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Depression breakthrough? zimbabwe trial combines therapy and pills

NCT ID NCT06384209

Recruiting now Disease control Sponsor: University of Bern Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study in Zimbabwe tests whether adding antidepressants (fluoxetine or sertraline) to a proven talk therapy program (Friendship Bench) works better than talk therapy alone for adults with moderate to severe depression. About 296 participants will be randomly assigned to one of the two groups. The goal is to see if the combination leads to greater improvement in depression scores and to understand how nurses can prescribe these medications in primary care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Fluoxetine (or Sertraline for breastfeeding women)
What this could lead to
If it works, this could provide a more effective, scalable treatment for depression in low-resource settings by combining talk therapy with medication.
What could go wrong
This is a relatively small trial (296 people) in one country, so results may not apply everywhere. Adding medication also brings risks like side effects and the need for ongoing management.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER SEVERE DEPRESSIVE EPISODE WITHOUT PSYCHOTIC SYMPTOMS

Contacts and locations

Locations

  • University of Zimbabwe

    RECRUITING

    Harare, Zimbabwe

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