: Darcy Krueger Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving the drug sirolimus early in life can prevent or delay seizures in infants with tuberous sclerosis complex (TSC). About 64 babies under 7 months old will receive either sirolimus or a placebo. Researchers will track when seizures first appear and monitor safety.

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Conditions

The condition(s) this trial relates to.

tuberous sclerosis tuberous sclerosis 1 epilepsy prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPILEPSY TUBEROUS SCLEROSIS COMPLEX

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••
Contact

Email: •••••@•••••

Locations

Boston Children's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Children's Hospital Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Cincinnati Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States

Contact Email: •••••@•••••
Lurie Children's Hospital of Chicago
RECRUITING

Chicago, Illinois, 60611, United States
Seattle Children's Hospital
RECRUITING

Seattle, Washington, 98105, United States
Stanford University
RECRUITING

Palo Alto, California, 94304, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States
University of California at Los Angeles
RECRUITING

Los Angeles, California, 90095, United States
University of North Carolina at Chapel Hill
ACTIVE_NOT_RECRUITING

Chapel Hill, North Carolina, 27510, United States
University of Texas HSC at Houston
RECRUITING

Houston, Texas, 77030, United States
Washington University -- St. Louis
RECRUITING

St Louis, Missouri, 63110, United States

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