Your unique 'Sync Signature' could be key to beating depression

NCT ID NCT06749392

Recruiting now Knowledge-focused Sponsor: University of Haifa Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how the natural rhythm of connection between a therapist and patient—called synchrony—might help treat depression. Researchers will track 78 adults with major depressive disorder over 16 weeks of supportive-expressive therapy. The goal is to see if each person has a unique synchrony pattern and whether adjusting therapy to match that pattern leads to better mood and fewer symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: supportive-expressive psychotherapy
What this could lead to: If successful, this could lead to more personalized psychotherapy approaches that tailor the therapist-patient connection to each individual's needs, potentially improving depression treatment outcomes.
What could go wrong: This is an early-stage observational study with only 78 participants, so results may not apply to everyone. The concept of 'synchrony signatures' is new and unproven, and the study may not find clear links to symptom improvement.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

University of Haifa
RECRUITING

Haifa, 3498838, Israel

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