Ketamine's brain impact under the microscope in depression study
NCT ID NCT05327699
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how a single dose of ketamine changes brain chemistry and decision-making in people with major depression. Researchers will measure brain glutamate levels and stress responses in 140 participants. The goal is to understand why ketamine helps some people with depression, not to test it as a new treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ketamine
What this could lead to
If successful, this study could reveal how ketamine changes brain chemistry to reduce depression symptoms, pointing toward better treatments.
What could go wrong
This is a very early, small study focused on understanding brain mechanisms, not testing a proven treatment. Results may not lead to new therapies.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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